Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mangubat-Medina A"'
Autor:
Stevens, Alexandra M., Xiang, Michael *, Heppler, Lisa N., Tošić, Isidora, Jiang, Kevin, Munoz, Jaime O., Gaikwad, Amos S., Horton, Terzah M., Long, Xin, Narayanan, Padmini, Seashore, Elizabeth L., Terrell, Maci C., Rashid, Raushan, Krueger, Michael J., Mangubat-Medina, Alicia E., Ball, Zachary T., Sumazin, Pavel, Walker, Sarah R., Hamada, Yoshimasa, Oyadomari, Seiichi, Redell, Michele S., Frank, David A.
Publikováno v:
In Blood Advances 23 December 2019 3(24):4215-4227
Autor:
Alexandra M. Stevens, Michael Xiang, Lisa N. Heppler, Isidora Tošić, Kevin Jiang, Jaime O. Munoz, Amos S. Gaikwad, Terzah M. Horton, Xin Long, Padmini Narayanan, Elizabeth L. Seashore, Maci C. Terrell, Raushan Rashid, Michael J. Krueger, Alicia E. Mangubat-Medina, Zachary T. Ball, Pavel Sumazin, Sarah R. Walker, Yoshimasa Hamada, Seiichi Oyadomari, Michele S. Redell, David A. Frank
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4215-4227 (2019)
Abstract: Atovaquone, a US Food and Drug Administration–approved antiparasitic drug previously shown to reduce interleukin-6/STAT3 signaling in myeloma cells, is well tolerated, and plasma concentrations of 40 to 80 µM have been achieved with pedi
Externí odkaz:
https://doaj.org/article/4187c59f20f14fd4af323bb29b1514a1
Akademický článek
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Publikováno v:
Chemical Society Reviews. 50:10403-10421
There has been a significant push in recent years to deploy fundamental knowledge and methods of photochemistry toward biological ends. Photoreactive groups have enabled chemists to activate biological function using the concept of photocaging. By gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7878abc9f52001dc83d000709a56064
https://doi.org/10.1039/d0cs01434f
https://doi.org/10.1039/d0cs01434f
Autor:
Taysir K. Bader, Zachary T. Ball, Hallie O. Trial, Mark D. Distefano, Mekedlawit T. Setegne, Reyner D. Vargas, Alicia E. Mangubat-Medina
Publikováno v:
Organic & Biomolecular Chemistry. 18:5110-5114
Light is a uniquely powerful tool for spatiotemporal control of molecular structure, necessitating the development of new photocaging approaches. This communication describes the design, synthesis, and reactivity of two new photoreactive boronic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a822466d6771e4a96c1c11c4d2868d2e
https://doi.org/10.1039/d0ob00923g
https://doi.org/10.1039/d0ob00923g
Autor:
Wei Liu, Jaime O. Munoz, Zachary T. Ball, Michael J. Krueger, Mikhail Kolosov, Julian C. Cooper, Michele S. Redell, Alicia E. Mangubat-Medina, Haopei Wang, Moses M. Kasembeli, Matthew B. Minus, David J. Tweardy, Alexandra M. Stevens
Publikováno v:
Org Biomol Chem
Recurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents. STAT3 has emerged as a potential target in resistant AML, but inhibiting STAT3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa77329ce1d82f3d84bee62dc672b9b
https://doi.org/10.1039/c9ob02682g
https://doi.org/10.1039/c9ob02682g
Akademický článek
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Akademický článek
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Publikováno v:
Journal of the American Chemical Society. 140:8401-8404
Side-chain modifications that respond to external stimuli provide a convenient approach to control macromolecular structure and function. Responsive modification of backbone amide structure represents a direct and powerful alternative to impact foldi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e884dd25b93bafde7dbf02362b1e2599
https://doi.org/10.1021/jacs.8b04893
https://doi.org/10.1021/jacs.8b04893
Autor:
Eunji Jo, Alicia E. Mangubat-Medina, Allison Weisnicht, Cara A Rabik, Susan G. Hilsenbeck, Todd M. Cooper, Hana Paek, Michelle C Alozie, Alexandra M. Stevens, Zachary T. Ball, Michele S. Redell, Minhua Li, Hailey H Oviedo, Alan K Gonzalez, Claire E. Bocchini, Haopei Wang, Maci Terrell, Raushan Rashid, Noah J Keogh, Eric S. Schafer
Publikováno v:
Blood. 138:2312-2312
Background Relapse free survival of pediatric AML remains only 60%. Current standard myelosuppressive therapy has been maximized, so novel therapies with minimal toxicities are needed to improve outcomes. Previously, we found atovaquone (AQ), an FDA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0334ccefb5db8ce34b0c410aadef4e6
https://doi.org/10.1182/blood-2021-146057
https://doi.org/10.1182/blood-2021-146057