Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Autor: Manfred J. Oswald, Yechao Han, Han Li, Samuel Marashli, Deniz Nouri Oglo, Bhavya Ojha, Paul V. Naser, Zheng Gan, Rohini Kuner

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

The basal nucleus of Meynert (NBM) plays a role in cognition by modulating cortical circuits. Here, the authors demonstrate plasticity of the NBM upon tissue injury, and that activating NBM cholinergic-GABAergic projections to the prefrontal cortex a

Externí odkaz: https://doaj.org/article/3b6878ffa5fe489ba3c003279cc4dce6

Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis

Autor: Manfred J. Oswald, David N. Palmer, Graham W. Kay, Karen J. Barwell, Jonathan D. Cooper

Publikováno v: Neurobiology of Disease, Vol 32, Iss 1, Pp 50-65 (2008)

The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are fatal inherited neurodegenerative diseases. Sheep affected with the CLN6 form provide a valuable model to investigate underlying disease mechanisms from preclinical stages. Excitatory neur

Externí odkaz: https://doaj.org/article/71c07d56d650485f89b3b6a1fed309f0

Neurobiology of brain oscillations in acute and chronic pain

Autor: Rohini Kuner, Linette Liqi Tan, Manfred J. Oswald

Publikováno v: Trends in Neurosciences. 44:629-642

Pain is a complex perceptual phenomenon. Coordinated activity among local and distant brain networks is a central element of the neural underpinnings of pain. Brain oscillatory rhythms across diverse frequency ranges provide a functional substrate fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d284c26132ff9e3d45fabe64cf5f3a1e
https://doi.org/10.1016/j.tins.2021.05.003

Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum

Autor: John N. J. Reynolds, Riccardo Avvisati, Paul D. Dodson, Simon D. Fisher, Manfred J. Oswald, Jeffery R. Wickens, Yan-Feng Zhang

Publikováno v: Reynolds, J N J, Avvisati, R, Dodson, P D, Fisher, S D, Oswald, M J, Wickens, J R & Zhang, Y-F 2022, ' Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum ', Nature Communications, vol. 13, no. 1, 1296, pp. 1296 . https://doi.org/10.1038/s41467-022-28950-0

Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22cd4e4a24aeac04c9a67163b27c978
https://pubmed.ncbi.nlm.nih.gov/35277506

Repetitive non-invasive prefrontal stimulation reverses neuropathic pain via neural remodelling in mice

Autor: Yechao Han, Manfred J. Oswald, Linette Liqi Tan, Zheng Gan, Rohini Kuner, Paul V. Naser, Han Li

Publikováno v: Progress in Neurobiology. 201:102009

Chronic neuropathic pain presents a major challenge to pharmacological therapy and neurostimulation-based alternatives are gaining interest. Although invasive and non-invasive motor cortex stimulation has been the focus of several studies, very littl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d808a203c63487039918be106baee5
https://doi.org/10.1016/j.pneurobio.2021.102009