Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Manfred Weigele"'
Autor:
Tomi K. Sawyer, Regine S. Bohacek, Chester A. Metcalf III, William C. Shakespeare, Yihan Wang, Raji Sundaramoorthi, Terence Keenan, Surinder Narula, Manfred Weigele, David C. Dalgarno
Publikováno v:
BioTechniques, Vol 34, Iss 6S, Pp S2-S15 (2003)
Externí odkaz:
https://doaj.org/article/2a7a4be570f14a5eb30fe9249ca4314e
Autor:
Benjamin Wolozin, Rachel M. Squillace, Aki Takashima, Hu Li, James J. Collins, Maria Guillily, Katelyn Smith, Manfred Weigele, Andrew Ferree
Publikováno v:
Neurodegenerative Diseases. 10:238-241
Background: Mutations in LRRK2 are associated with familial and sporadic Parkinson’s disease (PD). Subjects with PD caused by LRRK2 mutations show pleiotropic pathology that can involve inclusions containing α-synuclein, tau or neither protein. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd076f996c3fdbb74d3c7a8936565b68
https://doi.org/10.1159/000332599
https://doi.org/10.1159/000332599
Autor:
Selvi Pradeepan, Chet Metcalf, Brendan F. Boyce, Shuangying Liu, Manfred Weigele, Surinder S. Narula, Regine S. Bohacek, Lianping Xing, Raji Sundaramoorthi, Jeff Keats, Julie Bogus, Jennifer Saltmarsh, Yihan Wang, Scott Wardwell, Mary K. Ram, David C. Dalgarno, John Iuliucci, Susan Adams, Guru Paramanathan, Shuenn Liou, Marie Rose van Schravendijk, Anne Dilauro, Sonya Roeloffzen, T. Keenan, William C. Shakespeare, Tomi K. Sawyer
Publikováno v:
Chemical Biology & Drug Design. 71:97-105
Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Here, we describe structure acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcdeae0a92758c4ad04f2c1f5760a13
https://doi.org/10.1111/j.1747-0285.2007.00615.x
https://doi.org/10.1111/j.1747-0285.2007.00615.x
Autor:
Selvi Pradeepan, Taylor Merry, Shelia Violette, Surinder S. Narula, Noriyuki Kawahata, Yihan Wang, Tomi K. Sawyer, David C. Dalgarno, Susan Adams, George P. Luke, Terence P. Keenan, Regine S. Bohacek, Wei Guan, Marie Rose van Schravendijk, Raji Sundaramoorthi, Jeffrey A. Keats, Mary K. Ram, Evelyn G. Corpuz, Chi B. Vu, Manfred Weigele, Chester A. Metcalf, Shuenn Liou, William C. Shakespeare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3071-3074
The design of bone-targeted pyrido[2,3-d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using structure-based methods, we were able to rapidly incorporate bone binding components, which mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557b75ac7c90bb0fb12e38e1f0a1e1cc
https://doi.org/10.1016/s0960-894x(03)00649-8
https://doi.org/10.1016/s0960-894x(03)00649-8
Autor:
David C. Dalgarno, Surinder S. Narula, Terence P. Keenan, Tomi K. Sawyer, Regine S. Bohacek, William C. Shakespeare, Chester A. Metcalf, Raji Sundaramoorthi, Yihan Wang, Manfred Weigele
Publikováno v:
BioTechniques. 34:S2-S15
In retrospect, the emergence of protein kinase drug discovery dates to the identification of the first oncogenic protein kinase, Src, about 25 years ago. This work has led to worldwide research efforts to investigate the genomic and proteomic relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db91a14d17fed30378777b30369b8d2
https://doi.org/10.2144/sawyerjun03revised
https://doi.org/10.2144/sawyerjun03revised
Autor:
Regine S. Bohacek, Karina J. Macek, Manfred Weigele, Marcos Hatada, Tomi K. Sawyer, William C. Shakespeare, Chester A. Metcalf, David C. Dalgarno, Berkley A. Lynch, Surinder S. Narula, Taylor Merry, Shelia Violette, Virginia A. Jacobsen
Publikováno v:
Journal of Medicinal Chemistry. 44:660-663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b98587a3d11d3c4fde1d366bbe4bc3c
https://doi.org/10.1021/jm0002681
https://doi.org/10.1021/jm0002681
Autor:
Roland Baron, Virginia A. Jacobsen, Shelia Violette, Catherine Bartlett, E Antoine, Craig S. Takeuchi, C. Bardelay, Dominique Lesuisse, Tomi K. Sawyer, Richard J. Rickles, David C. Dalgarno, Michael G. Yang, William C. Shakespeare, Berkley A. Lynch, Regine S. Bohacek, Karina J. Macek, Wei Guan, Susan Adams, Eliane Mandine, Jeremy Smith, Manfred Weigele, M.R van Schravendijk
Publikováno v:
Bone. 28:54-64
Src, a nonreceptor tyrosine kinase, is an important regulator of osteoclast-mediated resorption. We have investigated whether compounds that bind to the Src SH2 domain inhibit Src activity in cells and decrease osteoclast-mediated resorption. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdc7ba176469b510c6a46ae720c9f68
https://doi.org/10.1016/s8756-3282(00)00427-0
https://doi.org/10.1016/s8756-3282(00)00427-0
Autor:
V. Fallat, J. Siebelist, D. H. Mcgarry, Manfred Weigele, Roxana Yang, Dennis D. Keith, G. Beskid, N H Georgopapadakou, J. W. Durkin, E. R. Lipschitz, Konzelmann Frederick Martin, Chung-Chen Wei, Harry Allen Albrecht, J. G. Christenson
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::213f8b0fe2f8be2fc1d2a29e2c9412e2
https://doi.org/10.1002/chin.199138275
https://doi.org/10.1002/chin.199138275
Publikováno v:
ChemInform. 24
Synthesis of the 1,1-dicyanomethylene-1-dethiacephalosporin 1a is described. Substitution of the dicyanomethylene moiety for sulfur at position 1 of the cephem nucleus resulted in a highly reactive β-lactam antibacterial.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11017a90f5255af1de7ddd153bec6477
https://doi.org/10.1002/chin.199310280
https://doi.org/10.1002/chin.199310280
Autor:
Louis J. Todaro, Iain S. Sim, Manfred Weigele, Donna M. Huryn, Samuel Broder, Tam Steve Yik-Kai, Barbara C. Sluboski, Douglas D. Richman, Hiroaki Mitsuya, Karl Frank
Publikováno v:
Annals of the New York Academy of Sciences. 616:530-534
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66ebc6f9d58c84824a5506b906d422c
https://doi.org/10.1111/j.1749-6632.1990.tb17885.x
https://doi.org/10.1111/j.1749-6632.1990.tb17885.x