Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Manfred Rösner"'
Autor:
Edward Arnold, Gunther Riess, Stephen H. Hughes, Irvin Winkler, Y. Hsiou, Arthur D. Clark, Manfred Rösner, Jianping Ding, Kalyan Das, Jörg Peter Kleim
Publikováno v:
Journal of Molecular Biology. 284:313-323
The second generation Hoechst-Bayer non-nucleoside inhibitor, HBY 097 ( S -4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroqui noxalin-2(1 H )-thione), is an extremely potent inhibitor of HIV-1 reverse transcriptase (RT) and of HIV-1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::675e6c1f84870479982496e24bdcd132
https://doi.org/10.1006/jmbi.1998.2171
https://doi.org/10.1006/jmbi.1998.2171
Autor:
Y. Hsiou, Reinhard Kirsch, Irvin Winkler, Gunther Riess, Manfred Rösner, Edward Arnold, Arno Paessens, Jorg-Peter Kleim
Publikováno v:
Proceedings of the National Academy of Sciences. 93:34-38
The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd7089bd332ff10f9b78508a768626d
https://doi.org/10.1073/pnas.93.1.34
https://doi.org/10.1073/pnas.93.1.34
Autor:
Gerhard Jähne, Otto Holzhäuser, Irvin Winkler, Günther Rieß, Herbert Kroha, Matthias Helsberg, Manfred Rösner, Armin Müller, Christoph Dr Meichsner
Publikováno v:
Tetrahedron Letters. 33:5335-5338
A versatile and high-yielding synthesis of racemic carbocyclic phosphonate nucleosides of adenine, hypoxanthine, guanine, cytosine, uracil, and thymine has been developed. These newly prepared compounds are isosteric (and isoelectronic) with (carbo)c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7438d9aed2bc9a0defd9434bdf3a346d
https://doi.org/10.1016/s0040-4039(00)79086-1
https://doi.org/10.1016/s0040-4039(00)79086-1
Autor:
Stephen H. Hughes, Paul L. Boyer, Arthur D. Clark, Jianping Ding, Manfred Rösner, Paul J. Lewi, Kalyan Das, Paul A. J. Janssen, Jorg-Peter Kleim, Y. Hsiou, Edward Arnold
Publikováno v:
Journal of molecular biology. 309(2)
Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the treatment of HIV infection. Loviride (an alpha-APA derivative) and HBY 097 (a quinoxaline derivative) are two potent non-nucleoside RT inhibitors (NNRT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ef6b17c765fdd8d9b1275d9257b13e
https://pubmed.ncbi.nlm.nih.gov/11371163
https://pubmed.ncbi.nlm.nih.gov/11371163
Autor:
Jörg-Peter Kleim, Arno Paessens, Manfred Rösner, Gunther Riess, Reinhard Kirsch, Helga Rübsamen-Waigmann, Irvin Winkler
Publikováno v:
Virology. 231(1)
In vitro resistance of HIV-1 against high levels of HBY 097 (( S )-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydro-quinoxaline-2(1 H )-thione) and other quinoxaline nonnucleoside reverse transcriptase inhibitors (NNRTIs) is characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a42e42e0416c740d0c4123e60002594
https://pubmed.ncbi.nlm.nih.gov/9143309
https://pubmed.ncbi.nlm.nih.gov/9143309
Publikováno v:
Chemische Berichte. 112:1879-1888
Es wird uber eine in guten Ausbeuten verlaufende stereoselektive Synthese des pentacyclischen Cyclopropanlactams 8 berichtet. Reactions with Indole Derivatives, XXXVII. Stereoselective Synthesis of Polycyclic Cyclopropane Derivatives in the Indoloqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ef26ee5962c03cebc649118bc8c3896
https://doi.org/10.1002/cber.19791120539
https://doi.org/10.1002/cber.19791120539
Publikováno v:
Helvetica Chimica Acta. 63:406-412
Revision der Struktur von «Epoxycolchicin» Die fur naturliches «Epoxycolchicin» vorgeschlagene Struktur 2 muss aufgrund einer Kristall-Rontgenstrukturanalyse zu derjenigen des cyclischen Acetals 3 abgeandert werden. Es wird vorgeschlagen, den Nam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::133edd005263ec900492be3fe2bed7e9
https://doi.org/10.1002/hlca.19800630211
https://doi.org/10.1002/hlca.19800630211
Publikováno v:
Chemische Berichte. 112:1889-1901
Die protonenkatalysierte und die nucleophile Ringoffnung der Cyclopropanlactame 1 und 2 werden studiert und die Stereospezifitat beschrieben. Die auf diese Weise erhaltenen Ketolactame 22 und 23 sind wichtige Zwischenprodukte. Reactions with Indole D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b67839d65ae7897cd9bb2722438693
https://doi.org/10.1002/cber.19791120540
https://doi.org/10.1002/cber.19791120540
Autor:
Gisela Rissmann, Gert Köbrich, Manfred Rösner, Albrecht Mannschreck, Werner Zündorf, Ram A. Misra
Publikováno v:
Chemische Berichte. 105:3794-3806
The skew conformation of butadiene has the point group C2 and is therefore chiral. The chirality of butadienes has been demonstrated spectroscopically for the first time with four compounds, 7, 8, 9 and 11, whose preparation is described. Their bulky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c4e7ad643f4c64fb9618208a4e53e7b
https://doi.org/10.1002/cber.19721051207
https://doi.org/10.1002/cber.19721051207
Autor:
Manfred Rösner, Gert Köbrich
Publikováno v:
Angewandte Chemie. 87:715-717
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05cb15632f4857f06b6acc20df3e91d2
https://doi.org/10.1002/ange.19750871914
https://doi.org/10.1002/ange.19750871914