Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Manfred Volm"'
Autor:
Manfred Volm, Jürgen Mattern, Felix Zintl, Silke Meinhardt, Axel Sauerbrey, Yi-Fen Wang, V. Badireenath Konkimalla, Thomas Efferth
Supplementary Tables S1-S5 from Prediction of Broad Spectrum Resistance of Tumors towards Anticancer Drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e3922a3cb5e43198d446f3607baf95
https://doi.org/10.1158/1078-0432.22439841
https://doi.org/10.1158/1078-0432.22439841
Autor:
Manfred Volm, Jürgen Mattern, Felix Zintl, Silke Meinhardt, Axel Sauerbrey, Yi-Fen Wang, V. Badireenath Konkimalla, Thomas Efferth
Purpose: Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical probability of therapeutic success is known for larger patient groups from clinical therapy trials, it is difficult to predict the individual response of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ccc82847605d3574fec49732d4467f
https://doi.org/10.1158/1078-0432.c.6517248
https://doi.org/10.1158/1078-0432.c.6517248
Publikováno v:
International Journal of Medical Sciences, Vol 8, Iss 3, Pp 245-253 (2011)
Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance) or induced by the drugs (acquired resistance). At present, resistance is usually diagnosed during treatme
Externí odkaz:
https://doaj.org/article/5983b7c717cf4c6fad9356f00b338671
Publikováno v:
Synergy. 1:44-58
Summary Inhibition of P-glycoprotein represents an attractive possibility to modulate resistance of cancer cells to anticancer drugs. One major strategy to overcome P-glycoprotein-mediated multidrug resistance (MDR) of tumors is to increase intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c617e33e74de843fdc2cfde511b637f8
https://doi.org/10.1016/j.synres.2014.07.002
https://doi.org/10.1016/j.synres.2014.07.002
Publikováno v:
Arzneimittelforschung. 58:261-264
Drug resistance is the major reason for failure in cancer chemotherapy. Resistance may be either pre-existent (intrinsic resistance), or induced by drugs (acquired resistance), So far, no strategy has been found to overcome resistance, which is based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97af12099a3283fbdeead20d88814bbe
https://doi.org/10.1055/s-0031-1296504
https://doi.org/10.1055/s-0031-1296504
Publikováno v:
International Journal of Medical Sciences
Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance) or induced by the drugs (acquired resistance). At present, resistance is usually diagnosed during treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666af2685424ad2244319300a95d6ef5
https://doi.org/10.7150/ijms.8.245
https://doi.org/10.7150/ijms.8.245
Autor:
Axel Sauerbrey, Felix Zintl, Silke Meinhardt, V. Badireenath Konkimalla, Yi-Fen Wang, Jürgen Mattern, Manfred Volm, Thomas Efferth
Publikováno v:
Clinical Cancer Research. 14:2405-2412
Purpose: Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical probability of therapeutic success is known for larger patient groups from clinical therapy trials, it is difficult to predict the individual response of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd47ea1a1b8191a52bec160119dc1bd
https://doi.org/10.1158/1078-0432.ccr-07-4525
https://doi.org/10.1158/1078-0432.ccr-07-4525
Publikováno v:
Pharmacology. 81:196-203
The frequent resistance of malignant tumors to chemotherapy documents the fact that numerous patients are uselessly traumatized by highly toxic drugs. Investigations into this resistance have shown that many different mechanisms exist which can aboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b981d7f7b2f0eb0079b3c2f0719d70
https://doi.org/10.1159/000112864
https://doi.org/10.1159/000112864
Autor:
Manfred Volm, Thomas Efferth
Publikováno v:
Pharmacology & Therapeutics. 107:155-176
The same doses of medication cause considerable heterogeneity in efficacy and toxicity across human populations. Genetic factors are thought to represent important determinants of drug efficacy and toxicity. Pharmacogenetics focuses on the prediction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63c8b285a0fab0511f53559a228f277
https://doi.org/10.1016/j.pharmthera.2005.02.005
https://doi.org/10.1016/j.pharmthera.2005.02.005
Autor:
Manfred Volm, Pia Rauch, Erich Gebhart, Thomas Efferth, Kenneth D. Tew, H. Oliver Weber, Armin Olbrich, Jens Oliver Funk, Marc-Eric Halatsch, Douglas D. Ross, Jan G. Hengstler, Axel Sauerbrey
Publikováno v:
Molecular Pharmacology. 64:382-394
A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55 cancer cell lines of the U.S. National Cancer Institute (NCI). The 50% inhibition concentrations (IC50 values) for ART correlated significantly to the cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb26ebd08a5d3dde9e6319bd0d024db
https://doi.org/10.1124/mol.64.2.382
https://doi.org/10.1124/mol.64.2.382