Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mangzhu Zhao"'
Autor:
Song Qiuling, Wenxue Wu, Jie Yan, Shinya Iimura, Mark S. Bednarz, Dai Kuangchu, Matthew Mangzhu Zhao, Haiming Zhang, Xiaodong Gu, Youchu Wang, Ngiap-Kie Lim
Publikováno v:
Organic Process Research & Development. 24:2689-2701
The development of an efficient manufacturing process for sotagliflozin (LX4211), a dual inhibitor of sodium–glucose cotransporter-1/2 (SGLT-1/2) for the treatment of diabetes, is described. Sotagl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3755ff6820ddf3fa9552ad3ec4a108
https://doi.org/10.1021/acs.oprd.0c00359
https://doi.org/10.1021/acs.oprd.0c00359
Autor:
Wenxue Wu, Lauren E. Sirois, Bryce Alden Harrison, Ngiap-Kie Lim, Matthew Mangzhu Zhao, Mark S. Bednarz
Publikováno v:
Organic Process Research & Development. 23:45-61
Process development for the synthesis of a locally acting sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, LX2761, a drug candidate for the treatment of diabetes mellitus, is described. ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd6520429d94d058e46a42dac21dd4e6
https://doi.org/10.1021/acs.oprd.8b00325
https://doi.org/10.1021/acs.oprd.8b00325
Autor:
Robert A. Reamer, Edward J. J. Grabowski, Todd D. Nelson, Andrew S. Thompson, Mangzhu Zhao, Paul J. Reider, Martha Huntington, Anthony M. Demarco, Zhiguo Jake Song
Publikováno v:
Tetrahedron Letters. 41:1877-1881
A catalyst system of Rh2(oct)4/DIPEA or TMU allows for the rapid construction of α-alkoxyketones from the corresponding α-diazo ketone and alcohol. This methodology was applied to the synthesis of immunoregulant 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cab98760c8f367b15be17d0ad111196a
https://doi.org/10.1016/s0040-4039(00)00069-1
https://doi.org/10.1016/s0040-4039(00)00069-1
Autor:
Paul N. Devine, Bruce S. Foster, Shigemitsu Okada, Richard M. Heid, Edward J. J. Grabowski, Zhiguo J. Song, Eiichi Mano, Ralph P. Volante, David M. Tschaen, Mangzhu Zhao, Ulf H. Dolling, Richard Desmond, Yoshiaki Kato, Jing Li, Paul J. Reider, Lisa F. Frey, Richard D. Tillyer, Robert A. Reamer, Feng Xu
Publikováno v:
The Journal of Organic Chemistry. 64:9658-9667
An efficient, practical, asymmetric synthesis of the endothelin receptor antagonist 1 is reported. The key pyridine-fused cyclopentane ring bearing three consecutive chiral centers was constructed ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ade13fe92f3c724b52b40d387f8173
https://doi.org/10.1021/jo991292t
https://doi.org/10.1021/jo991292t
Autor:
Robert A. Reamer, Martha Huntington, Edward G. Corley, Fuh-Rong Tsay, Dale L. Rieger, James M. McNamara, Paul J. Reider, Andrew S. Thompson, Yulan Li, Anthony M. Demarco, Edward J. J. Grabowski, David M. Tschaen, Guo Jie Ho, Zhiguo Song, Richard F. Shuman, Paul Sohar, Mangzhu Zhao, David J. Mathre, Khateeta M. Emerson
Publikováno v:
The Journal of Organic Chemistry. 64:1859-1867
L-733,725, a new immunosuppressant drug candidate, was prepared by a highly chemoselective alkylation of the macrolide ascomycin at the C32 hydroxy position with the imidazolyl trichloroacetimidate 16. The trichloroacetimidate-activated side chain 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab561a56d64462267c0491abb0f62f4d
https://doi.org/10.1021/jo981805g
https://doi.org/10.1021/jo981805g
Autor:
Yoshiaki Kato, Mangzhu Zhao, Richard M. Heid, Paul N. Devine, Eiichi Mano, Richard D. Tillyer, Shigemitsu Okada, Zhiguo Song, Richard Desmond, Shinji Kato, Lisa F. Frey, David M. Tschaen, Toshiaki Mase
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 57:1016-1025
Two distinct synthetic approaches to the biologically active and structurally unique endothelin antagonist J-104132 (1) have been developed Each synthesis involves a highly selective intramolecular cyclization of a late stage intermediate (bottom to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817061fe8709fd705be7619b7ac89313
https://doi.org/10.5059/yukigoseikyokaishi.57.1016
https://doi.org/10.5059/yukigoseikyokaishi.57.1016
Autor:
Paul J. Reider, Mangzhu Zhao, D. M. Tschaen, Edward J. J. Grabowski, Richard Desmond, Zhiguo Song, Jing Li
Publikováno v:
Tetrahedron Letters. 39:5323-5326
A novel CrO 3 catalyzed oxidation of primary alcohols to the carboxylic acids is reported. The oxidation proceeds smoothly with only 1–2 mol % of CrO 3 and 2.5 equivalents of H 5 IO 6 in wet MeCN to give the carboxylic acids in excellent yield. No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab79c5cd6b482960de09135223700910
https://doi.org/10.1016/s0040-4039(98)00987-3
https://doi.org/10.1016/s0040-4039(98)00987-3
Autor:
Mangzhu Zhao, Leo A. Paquette
Publikováno v:
Journal of the American Chemical Society. 120:5203-5212
In a study directed toward the expeditious construction of heavily functionalized taxane intermediates, 1-vinyl-2-cyclohexenyl-7,7-dimethyl-exo-norbornan-2-ols such as 9, which are derived from D-camphor are shown to undergo stereocontrolled oxyanion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca3082dcc680f2ab7ee333fdce745634
https://doi.org/10.1021/ja9805371
https://doi.org/10.1021/ja9805371
Publikováno v:
Journal of the American Chemical Society. 120:5213-5225
A total synthesis of (+)-taxusin (1) has been realized by virtue of the development of a practical route for complete functionalization of the A ring. To achieve this goal, it proved necessary to devise a strategy that would enable chemical transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befbe63ef58fac19c3ebfb655080ffc3
https://doi.org/10.1021/ja980538t
https://doi.org/10.1021/ja980538t
Publikováno v:
Tetrahedron Letters. 38:2641-2644
A convenient and economical in situ preparation of DIP-Chloride tm from NaBH4, BCl3 and α-pinene is described. Its application in the asymmetric reduction of representative aralkyl ketones is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6c7e9c07e91c46d279c54fecc1db32e
https://doi.org/10.1016/s0040-4039(97)00440-1
https://doi.org/10.1016/s0040-4039(97)00440-1