Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Manfred Braeter"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 54:977-986
Background Propiverine hydrochloride (P4) is an antimuscarinic drug used in overactive bladder syndrome. Methods Two studies were performed: one in 24 patients with open-angle glaucoma (OAG) treated with topical β-blockers, one in 24 patients with n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60f0045d982fbc12d5e8d9e07c2e6b0
https://doi.org/10.5414/cp202638
https://doi.org/10.5414/cp202638
Autor:
Christiane Modess, Stefan Oswald, Manfred Braeter, Danilo Wegner, Thomas Giessmann, K. May, Reinhard Oertel, Werner Siegmund
Publikováno v:
European Journal of Clinical Pharmacology. 64:1085-1092
The muscarine receptor antagonist propiverine in immediate release tablet form (IR) undergoes presystemic elimination mediated by CYP450 enzymes and intestinal efflux transporters. The aim of our study with propiverine IR and extended release (ER) wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3575cebc38d7a60b5e64b15ede7a7b85
https://doi.org/10.1007/s00228-008-0528-0
https://doi.org/10.1007/s00228-008-0528-0
Autor:
K. May, Reinhard Oertel, Manfred Braeter, Markus M. Lerch, Danilo Wegner, Werner Siegmund, Werner Weitschies, Ulrike Adam, Thomas Giessmann, Rolf Warzok, Kristin Westphal
Publikováno v:
The Journal of Clinical Pharmacology. 48:570-579
Propiverine extended release is expected to be better tolerated compared to immediate release tablets because of slower drug release and reduced formation of active metabolites in the colon. CYP3A4 and ABCC2, the major variables in pharmacokinetics o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec15720d6bc54bb477947cc3cbfab73
https://doi.org/10.1177/0091270008315314
https://doi.org/10.1177/0091270008315314
Autor:
Manfred Braeter, Martin C. Michel, Ursula Ravens, Gerhard Strugala, Birgit Eichhorn, Melinda Wuest
Publikováno v:
Pflugers Archiv, 456(2), 349-358. Springer Verlag
Urinary bladder function is known to mature during fetal and postnatal development, including changes in neurotransmitter regulation of detrusor contraction. However, only few experimental data are available about muscarinic receptor antagonist funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7efcb9f40ba8f1c7ce5c77cf24a5de
https://doi.org/10.1007/s00424-007-0407-z
https://doi.org/10.1007/s00424-007-0407-z
Autor:
Torsten Christ, Ursula Ravens, Pascal Champeroux, Melinda Wuest, Frank Donath, Erich Wettwer, Serge Richard, Manfred Braeter
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 376:431-440
Drugs that prolong the QT interval by blocking human ether-a-go-go (HERG) channels may enhance the risk of ventricular arrhythmia. The spasmolytic drug propiverine is widely used for the therapy of overactive bladder (OAB). Here, we have investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1741138f22a58d817e75995c61858a
https://doi.org/10.1007/s00210-007-0231-1
https://doi.org/10.1007/s00210-007-0231-1
Autor:
Manfred Braeter, Oliver W. Hakenberg, Nicole Hiller, Manfred P. Wirth, Ursula Ravens, Melinda Wuest
Publikováno v:
European Journal of Pharmacology. 565:180-189
Carbachol-induced detrusor contractions are mainly mediated via M 3 receptor subtype and depend not only on Ca 2+ release from the intracellular calcium stores but also on Ca 2+ influx via L-type Ca 2+ channels. The purpose of this study was to exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58089a1d2a709cb02dbf0b48dcd7586f
https://doi.org/10.1016/j.ejphar.2007.02.046
https://doi.org/10.1016/j.ejphar.2007.02.046
Publikováno v:
European Journal of Pharmacology. 524:145-148
In isolated detrusor strips, propiverine is known to be effective to decrease contractions elicited by electric field stimulation (EFS). Here we investigated whether the metabolites M-5, M-6 and M-14 of propiverine retain the pharmacological properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51d4d9f8353983b1d561bdd307e8f8e
https://doi.org/10.1016/j.ejphar.2005.09.040
https://doi.org/10.1016/j.ejphar.2005.09.040
Autor:
Ursula Ravens, Oliver W. Hakenberg, Manfred Braeter, Torsten Christ, Christian Schoeberl, Juliane Hecht, Melinda Wuest, Manfred P. Wirth
Publikováno v:
British Journal of Pharmacology. 145:608-619
Besides its antimuscarinic effects, propiverine may possess an additional mode of action. We compared the effects of propiverine, three of its metabolites (M-5, M-6, M-14) and atropine in human, pig and mouse urinary bladder preparations in order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c613078067be03f8012b5f4218bd381
https://doi.org/10.1038/sj.bjp.0706244
https://doi.org/10.1038/sj.bjp.0706244
Autor:
Ursula Ravens, Oliver W. Hakenberg, Eva-Maria Graf, Manfred Braeter, Melinda Wuest, Kathrin Morgenstern, Manfred P. Wirth
Publikováno v:
Journal of Urology. 173:2182-2189
We investigated whether the contractility of isolated human detrusor muscle, responsiveness to commonly used spasmolytic drugs, and expression of selected muscarinic and purinergic (P2X) receptor subtypes (M2, M3, P2X1 and P2X3) change with age.Tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c704d9e4ef046760824a7e1a8693d8d
https://doi.org/10.1097/01.ju.0000158126.53702.e4
https://doi.org/10.1097/01.ju.0000158126.53702.e4
Autor:
Ursula Ravens, Stefan Propping, Manfred P. Wirth, Manfred Braeter, Melinda Wuest, Marc-Oliver Grimm
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 381(4)
The muscarinic receptor antagonist propiverine used for therapy of overactive bladder undergoes first pass metabolism, leading to several active metabolites, which affect muscarinic receptors and L-type Ca2+ channels with different potencies. M-5, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce77ff630d803bf97efa6d7af04f13ae
https://pubmed.ncbi.nlm.nih.gov/20182702
https://pubmed.ncbi.nlm.nih.gov/20182702