Clinical Evaluation of Subcutaneous Lactate Measurement in Patients after Major Cardiac Surgery

Autor: Martin Ellmerer, Martin Haluzik, Jan Blaha, Jaromir Kremen, Stepan Svacina, Andreas Plasnik, Dimas Ikeoka, Manfred Bodenlenz, Lukas Schaupp, Johannes Plank, Thomas R. Pieber

Publikováno v: International Journal of Endocrinology, Vol 2009 (2009)

Minimally invasive techniques to access subcutaneous adipose tissue for glucose monitoring are successfully applied in type1 diabetic and critically ill patients. During critical illness, the addition of a lactate sensor might enhance prognosis and e

Externí odkaz: https://doaj.org/article/859a69000d3a4d1eb7a5266a741df2a1

Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging

Autor: Gitte Pommergaard Pedersen, Line Hollesen Schefe, Manfred Bodenlenz, Christian Janfelt, Frank Sinner, Stefan Eirefelt, André Huss Eriksson, Thomas Birngruber, Maja Lambert, Anne Mette Handler, Fredrik Johansson, Kim Troensegaard Nielsen, Nina Østergaard Knudsen

Publikováno v: Handler, A M, Eirefelt, S, Lambert, M, Johansson, F, Hollesen Schefe, L, Knudsen, N Ø, Bodenlenz, M, Birngruber, T, Sinner, F, Eriksson, A H, Pedersen, G P, Janfelt, C & Troensegaard Nielsen, K 2021, ' Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging ', Molecular Pharmaceutics, vol. 18, no. 8, pp. 3063-3072 . https://doi.org/10.1021/acs.molpharmaceut.1c00285

Traditionally, cutaneous drug delivery is studied by skin accumulation or skin permeation, while alternative techniques may enable the interactions between the drug and the skin to be studied in more detail. Time-resolved skin profiling for pharmacok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afaf40a0d690fd7ebd85237ac597828
https://curis.ku.dk/ws/files/336199777/MolecularPharmaceutics18_3063_3072_2021_preprint.pdf

Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution

Autor: Frank Sinner, Manfred Bodenlenz, Thomas Augustin, Bernd Tschapeller, Francois Rony, Beate Boulgaropoulos, Christina Gatschelhofer, Nathalie Wagner, Lisa Liebenberger, Christian Dragatin, Reingard Raml, Thomas R. Pieber, Khaled Benkali

Publikováno v: Pharmaceutical Research

Purpose To evaluate the kinetics of topically applied clobetasol-17-propionate (CP-17) in lesional and non-lesional psoriatic skin when released from a commercially available low-strength cream using in vivo dermal open-flow microperfusion (dOFM). Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89edf2f1d109403eb70942d6bfbcb20d
http://europepmc.org/articles/PMC4967091

Characterization of the Psoriasis-like Inflammation in the Imiquimod Rat Model using Dermal Open Flow Microperfusion

Autor: Manfred Bodenlenz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::733870a7e46ca86ad0b28c2670c65c7e
https://doi.org/10.26226/morressier.595a9c59d462b80296c9fdb1

Erratum to: Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence

Autor: Sam G. Raney, Thomas R. Pieber, Katrin I. Tiffner, Manfred Bodenlenz, Isadore Kanfer, Thomas Birngruber, Christian Dragatin, Denise Schimek, Gerd Schwagerle, Frank Sinner, Reingard Raml, Thomas Augustin

Publikováno v: Clinical Pharmacokinetics

Background The availability of generic topical dermatological drug products is constrained by the limited methods established to assess topical bioequivalence (BE). A novel cutaneous pharmacokinetic approach, dermal open-flow microperfusion (dOFM), c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8979dac7ffe7a8cec393267c83371aa
https://europepmc.org/articles/PMC6828129/