Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Mani, Larijani"'
Autor:
Atefeh Ghorbani, S. Javad Khataeipour, Monica H. Solbakken, David N. G. Huebert, Minasadat Khoddami, Khalil Eslamloo, Cassandra Collins, Tiago Hori, Sissel Jentoft, Matthew L. Rise, Mani Larijani
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-32 (2022)
Abstract Background Antibody affinity maturation in vertebrates requires the enzyme activation-induced cytidine deaminase (AID) which initiates secondary antibody diversification by mutating the immunoglobulin loci. AID-driven antibody diversificatio
Externí odkaz:
https://doaj.org/article/e0239cf7435d4e5a80ab9bdf7580c822
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The immune system is unique among all biological sub-systems in its usage of DNA-editing enzymes to introduce targeted gene mutations and double-strand DNA breaks to diversify antigen receptor genes and combat viral infections. These processes, initi
Externí odkaz:
https://doaj.org/article/65f9e83758e14fe7908dffbcf893e985
Autor:
Stephen P. Methot, Ludivine C. Litzler, Poorani Ganesh Subramani, Anil K. Eranki, Heather Fifield, Anne-Marie Patenaude, Julian C. Gilmore, Gabriel E. Santiago, Halil Bagci, Jean-François Côté, Mani Larijani, Ramiro E. Verdun, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcri
Externí odkaz:
https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
Autor:
Michael Grant, Mani Larijani
Publikováno v:
AIDS Research and Therapy, Vol 14, Iss 1, Pp 1-4 (2017)
Abstract APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In v
Externí odkaz:
https://doaj.org/article/48f11283c346470a8defc17585d2c6c4
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Viperin is a key antiviral effector in immune responses of vertebrates including the Atlantic cod (Gadus morhua). Using cloning, sequencing and gene expression analyses, we characterized the Atlantic cod viperin at the nucleotide and hypothetical ami
Externí odkaz:
https://doaj.org/article/6bb27eb571924b4cbca9111b3fa639e6
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
APOBEC3G (A3G) is a host enzyme that mutates the genomes of retroviruses like HIV. Since A3G is expressed pre-infection, it has classically been considered an agent of innate immunity. We and others previously showed that the impact of A3G-induced mu
Externí odkaz:
https://doaj.org/article/a62c3e9fce5144838e1eb28e3d4d3bb0
Publikováno v:
Biochemical Journal. 479:39-55
Activation-induced cytidine deaminase (AID) is a member of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of cytidine deaminases. AID mutates immunoglobulin loci to initiate secondary antibody diversification. Th
Autor:
Sarah Grasedieck, Afsaneh Panahi, Matthew C. Jarvis, Faezeh Borzooee, Reuben S. Harris, Mani Larijani, Hervé Avet-Loiseau, Mehmet Samur, Nikhil Munshi, Kevin Song, Arefeh Rouhi, Florian Kuchenbauer
Background: Recent insights into the pathogenesis of multiple myeloma (MM) have highlighted inflammation and genome editing, e.g. by APOBEC enzymes, as major drivers of disease onset and progression. We hypothesized that inclusion of molecular featur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37948463e8a67b7dbb561ff5cd4d1ab
https://doi.org/10.21203/rs.3.rs-2184702/v1
https://doi.org/10.21203/rs.3.rs-2184702/v1
Autor:
Mani Larijani, Justin J. King
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Activation-induced cytidine deaminase (AID) and its relative APOBEC3 cytidine deaminases boost immune response by mutating immune or viral genes. Because of their genome-mutating activities, AID/APOBECs are also drivers of tumorigenesis. Due to highl
Externí odkaz:
https://doaj.org/article/4e15ce18c3f042c5ae37a627ccef5533
Autor:
Afsaneh Panahi, Sarah Grasedieck, Matthew Jarvis, Faezeh Borzooee, Reuben Harris, Mani Larijani, Kevin Song, Arefeh Rouhi, Florian Kuchenbauer
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S117-S118