Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mangesh Fulsunder"'
Autor:
David McKenney, Louis E. Metzger, Dirksen E. Bussiere, Sylvia Ma, Ashish Patel, Bhavesh Dhumale, Upendra Kulkarni, Jay Parthiban Lakshman, Sean King, Duncan Armstrong, Kyuto Tashiro, Lauren Kossy, Tushar Patel, Lauren M. Holder, Jogitha Selvarajah, Sarah Williams, Satya Yendluri, Colin Osborne, Jason Vo, Mangesh Fulsunder, Xiaolan Ling, Laura Wedel, Gianfranco De Pascale, Jennifer A. Leeds, Cody Cepura, Heinz E. Moser, Alexey Rivkin, Sunil Namballa, Colin K. Skepper, Bhavin Kantariya, Mina Mostafavi, Bhautik Savani, Anatoli Lvov, Guillaume Lapointe, Cornelia Bellamacina, Bhavesh Vora, Daryl L. Richie, Helen Chan, Wosenu Mergo, Jianwei Bian, Wei Shu, Keshav Mhaske, Aregahegn Yifru, Mark R. Sanderson, Swapnil Malekar, Johanne Blais, Qin Yue, Yong Zhang, Katherine V. Thompson, Julie Kim, Charles R. Dean, Vijay Sethuraman, Trixie Wagner, L. Mark Fisher, Dennis A. Veselkov, Darshit Patel, Folkert Reck, Jonas Noeske, Krishniah Vaarla, Lakhan Vala, Shailesh Satasia, Krunal Prajapati, Philippe Piechon, Valery Polyakov, Katherine R Prosen
Publikováno v:
Lapointe, G, Skepper, C K, Holder, L M, Armstrong, D, Bellamacina, C, Blais, J, Bussiere, D, Bian, J, Cepura, C, Chan, H, Dean, C R, De Pascale, G, Dhumale, B, Fisher, L M, Fulsunder, M, Kantariya, B, Kim, J, King, S, Kossy, L, Kulkarni, U, Lakshman, J, Leeds, J A, Ling, X, Lvov, A, Ma, S, Malekar, S, McKenney, D, Mergo, W, Metzger, L, Mhaske, K, Moser, H E, Mostafavi, M, Namballa, S, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Piechon, P, Polyakov, V, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Sanderson, M R, Satasia, S, Savani, B, Selvarajah, J, Sethuraman, V, Shu, W, Tashiro, K, Thompson, K V, Vaarla, K, Vala, L, Veselkov, D A, Vo, J, Vora, B, Wagner, T, Wedel, L, Williams, S L, Yendluri, S, Yue, Q, Yifru, A, Zhang, Y & Rivkin, A 2021, ' Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria ', Journal of Medicinal Chemistry, vol. 64, no. 9, pp. 6329-6357 . https://doi.org/10.1021/acs.jmedchem.1c00375
Herein, we describe the discovery and optimization of a novel series that inhibits bacterial DNA gyrase and topoisomerase IV via binding to, and stabilization of, DNA cleavage complexes. Optimization of this series led to the identification of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56db96726415696056387173baa99222
https://kclpure.kcl.ac.uk/en/publications/675d57ab-71d9-4244-886c-019cc57306cd
https://kclpure.kcl.ac.uk/en/publications/675d57ab-71d9-4244-886c-019cc57306cd
Autor:
Xiaolin Li, Martin Traebert, David McKenney, Dirksen E. Bussiere, Sylvia Ma, Katherine V. Thompson, Nirav Shah, Douglas C. Bauer, Wosenu Mergo, Duncan Armstrong, Richard Zang, Bhavin Kantariya, Jennifer A. Leeds, Bo Zhou, Ashish Patel, John Fuller, Tushar Patel, Alice Rico, William S. Sawyer, Colin Osborne, Heinz E. Moser, Mangesh Fulsunder, Yongjin Xu, Bret Benton, Swapnil Malekar, Shravanthi Madhavan, Jason Vo, Cheng Hu, Daniel Mutnick, Krunal Prajapati, Michael Wang, Katherine R Prosen, Louis E. Metzger, Carl J. Balibar, Darshit Patel, Jogitha Selvarajah, Sarah Williams, Shailesh Satasia, Peichao Lu, Bhavesh Dhumale, Kartik Shanghavi, Alexey Rivkin, Javier de Vicente, Wei Shu, Jonas Noeske, Anand Vala, Mark R. Sanderson, Cornelia Bellamacina, L. Mark Fisher, Lakhan Vala, Qin Yue, Charles R. Dean, Gianfranco De Pascale, Dennis A. Veselkov, Marcella Widya, Folkert Reck, Lauren M. Holder, Guillaume Lapointe, Colin K. Skepper, Daryl L. Richie, Anatoli Lvov
Publikováno v:
Skepper, C K, Armstrong, D, Balibar, C J, Bauer, D, Bellamacina, C, Benton, B M, Bussiere, D, De Pascale, G, De Vicente, J, Dean, C R, Dhumale, B, Fisher, L M, Fuller, J, Fulsunder, M, Holder, L M, Hu, C, Kantariya, B, Lapointe, G, Leeds, J A, Li, X, Lu, P, Lvov, A, Ma, S, Madhavan, S, Malekar, S, Mckenney, D, Mergo, W, Metzger, L, Moser, H E, Mutnick, D, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Rico, A, Sanderson, M R, Satasia, S, Sawyer, W S, Selvarajah, J, Shah, N, Shanghavi, K, Shu, W, Thompson, K V, Veselkov, D A, Williams, S L, Xu, Y, Yue, Q, Zang, R, Zho, B & Rivkin, A 2020, ' Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria ', Journal of Medicinal Chemistry, vol. 63, no. 14, pp. 7773-7816 . https://doi.org/10.1021/acs.jmedchem.0c00347
Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99afdf67109b37c858dc407505690414
https://kclpure.kcl.ac.uk/ws/files/133475695/Topoisomerase_Inhibitors_Addressing_Fluoroquinolone_SKEPPER_Acc16Jun2020E_ub7Jul2020_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/133475695/Topoisomerase_Inhibitors_Addressing_Fluoroquinolone_SKEPPER_Acc16Jun2020E_ub7Jul2020_GREEN_AAM.pdf
Autor:
Skepper, Colin K., Armstrong, Duncan, Balibar, Carl J., Bauer, Daniel, Bellamacina, Cornelia, Benton, Bret M., Bussiere, Dirksen, De Pascale, Gianfranco, De Vicente, Javier, Dean, Charles R., Bhavesh Dhumale, Fisher, L. Mark, Fuller, John, Mangesh Fulsunder, Holder, Lauren M., Cheng Hu, Bhavin Kantariya, Guillaume Lapointe, Leeds, Jennifer A., Xiaolin Li
Publikováno v:
Journal of Medicinal Chemistry; 7/23/2020, Vol. 63 Issue 14, p7773-7816, 44p
