Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Manickam Yogavel"'
Autor:
Siddhartha Mishra, Nipun Malhotra, Benoît Laleu, Soumyananda Chakraborti, Manickam Yogavel, Amit Sharma
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110049- (2024)
Summary: The prolyl-tRNA synthetase (PRS) is an essential enzyme for protein translation and a validated target against malaria parasite. We describe five ATP mimetics (L95, L96, L97, L35, and L36) against PRS, exhibiting enhanced thermal stabilities
Externí odkaz:
https://doaj.org/article/af630037dd0645c6b8cbafbe9a69bcdc
Autor:
Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra, Jyoti Chhibber-Goel, Valeria Bellini, Karl Harlos, Benoît Laleu, Mohamed-Ali Hakimi, Amit Sharma
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011124 (2023)
The prolyl-tRNA synthetase (PRS) is a validated drug target for febrifugine and its synthetic analog halofuginone (HFG) against multiple apicomplexan parasites including Plasmodium falciparum and Toxoplasma gondii. Here, a novel ATP-mimetic centered
Externí odkaz:
https://doaj.org/article/e8c18ac0c4d34cadb55ade27bc2b2c94
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Autor:
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al. provide the biochemical and structural basis of its mechanism using co-crystal structure of PvcFRS
Externí odkaz:
https://doaj.org/article/96b3e407ffe647c5b54ac432fe843d79
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Inorganic pyrophosphatases (PPase) participate in energy cycling and they are essential for growth and survival of organisms. Here we report extensive structural and functional characterization of soluble PPases from the human parasites Plas
Externí odkaz:
https://doaj.org/article/4628c75d182f4e7996d49b30de5f982a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from Plasmodium knowlesi (Pk) and Plasmodi
Externí odkaz:
https://doaj.org/article/a30d2b6f7e1149cabfbec8aa2b140f53
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005084 (2016)
Helminth parasites are an assemblage of two major phyla of nematodes (also known as roundworms) and platyhelminths (also called flatworms). These parasites are a major human health burden, and infections caused by helminths are considered under negle
Externí odkaz:
https://doaj.org/article/3c793b7282b5484696cf5feb6c8202ff
Autor:
Sameena Khan, Ankur Garg, Arvind Sharma, Noelia Camacho, Daria Picchioni, Adélaïde Saint-Léger, Lluís Ribas de Pouplana, Manickam Yogavel, Amit Sharma
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66224 (2013)
Specific activation of amino acids by aminoacyl-tRNA synthetases (aaRSs) is essential for maintaining fidelity during protein translation. Here, we present crystal structure of malaria parasite Plasmodium falciparum tryptophanyl-tRNA synthetase (Pf-W
Externí odkaz:
https://doaj.org/article/a86cd5e76c5c484da3af81fee0fa99f5
Autor:
Manickam, Yogavel, Chaturvedi, Rini, Babbar, Palak, Malhotra, Nipun, Jain, Vitul, Sharma, Amit
Publikováno v:
In Drug Discovery Today June 2018 23(6):1233-1240
Autor:
Manickam, Yogavel1 (AUTHOR), Malhotra, Nipun1 (AUTHOR), Mishra, Siddhartha1,2,3 (AUTHOR), Babbar, Palak1 (AUTHOR), Dusane, Abhishek1 (AUTHOR), Laleu, Benoît4 (AUTHOR), Bellini, Valeria5 (AUTHOR), Hakimi, Mohamed-Ali5 (AUTHOR), Bougdour, Alexandre5 (AUTHOR) alexandre.bougdour@univ-grenoble-alpes.fr, Sharma, Amit1,2,3 (AUTHOR) alexandre.bougdour@univ-grenoble-alpes.fr
Publikováno v:
PLoS Pathogens. 3/25/2022, Vol. 18 Issue 3, p1-17. 17p.
Publikováno v:
Protein Sci
Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and P. vivax (Pv) are responsible for causing malaria in humans. According
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96135033800aed2172e728d8124a1da
https://doi.org/10.1002/pro.4148
https://doi.org/10.1002/pro.4148