Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Manfred Bohn"'
Autor:
Manfred Bohn, Dieter W Heermann
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14428 (2011)
One striking feature of chromatin organization is that chromosomes are compartmentalized into distinct territories during interphase, the degree of intermingling being much smaller than expected for linear chains. A growing body of evidence indicates
Externí odkaz:
https://doaj.org/article/0d633a69223f4ec8ae2ffff748195568
Autor:
Manfred Bohn, Dieter W Heermann
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12218 (2010)
Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple scales of length and time. Despite recent progress in understanding the folding motifs of chromatin, the higher-order structure still remains elusive. Various exp
Externí odkaz:
https://doaj.org/article/804639bbe6004c3cbfcbf5da0bb9b955
Autor:
Philipp M. Diesinger, Rainer Kaufmann, Dieter W. Heermann, Patrick Müller, Manuel Gunkel, Michael Hausmann, Manfred Bohn, Yanina Weiland, Alexa von Ketteler, Christoph Cremer, Paul Lemmer
Publikováno v:
Biophysical Journal. 99(5):1358-1367
A combined approach of 2D high-resolution localization light microscopy and statistical methods is presented to infer structural features and density fluctuations at the nuclear nanoscale. Hallmarks of nuclear nanostructure are found on the scale bel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41252af6745867e8adabb94daf168ea7
Publikováno v:
Macromolecules. 43:2564-2573
The ring structure of certain polymers in nature, like proteins and DNA indicates a benefit compared with the linear form. Transcriptional regulation in higher eukaryotes is maintained among others...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87e5f9e6850facea5ab765c492519271
https://doi.org/10.1021/ma902623u
https://doi.org/10.1021/ma902623u
Dermatopharmacology of ciclopirox nail lacquer topical solution 8% in the treatment of onychomycosis
Autor:
Manfred Bohn, Kraemer Karl Theodor
Publikováno v:
Journal of the American Academy of Dermatology. 43:S57-S69
Ciclopirox is a synthetic hydroxypyridone antifungal agent. In contrast to the azoles, glucuronidation is the main metabolic pathway of ciclopirox; therefore interactions with drugs metabolized via the cytochrome P450 system are unlikely Ciclopirox i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a3829021aa74fcf41dded885961782
https://doi.org/10.1067/mjd.2000.109072
https://doi.org/10.1067/mjd.2000.109072
Publikováno v:
Modeling, Simulation and Optimization of Complex Processes ISBN: 9783642257063
HPSC
HPSC
Human cells contain 46 chromosomes with a total length of about 5 cm beads-ona- string type of nucleosomal fibre, called chromatin. Packaging this into a nucleus of typically 5–20 μm diameter requires extensive compatification. This packaging cann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5af0c1e7d160c42ef20f7ae83811890c
https://doi.org/10.1007/978-3-642-25707-0_13
https://doi.org/10.1007/978-3-642-25707-0_13
Autor:
Pernette J. Verschure, Osdilly Giromus, Sandra Goetze, Erik M. M. Manders, Julio Mateos-Langerak, Dieter W. Heermann, Roel van Driel, Hinco J. Gierman, Manfred Bohn, Wim C. de Leeuw, Mireille H. G. Indemans
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3812-3817. National Academy of Sciences
Genome function in higher eukaryotes involves major changes in the spatial organization of the chromatin fiber. Nevertheless, our understanding of chromatin folding is remarkably limited. Polymer models have been used to describe chromatin folding. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffd16568c1e9edb1f2954eeb798cd8
https://dare.uva.nl/personal/pure/en/publications/spatially-confined-folding-of-chromatin-in-the-interphase-nucleus(a0d66949-ee6f-49fa-b467-76cbb71aee70).html
https://dare.uva.nl/personal/pure/en/publications/spatially-confined-folding-of-chromatin-in-the-interphase-nucleus(a0d66949-ee6f-49fa-b467-76cbb71aee70).html
Autor:
Dieter W. Heermann, Manfred Bohn
Monte Carlo simulations of coarse-grained polymers provide a useful tool to deepen the understanding of conformational and statistical properties of polymers both in physical as well as in biological systems. In this study we sample compact conformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7121a1ef65cb29963cc8b32b5cc6aff0
Publikováno v:
Physical Review E, 76(5). American Physical Society
While the structure of chromatin has been studied in great detail on length scales below 30 nm, amazingly little is known about the higher-order folding motifs of chromatin in interphase. Recent experiments give evidence that the folding may depend l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89caa8b2eead28853bcd25ae1622bf6b
Autor:
Dieter W. Heermann, Manfred Bohn
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14428 (2011)
PLoS ONE
PLoS ONE
One striking feature of chromatin organization is that chromosomes are compartmentalized into distinct territories during interphase, the degree of intermingling being much smaller than expected for linear chains. A growing body of evidence indicates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b7c6fcd98c1eb0c7ac52a374f76c83
https://doi.org/10.1371/journal.pone.0014428
https://doi.org/10.1371/journal.pone.0014428