Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Manickam Aravagiri"'
Publikováno v:
Journal of Chromatography B. 847:237-244
An accurate, rapid and simple liquid chromatography–tandem mass spectrometry (LC–MS–MS) assay method was developed for the determination of ziprasidone (ZIP) in the plasma of schizophrenia patients. A simple one step liquid–liquid extraction
Autor:
Lawrence J. Albers, Christopher Reist, Stephen R. Marder, Laszlo Endrenyi, Maria Augusta Raggi, Vural Özdemir, Manickam Aravagiri
Publikováno v:
Journal of Clinical Psychopharmacology. 25:170-174
Despite the advances in antipsychotic pharmacotherapy over the past decade, many atypical antipsychotic agents are not readily accessible by patients with major psychosis or in developing countries where the acquisition costs may be prohibitive. Olan
Autor:
Stephen R. Marder, Manickam Aravagiri
Publikováno v:
Psychopharmacology. 159:424-431
Rationale: Following an oral dose of risperidone (RSP), concentrations of its major metabolite 9-hydroxyrisperidone (9-OHRSP) were high in plasma and tissues but disproportionately lower in the brain compared to RSP, indicating that 9-OHRSP may have
Autor:
David L. Fogelson, Jim Mintz, Michael J. Gitlin, Keith H. Nuechterlein, George Bartzokis, Joseph Ventura, Manickam Aravagiri, Kenneth L. Subotnik
Publikováno v:
American Journal of Psychiatry. 158:1835-1842
Objective: The goal of this report was to examine the clinical course following neuroleptic discontinuation of patients with recent-onset schizophrenia who had been receiving maintenance antipsychotic treatment for at least 1 year. Method: Fifty-thre
Autor:
Manickam Aravagiri, Stephen R. Marder
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 26:301-311
A liquid chromatography tandem mass spectrometry (LC-MS-MS) assay method for the simultaneous determination of clozapine and its N-desmethyl (norclozapine) and N-oxide metabolites in human plasma is described. The compounds were extracted from plasma
Autor:
David L. Fogelson, George Bartzokis, Jim Mintz, Manickam Aravagiri, Keith H. Nuechterlein, Kenneth L. Subotnik, Joseph Ventura, Michael J. Gitlin
Publikováno v:
Psychopharmacology. 148:350-354
Rationale: The utility of fluphenazine levels during maintenance treatment of schizophrenia is still unclear. Objectives: This study investigated the relationship between fluphenazine levels and a variety of clinical measures during maintenance treat
Autor:
Stephen R. Marder, Manickam Aravagiri
Publikováno v:
Journal of Mass Spectrometry. 35:718-724
A simple and highly sensitive liquid chromatographic/electrospray tandem mass spectrometric (LC/MS/MS) assay was developed for the simultaneous determination of risperidone (RSP) and its major circulating metabolite 9-hydroxyrisperidone (9-OH-RSP) in
Publikováno v:
Biopharmaceutics & Drug Disposition. 20:369-377
The single dose pharmacokinetics of olanzapine in rats, following an oral dose and its distribution in the brain and other tissues after repeated oral and intra-peritoneal (i.p.) administration, were studied. Olanzapine in plasma, brain, liver, lung,
Publikováno v:
Psychopharmacology. 139:356-363
Rats were treated with daily oral doses of 1, 4, and 6 mg/kg risperidone (RSP) and its metabolite, 9-hydroxy-risperidone (9-OH-RSP), for 15 consecutive days. Concentrations of RSP and 9-OH-RSP were measured in plasma, brain, liver, kidney, lungs and
Autor:
Kamal K. Midha, Edward M. Hawes, Gordon McKay, Manickam Aravagiri, Stephen R. Marder, T. Van Putten
Publikováno v:
Therapeutic Drug Monitoring. 16:21-29
Immunization of New Zealand white rabbits with a bovine serum albumin conjugate of 7-hydroxy-N-carboxyethyl-N-deshydroxyethylfluphenazine produced highly specific antisera for 7-hydroxyfluphenazine (7-OHFLU). A radioimmunoassay (RIA) was developed us