Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Manfredi Miraula"'
Autor:
Thomas Brück, Manfredi Miraula, Stefan Krco, James A. Larrabee, Liam A. Wilson, Luke W. Guddat, Esmée Gianna Knaven, Christopher Selleck, Nataša Mitić, Alice Clark, Gerhard Schenk, Marcelo Monteiro Pedroso
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Genes that confer antibiotic resistance can rapidly be disseminated from one microorganism to another by mobile genetic elements, thus transferring resistance to previously susceptible bacterial strains. The misuse of antibiotics in health care and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59e473babec157e611a0c14754988fc
Publikováno v:
Journal of Inorganic Biochemistry. 162:366-375
MIM-1 and MIM-2 are two recently identified metallo-β-lactamases (MBLs) from Novosphingobium pentaromativorans and Simiduia agarivorans, respectively. Since these organisms are non-pathogenic we speculated that the biological role(s) of MIM-1 and MI
Autor:
David L. Paterson, Timothy R. Walsh, Maud E. S. Achard, Steven J. Hancock, Nataša Mitić, Karrera Y. Djoko, Kate M. Peters, Patrick N A Harris, Gregory J. Anderson, Minh-Duy Phan, William M. Shafer, Sasiprapa Prombhul, Mark A. Schembri, Hanna E. Sidjabat, Gerhard Schenk, Alvin W. Lo, Manfredi Miraula, Alastair G. McEwan
Publikováno v:
Antimicrobial agents and chemotherapy, 2018, Vol.62(2), pp.e02280-17 [Peer Reviewed Journal]
Carbapenem-resistantEnterobacteriaceaeare urgent threats to global human health. These organisms produce β-lactamases with carbapenemase activity, such as the metallo-β-lactamase NDM-1, which is notable due to its association with mobile genetic el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cae253d49c697a82eaf49be6a88c6da
http://dro.dur.ac.uk/23538/
http://dro.dur.ac.uk/23538/
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 20:739-755
Urease is a Ni(II) enzyme present in every domain of life, in charge for nitrogen recycling through urea hydrolysis. Its activity requires the presence of two Ni(II) ions in the active site. These are delivered by the concerted action of four accesso
Publikováno v:
American Journal of Molecular Biology. :42-56
The main aim of this mini-review is to illustrate strategies and industrial applications based on inteins (INTErnal proteINS), which belong to a class of autocatalytic enzymes that are able to perform a catalytic reaction on a single substrate. Howev
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 19:833-852
Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that are very effective in inactivating most of the commonly used β-lactams antibiotics. They have emerged as a major threat to global health care. Recently, we identified two nov
Autor:
Gerhard Schenk, Christopher Selleck, Manfredi Miraula, Emer K. Phelan, Nataša Mitić, David L. Ollis
Publikováno v:
American Journal of Molecular Biology. :89-104
Antibiotic resistance is one of the most significant challenges facing global healthcare. Since the 1940s, antibiotics have been used to fight infections, initially with penicillin and subsequently with various derivatives including cephalosporins, c
Autor:
Nataša Mitić, David L. Ollis, Chun-Feng David Hou, Emer K. Phelan, Gerhard Schenk, Manfredi Miraula
Publikováno v:
American Journal of Molecular Biology. :11-15
Metallo-β-lactamases (MBLs) are a family of Zn2+-dependent enzymes that have contributed strongly to the emergence and spread of antibiotic resistance. Novel members as well as variants of existing members of this family are discovered continuously,
Autor:
David L. Ollis, Fernanda Ely, Gerhard Schenk, Peter Vella, Eleanor W. W. Leung, Manfredi Miraula, Emer K. Phelan, Nataša Mitić, Ross P. McGeary
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 18:855-863
Metallo-β-lactamases (MBLs) are a family of metalloenzymes that are capable of hydrolyzing β-lactam antibiotics and are an important means by which bacterial pathogens use to inactivate antibiotics. A database search of the available amino acid seq
Publikováno v:
American Journal of Molecular Biology. :198-203
Antibiotic resistance has emerged as a major global threat to human health. Among the strategies employed by pathogens to acquire resistance the use of metallo-β-lactamases (MBLs), a family of dinuclear metalloenzymes, is among the most potent. MBLs