Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates

Autor: Justinova, Z, Mangieri, RA, Bortolato, M, Chefer, SI, Mukhin, AG, Clapper, JR, King, AR, Redhi, GH, Yasar, S, Piomelli, D, Goldberg, SR

Publikováno v: Justinova, Z; Mangieri, RA; Bortolato, M; Chefer, SI; Mukhin, AG; Clapper, JR; et al.(2008). Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates. Biological Psychiatry, 64(11), 930-937. doi: 10.1016/j.biopsych.2008.08.008. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0pq080ms

Background: CB1cannabinoid receptors in the brain are known to participate in the regulation of reward-based behaviors. However, the contribution of each of the endocannabinoid transmitters, anandamide and 2-arachidonoylglycerol (2-AG), to these beha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5a6e659def6ee81578223004131df214
http://www.escholarship.org/uc/item/0pq080ms

Time-course concentration of ethanol, acetaldehyde and acetate in rat brain dialysate following alcohol self-administration.

Autor: Lee TA; Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX 78712, USA., Lee HJ; Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA., Mangieri RA; College of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX 78712, USA., Gonzales R; College of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX 78712, USA., Ajmal H; Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA., Hutter T; Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Materials Science and Engineering Program and Texas Materials Institute, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: tanya.hutter@utexas.edu.

Publikováno v: Alcohol (Fayetteville, N.Y.) [Alcohol] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.

Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice.

Autor: Plasil SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Farris SP; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA., Blednov Y; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA., Mayfield RD; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA., Mangieri RA; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA., Nwokeji UJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Aziz HC; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA., Lambeth PS; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA., Harris RA; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA., Homanics GE; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Publikováno v: Genes, brain, and behavior [Genes Brain Behav] 2024 Feb; Vol. 23 (1), pp. e12886.

Preclinical and clinical evidence for suppression of alcohol intake by apremilast.

Autor: Grigsby KB; Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, and VA Portland Health Care System, Portland, Oregon, USA., Mangieri RA; Waggoner Center for Alcohol and Addiction Research, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA., Roberts AJ; Animal Models Core Facility, The Scripps Research Institute, La Jolla, California, USA., Lopez MF; Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA., Firsick EJ; Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, and VA Portland Health Care System, Portland, Oregon, USA., Townsley KG; Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, and VA Portland Health Care System, Portland, Oregon, USA., Beneze A; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Bess J; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Eisenstein TK; Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Meissler JJ; Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Light JM; Oregon Research Institute, Eugene, Oregon, USA., Miller J; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Quello S; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Shadan F; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Skinner M; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Aziz HC; Waggoner Center for Alcohol and Addiction Research, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA., Metten P; Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, and VA Portland Health Care System, Portland, Oregon, USA., Morrisett RA; Waggoner Center for Alcohol and Addiction Research, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA., Crabbe JC; Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, and VA Portland Health Care System, Portland, Oregon, USA., Roberto M; Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA., Becker HC; Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.; RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina, USA., Mason BJ; Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Ozburn AR; Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, and VA Portland Health Care System, Portland, Oregon, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Mar 15; Vol. 133 (6). Date of Electronic Publication: 2023 Mar 15.

Editorial: The Jilted Brain: Neglected Structures and Functions.

Autor: Mangieri RA; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, United States., Allers KA; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Zahr NM; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States.

Publikováno v: Frontiers in systems neuroscience [Front Syst Neurosci] 2021 Aug 11; Vol. 15, pp. 716242. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).