Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Manfred Gossen"'
Autor:
Junyao Zhang, Daniele Marciano, Lei Wang, Weiwei Wang, Manfred Gossen, Mengting Yang, Tingying Peng, Julien Gautrot, Xun Xu, Nan Ma
Publikováno v:
Advanced Materials Interfaces, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Lung diseases are one of the leading causes of global mortality. Advances in induced pluripotent stem cell (iPSC) differentiation have enabled the creation of bronchiolar and alveolar lung organoids, advancing research on lung conditions. Tr
Externí odkaz:
https://doaj.org/article/311b5d6aaad34c4fbc188054f9169acd
Publikováno v:
JMIR Medical Informatics, Vol 12, Pp e58478-e58478 (2024)
AbstractWith the popularization of large language models (LLMs), strategies for their effective and safe usage in health care and research have become increasingly pertinent. Despite the growing interest and eagerness among health care professionals
Externí odkaz:
https://doaj.org/article/61cc9936c8b947fca4cd82c66e264129
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Recent technological advances in the production of in vitro transcribed messenger RNA (IVT‐mRNA) facilitate its clinical use as well as its application in basic research. In this regard, numerous chemical modifications, which are not natur
Externí odkaz:
https://doaj.org/article/a0f075f2894a4596b98a60d9d9662fbb
Autor:
Norman M. Drzeniek, Nourhan Kahwaji, Samira Picht, Ioanna Maria Dimitriou, Stephan Schlickeiser, Hanieh Moradian, Sven Geissler, Michael Schmueck‐Henneresse, Manfred Gossen, Hans‐Dieter Volk
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Beyond SARS‐CoV2 vaccines, mRNA drugs are being explored to overcome today's greatest healthcare burdens, including cancer and cardiovascular disease. Synthetic mRNA triggers immune responses in transfected cells, which can be reduced by c
Externí odkaz:
https://doaj.org/article/bc87cdf8b17443f38594ddec9b4f61d5
Autor:
Dipthi Bachamanda Somesh, Kristin Klose, Janita A. Maring, Désirée Kunkel, Karsten Jürchott, Stephanie I. Protze, Oliver Klein, Grit Nebrich, Matthias Becker, Ulrike Krüger, Timo Z. Nazari-Shafti, Volkmar Falk, Andreas Kurtz, Manfred Gossen, Christof Stamm
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Background Direct cardiac reprogramming is currently being investigated for the generation of cells with a true cardiomyocyte (CM) phenotype. Based on the original approach of cardiac transcription factor-induced reprogramming of fibroblasts
Externí odkaz:
https://doaj.org/article/c371854fe11c4e7097810a43c278f286
Autor:
Katrin Radloff, Birgitt Gutbier, Charlotte Maeve Dunne, Hanieh Moradian, Marko Schwestka, Manfred Gossen, Katharina Ahrens, Laura Kneller, Yadong Wang, Akanksha Moga, Leonidas Gkionis, Oliver Keil, Volker Fehring, Daniel Tondera, Klaus Giese, Ansgar Santel, Jörg Kaufmann, Martin Witzenrath
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102068- (2023)
Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically modulate gene expression within ECs is of high therapeutic value in treating diseases such
Externí odkaz:
https://doaj.org/article/5eca547cc46b4d08ba4476f7d8468a32
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Autor:
Uirá Souto Melo, Jerome Jatzlau, Cesar A. Prada-Medina, Elisabetta Flex, Sunhild Hartmann, Salaheddine Ali, Robert Schöpflin, Laura Bernardini, Andrea Ciolfi, M-Hossein Moeinzadeh, Marius-Konstantin Klever, Aybuge Altay, Pedro Vallecillo-García, Giovanna Carpentieri, Massimo Delledonne, Melanie-Jasmin Ort, Marko Schwestka, Giovanni Battista Ferrero, Marco Tartaglia, Alfredo Brusco, Manfred Gossen, Dirk Strunk, Sven Geißler, Stefan Mundlos, Sigmar Stricker, Petra Knaus, Elisa Giorgio, Malte Spielmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players in driving ectopic bone formation. Identifying novel genes and pathways rel
Externí odkaz:
https://doaj.org/article/4848e7ed684e495f8ace27fcba8b8f77
Autor:
Lena Peter, Désirée Jacqueline Wendering, Stephan Schlickeiser, Henrike Hoffmann, Rebecca Noster, Dimitrios Laurin Wagner, Ghazaleh Zarrinrad, Sandra Münch, Samira Picht, Sarah Schulenberg, Hanieh Moradian, Mir-Farzin Mashreghi, Oliver Klein, Manfred Gossen, Toralf Roch, Nina Babel, Petra Reinke, Hans-Dieter Volk, Leila Amini, Michael Schmueck-Henneresse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 52-73 (2022)
Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that compromises their immune response to infections and vaccines. For this reason, SOT patients have a high risk of developing severe coronavirus disease 2019 (COVID-19) a
Externí odkaz:
https://doaj.org/article/9113c01efc2341409d18184065607cd5
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 854-869 (2022)
In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines. Robust expression levels, lack of
Externí odkaz:
https://doaj.org/article/33098f5b6d044b3a88560070716004b2
Autor:
Uirá Souto Melo, Jerome Jatzlau, Cesar A. Prada-Medina, Elisabetta Flex, Sunhild Hartmann, Salaheddine Ali, Robert Schöpflin, Laura Bernardini, Andrea Ciolfi, M-Hossein Moeinzadeh, Marius-Konstantin Klever, Aybuge Altay, Pedro Vallecillo-García, Giovanna Carpentieri, Massimo Delledonne, Melanie-Jasmin Ort, Marko Schwestka, Giovanni Battista Ferrero, Marco Tartaglia, Alfredo Brusco, Manfred Gossen, Dirk Strunk, Sven Geißler, Stefan Mundlos, Sigmar Stricker, Petra Knaus, Elisa Giorgio, Malte Spielmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/81fd3b11d7934ebcb13c04401024e74d