Výsledky vyhledávání - "Manfredi Ponente"

Supplementary Figure 3 from Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα–Driven Leukemia

Autor: Rosa Bernardi, Maurilio Ponzoni, Manfredi Ponente, Roberta Valsecchi, Nadia Coltella

Supplementary Figure 3: EZN-2208 affects leukemic stromal cell numbers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcf07d7baf31dd2cc976a85a21db500
https://doi.org/10.1158/1078-0432.22457192.v1

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Supplementary Figure 4 from Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα–Driven Leukemia

Autor: Rosa Bernardi, Maurilio Ponzoni, Manfredi Ponente, Roberta Valsecchi, Nadia Coltella

Supplementary Figure 4: Combined effect of EZN-2208 and ATRA on NB4 cell viability and differentiation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09777fe46fdd8be498c48a47c4e399f0
https://doi.org/10.1158/1078-0432.22457189

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Supplementary Figure 1 from Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα–Driven Leukemia

Autor: Rosa Bernardi, Maurilio Ponzoni, Manfredi Ponente, Roberta Valsecchi, Nadia Coltella

Supplementary Figure 1: EZN-2208 does not impair cell migration and colony formation in U937-MT control cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62c55461fa457c6c7fabfb9737f25cc
https://doi.org/10.1158/1078-0432.22457198.v1

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Supplementary Figure 2 from Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα–Driven Leukemia

Autor: Rosa Bernardi, Maurilio Ponzoni, Manfredi Ponente, Roberta Valsecchi, Nadia Coltella

Supplementary Figure 2: High doses EZN-2208 induce apoptosis in leukemic bone marrow cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822a5c55a5aa660f3345707c694ba571
https://doi.org/10.1158/1078-0432.22457195.v1

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Data from Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα–Driven Leukemia

Autor: Rosa Bernardi, Maurilio Ponzoni, Manfredi Ponente, Roberta Valsecchi, Nadia Coltella

Purpose: Retinoic acid-arsenic trioxide (ATRA-ATO) combination therapy is the current standard of care for patients with acute promyelocytic leukemia (APL) carrying the oncogenic fusion protein PML-RARα. Despite the high cure rates obtained with thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a880407d85e18676f81aaeede2ff5b3f
https://doi.org/10.1158/1078-0432.c.6523532

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PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes

Autor: Giacomo A. Delledonne, Linda Pattini, Roberto Cuttano, Claudio Doglioni, Letizia Campanini, Ugo Cavallaro, Nadia Coltella, Manfredi Ponente, Alessandra Villa, Rosa Bernardi, Roberta Valsecchi, Andrea Piunti

Publikováno v: JCI Insight

Elucidating the molecular basis of tumor metastasis is pivotal for eradicating cancer-related mortality. Triple-negative breast cancer (TNBC) encompasses a class of aggressive tumors characterized by high rates of recurrence and metastasis, as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87638df7b251ac68e547defd7f686aeb
https://europepmc.org/articles/PMC5313064/

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HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

Autor: Maria Teresa Sabrina Bertilaccio, Federico Caligaris-Cappio, Manfredi Ponente, Paola Brambilla, Giovanni Tonon, Rosa Bernardi, Elisabetta Ferrero, Filippo Martinelli Boneschi, Paolo Ghia, Maurilio Ponzoni, Marina Ferrarini, Andrea Brendolan, Elisa Lenti, Elisa Ten Hacken, Lydia Scarfò, Cristina Scielzo, Daniela Belloni, Roberta Valsecchi, Nadia Coltella

Hypoxia-inducible transcription factors (HIFs) regulate a wide array of adaptive responses to hypoxia and are often activated in solid tumors and hematologic malignancies due to intratumoral hypoxia and emerging new layers of regulation. We found tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897a46a38b28cf0c0813a283e31eccfd
http://www.bloodjournal.org/content/bloodjournal/127/16/1987.full.pdf

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Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα-Driven Leukemia

Autor: Nadia Coltella, Rosa Bernardi, Maurilio Ponzoni, Manfredi Ponente, Roberta Valsecchi

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 21(16)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33ace1f15d178cb883418a21854bd50
https://pubmed.ncbi.nlm.nih.gov/25931453

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