Clostridium sporogenes-derived metabolites protect mice against colonic inflammation

Autor: Krause, Felix F., Mangold, Kira I., Ruppert, Anna-Lena, Leister, Hanna, Hellhund-Zingel, Anne, Lopez Krol, Aleksandra, Pesek, Jelena, Watzer, Bernhard, Winterberg, Sarah, Raifer, Hartmann, Binder, Kai, Kinscherf, Ralf, Walker, Alesia, Nockher, Wolfgang A., Taudte, R. Verena, Bertrams, Wilhelm, Schmeck, Bernd, Kühl, Anja A., Siegmund, Britta, Romero, Rossana, Luu, Maik, Göttig, Stephan, Bekeredjian-Ding, Isabelle, Steinhoff, Ulrich, Schütz, Burkhard, Visekruna, Alexander

Publikováno v: Gut Microbes; December 2024, Vol. 16 Issue: 1

Microbial metabolite-guided CAR T cell engineering enhances anti-tumor immunity via epigenetic-metabolic crosstalk.

Autor: Staudt S; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Nikolka F; Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany., Perl M; University Hospital Regensburg, Department of Internal Medicine III, Hematology & Internal Oncology, Regensburg, Germany., Franz J; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Leblay N; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Yuan XK; Precision Oncology Hub, Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Warmuth L; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany., Fantes MA; University Hospital Regensburg, Department of Internal Medicine III, Hematology & Internal Oncology, Regensburg, Germany., Skorupskaitė A; Life Sciences Center - European Molecular Biology Laboratory (LSC-EMBL) Partnership for Genome Editing Technologies, Vilnius University - Life Sciences Center, Vilnius University, Vilnius, Lithuania., Fei T; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Bromberg M; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Martin-Uriz PS; Hemato-Oncology Program, Cima Universidad de Navarra, Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Cancer Center Clinica Universidad de Navarra (CCUN), IdiSNA, Pamplona, Spain., Rodriguez-Madoz JR; Hemato-Oncology Program, Cima Universidad de Navarra, Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Cancer Center Clinica Universidad de Navarra (CCUN), IdiSNA, Pamplona, Spain., Ziegler-Martin K; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Gholam NA; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Benz P; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Tran PH; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Vienna, Austria., Freitag F; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Riester Z; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.; Mildred Scheel Early Career Center, University Hospital of Würzburg, Würzburg, Germany., Stein-Thoeringer C; Innere Medizin I, Universitätsklinikum Tübingen & M3 Research Center, Universitätsklinikum Tübingen., Schmitt M; Department of Hematology, Oncology and Rheumatology, University Clinic Heidelberg, Heidelberg, Germany., Kleigrewe K; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, Freising, Germany., Weber J; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Mangold K; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.; Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany., Einsele H; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Prosper F; Hematology and Cell Therapy Department, Clinica Universidad de Navarra (CUN), Hemato-Oncology Program, Cima Universidad de Navarra. Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Cancer Center Clinica Universidad de Navarra (CCUN), IdiSNA, Pamplona, Spain., Ellmeier W; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Vienna, Austria., Busch D; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany., Visekruna A; Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany., Slingerland J; City of Hope Comprehensive Cancer Center, Duarte, CA., Shouval R; Adult Bone Marrow Transplantation Service and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York., Hiller K; Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany., van den Brink M; City of Hope Comprehensive Cancer Center, Duarte, CA., Pausch P; Life Sciences Center - European Molecular Biology Laboratory (LSC-EMBL) Partnership for Genome Editing Technologies, Vilnius University - Life Sciences Center, Vilnius University, Vilnius, Lithuania., Neri P; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Hudecek M; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.; Bavarian Cancer Research Center (BZKF), Regensburg & Würzburg, Germany., Poeck H; University Hospital Regensburg, Department of Internal Medicine III, Hematology & Internal Oncology, Regensburg, Germany.; Bavarian Cancer Research Center (BZKF), Regensburg & Würzburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Luu M; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.