Exploring the Utility of Urinary Creatinine Adjustment for KIM-1, NGAL, and Cystatin C for the Assessment of Kidney Function: Insights from the C-KidnEES Cohort

Autor: T. D. K. S. C. Gunasekara, Chula Herath, P. Mangala C. S. De Silva, Nishad Jayasundara

Publikováno v: Children, Vol 11, Iss 1, p 15 (2023)

Normalization of urinary biomarkers of kidney injury is a common practice in clinical and research settings to account for variations in urine concentration, and urinary creatinine is often used as a reference. However, to date, there is no consensus

Externí odkaz: https://doaj.org/article/fe60e67484eb4dad87f45ef2f227ba4a

The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)

Autor: Ramya T. Kolli, Sameera Chathuranga Gunasekara, Matthew W. Foster, Sitaramaraju Adduri, Anna Strasma, Christina Wyatt, Nagarjun V. Konduru, Mangala C. S. De Silva, Nishad Jayasundara

Publikováno v: American Journal of Physiology-Renal Physiology. 324:F387-F403

CKDu is a global health concern debilitating a number of tropical rural farming communities. In the absence of typical risk factors like diabetes and hypertension and the lack of molecular markers, it is crucial to identify potential early disease ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18c0d3a57d10aef2cda88e2b5eacd385
https://doi.org/10.1152/ajprenal.00285.2022

Global Geographical Variation in Elemental and Arsenic Species Concentration in Paddy Rice Grain Identifies a Close Association of Essential Elements Copper, Selenium and Molybdenum with Cadmium

Autor: Andrew A. Meharg, Caroline Meharg, Manus Carey, Paul Williams, Zhengyu Shi, Katrina Campbell, Christopher Elliott, Ernest Marwa, Xiao Jiujin, Júlia Gomes Farias, Fernando Teixeira Nicoloso, P. Mangala C. S. De Silva, Ying Lu, Andy J. Green, Eduardo Moreno-Jiménez, Ángel Antonio Carbonell-Barrachina, Alessia Sommella, Massimo Pigna, Catherine Brabet, Didier Montet, Mahmud Hossain, M. Rafiqul Islam

Publikováno v: Meharg, A A, Meharg, C, Carey, M, Williams, P, Shi, Z, Campbell, K, Elliott, C, Marwa, E, Jiujin, X, Farias, J G, Nicoloso, F T, De Silva, P M C S, Lu, Y, Green, A J, Moreno-Jiménez, E, Carbonell-Barrachina, Á A, Sommella, A, Pigna, M, Brabet, C, Montet, D, Hossain, M & Islam, M R 2022, ' Global geographical variation in elemental and arsenic species concentration in paddy rice grain identifies a close association of essential elements copper, selenium and molybdenum with cadmium ', Exposure and Health . https://doi.org/10.1007/s12403-022-00504-1

Despite the centrality of staple grains for human well-being, both as a source of nutrients and of toxic ions, there is little understanding of where and how elements vary, and if there are particular elements that correlate. Here, for shop bought po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee4bc79a4cb98a3385de83ebb37f6bc
https://doi.org/10.1007/s12403-022-00504-1

Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka.

Autor: Pallagae Mangala C S De Silva, Khaja Shameem Mohammed Abdul, Eakanayake M D V Eakanayake, Sudheera Sammanthi Jayasinghe, Channa Jayasumana, Hewa Bandulage Asanthi, Hettiarachigae S D Perera, Gamage G Tushara Chaminda, Ediriweera P S Chandana, Sisira H Siribaddana

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004979 (2016)

Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial d

Externí odkaz: https://doaj.org/article/04a094c1f2854302b9df26abcebf85d7

A review of molecular mechanisms linked to potential renal injury agents in tropical rural farming communities

Autor: Samarawickrama Wanni Arachchige Madushani, Upamalika, Champi Thusangi, Wannige, Sugandima Mihirani, Vidanagamachchi, Sameera Chathuranga, Gunasekara, Ramya Tulasi, Kolli, P Mangala C S, De Silva, Don, Kulasiri, Nishad, Jayasundara

Publikováno v: Environmental Toxicology and Pharmacology. 92:103850

The chronic kidney disease of unknown etiology (CKDu) is a global health concern primarily impacting tropical farming communities. Although the precise etiology is debated, CKDu is associated with environmental exposures including heat stress and che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738306449fea82d4536703d0b6288a9e
https://doi.org/10.1016/j.etap.2022.103850