Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Manickam Janakiraman"'
Autor:
James A. Fagin, Ronald A. Ghossein, R. Michael Tuttle, Jeffrey A. Knauf, David Solit, Manickam Janakiraman, Marc Ladanyi, Adriana Heguy, Michael Rivera, Dhananjay A. Chitale, Mabel Ryder, Julio C. Ricarte-Filho
Supplementary Figure 1 from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7951b7ab8258bdc2240deceac6218f
https://doi.org/10.1158/0008-5472.22377221
https://doi.org/10.1158/0008-5472.22377221
Autor:
David B. Solit, Philip B. Paty, Adriana Heguy, Leonard B. Saltz, Marc Ladanyi, Alex Lash, John M. Mariadason, Suresh C. Jhanwar, James A. Fagin, Douglas A. Levine, Yogindra Persaud, Julio Cezar Ricarte Filho, Kety Huberman, Manda Wilson, Ensar Halilovic, Dhananjay Chitale, Barry S. Taylor, Christine A. Pratilas, Zhaoshi Zeng, Efsevia Vakiani, Manickam Janakiraman
Supplementary Figures 1-3, Tables 1-9, Methods from Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62ed49f3f3781aad5e9033366ee6c4f
https://doi.org/10.1158/0008-5472.22383576.v1
https://doi.org/10.1158/0008-5472.22383576.v1
Autor:
James A. Fagin, Ronald A. Ghossein, R. Michael Tuttle, Jeffrey A. Knauf, David Solit, Manickam Janakiraman, Marc Ladanyi, Adriana Heguy, Michael Rivera, Dhananjay A. Chitale, Mabel Ryder, Julio C. Ricarte-Filho
Supplementary Figure Legend, Tables 1-3 from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bf501a703418d46952b7311aaba88c
https://doi.org/10.1158/0008-5472.22377218
https://doi.org/10.1158/0008-5472.22377218
Autor:
James A. Fagin, Ronald A. Ghossein, R. Michael Tuttle, Jeffrey A. Knauf, David Solit, Manickam Janakiraman, Marc Ladanyi, Adriana Heguy, Michael Rivera, Dhananjay A. Chitale, Mabel Ryder, Julio C. Ricarte-Filho
Supplementary Table 4 from Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c27e7216c2539a3013a7c9218693b5b
https://doi.org/10.1158/0008-5472.22377215.v1
https://doi.org/10.1158/0008-5472.22377215.v1
Autor:
David B. Solit, Neal Rosen, Adi Gazdar, Marc Ladanyi, Shinichi Toyooka, William Pao, Barry S. Taylor, Manickam Janakiraman, Ayana Sawai, Hiromasa Yamamoto, Hisayuki Shigematsu, Dhananjay Chitale, Junichi Soh, Yogindra Persaud, Ensar Halilovic, Aphrothiti J. Hanrahan, Christine A. Pratilas
Supplementary Materials from Genetic Predictors of MEK Dependence in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d48bead40b73c2410daffc0d6f0af94
https://doi.org/10.1158/0008-5472.22375757
https://doi.org/10.1158/0008-5472.22375757
Autor:
David B. Solit, Philip B. Paty, Adriana Heguy, Leonard B. Saltz, Marc Ladanyi, Alex Lash, John M. Mariadason, Suresh C. Jhanwar, James A. Fagin, Douglas A. Levine, Yogindra Persaud, Julio Cezar Ricarte Filho, Kety Huberman, Manda Wilson, Ensar Halilovic, Dhananjay Chitale, Barry S. Taylor, Christine A. Pratilas, Zhaoshi Zeng, Efsevia Vakiani, Manickam Janakiraman
Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor (EGFR)–targeted therapies, limited clinical testing for RAS pathway muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4155bfa59f0aaa6b4ba6253d78cf53a
https://doi.org/10.1158/0008-5472.c.6500589
https://doi.org/10.1158/0008-5472.c.6500589
Autor:
Salvatore Siena, Margherita Gallicchio, Silvio Veronese, Roberta Schiavo, Efsevia Vakiani, Federica Di Nicolantonio, Giulia Siravegna, Andrea Cercek, Rona Yaeger, Valentina Boscaro, Alberto Bardelli, Chin Tung Chen, Enzo Medico, Emanuele Valtorta, Manickam Janakiraman, David B. Solit, Elisa Scala, Sandra Misale, Marcello Gambacorta, Michela Buscarino, Carlo Zanon, David Liska, Katia Bencardino, Sebastijan Hobor, Martin R. Weiser, Andrea Sartore-Bianchi
Publikováno v:
Nature; Vol
ResearcherID
ResearcherID
A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effec
Autor:
Arjun Vasant Balar, Jamie Riches, Manickam Janakiraman, David B. Solit, Matthew I. Milowsky, Samson W. Fine, Ying-Bei Chen, Victor E. Reuter, Guido Dalbagni, Anuradha Gopalan, Dean F. Bajorin, Oscar Lin, Bernard H. Bochner, Adriana Heguy, Satish K. Tickoo, Hikmat Al-Ahmadie, Gopa Iyer
Publikováno v:
The Journal of Pathology. 224:270-279
FGFR3 mutations are common in low-grade urothelial carcinoma and represent a potential therapeutic target in this disease. Their incidence and functional role in high-grade urothelial carcinoma (HGUC), which displays an increased propensity for recur
Autor:
Manickam Janakiraman, Michael Rivera, David B. Solit, Dhananjay Chitale, Julio C. Ricarte-Filho, Adriana Heguy, R. Michael Tuttle, Jeffrey A. Knauf, James A. Fagin, Marc Ladanyi, Ronald Ghossein, Mabel Ryder
Publikováno v:
Cancer Research. 69:4885-4893
Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC), and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality, particularly if positive on [18F]fluorodeoxyglucose (FDG)-pos
Autor:
Werner Emberger, Claudia Bodner, Armin Zebisch, Ali Delavar, Michael G. Schimek, Karin Hiden, Heinz Sill, Manickam Janakiraman, Philipp B. Staber, Christian Windpassinger, Jakob Troppmair, Holger W. Auner, Katja Fischereder, Werner Linkesch, Gerald Hoefler
Publikováno v:
Cancer Research. 66:3401-3408
Mutations leading to activation of the RAF-mitogen-activated protein kinase/extracellular signal-regulated (ERK) kinase (MEK)-ERK pathway are key events in the pathogenesis of human malignancies. In a screen of 82 acute myeloid leukemia (AML) samples