Zobrazeno 1 - 10 of 924 pro vyhledávání: '"Manfred T. Reetz"'
1
Akademický článek
Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles
Autor: Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, Zhoutong Sun
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Chiral heterocyclic compounds are privileged structures in medicinal chemistry. Here, the authors report an in silico strategy for the enzymatic synthesis of pharmaceutically significant chiral N- and O-heterocycles via Baldwin cyclization of hydroxy
Externí odkaz: https://doaj.org/article/7aa8360322c843c2aeb21f8f5e69f98e
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3
Akademický článek
Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Autor: Carlos G. Acevedo-Rocha, Aitao Li, Lorenzo D’Amore, Sabrina Hoebenreich, Joaquin Sanchis, Paul Lubrano, Matteo P. Ferla, Marc Garcia-Borràs, Sílvia Osuna, Manfred T. Reetz
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Connecting conformational dynamics and epistasis has so far been limited to a few proteins and a single fitness trait. Here, the authors provide evidence of positive epistasis on multiple catalytic traits in the evolution and dynamics of engineered c
Externí odkaz: https://doaj.org/article/4402820afefc4a3885f8088826bfca5b
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4
Akademický článek
Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution
Autor: Yixin Cen, Warispreet Singh, Mamatjan Arkin, Thomas S. Moody, Meilan Huang, Jiahai Zhou, Qi Wu, Manfred T. Reetz
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Candida antarctica lipase B (CALB) is a serine lipase. Here, the authors use directed evolution to exchange serine with cysteine in the catalytic triad of the enzyme, thereby obtaining a highly active CALB variant that — unlike the wild type — ac
Externí odkaz: https://doaj.org/article/382d844422024dc1aad5ab0dfe4e992c
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6
Akademický článek
A breakthrough in protein engineering of a glycosyltransferase
Autor: Manfred T. Reetz
Publikováno v: Green Synthesis and Catalysis, Vol 2, Iss 1, Pp 4-5 (2021)
An intriguing advance in the rational protein engineering of a newly identified glycosyltransferase from Siraitia grosvenorii (UGT74AC2) has been accomplished by Zhoutong Sun, Yuanxia Sun and coworkers for the targeted pharmaceutically significant gl
Externí odkaz: https://doaj.org/article/349b368b2ccc44b587d90d4b133f8bc1
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7
Akademický článek
A redox-mediated Kemp eliminase
Autor: Aitao Li, Binju Wang, Adriana Ilie, Kshatresh D. Dubey, Gert Bange, Ivan V. Korendovych, Sason Shaik, Manfred T. Reetz
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into e
Externí odkaz: https://doaj.org/article/aa51e79cc994447a82719af128acff74
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