Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Manfred B, Lutz"'
Autor:
Mohammad Badr, Rhonda L. McFleder, Jingjing Wu, Susanne Knorr, James B. Koprich, Thomas Hünig, Jonathan M. Brotchie, Jens Volkmann, Manfred B. Lutz, Chi Wang Ip
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Regulatory CD4+CD25+FoxP3+ T cells (Treg) are a subgroup of T lymphocytes involved in maintaining immune balance. Disturbance of Treg number and impaired suppressive function of Treg correlate with Parkinson’s disease severity.
Externí odkaz:
https://doaj.org/article/ded71ba65a6c4640bc37adca0c1102e3
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Myeloid-derived suppressor cells (MDSC) represent major regulators of immune responses, which can control T cells via their inducible nitric oxide synthase (iNOS)- and arginase 1 (Arg1)-mediated effector functions. While GM-CSF is well documented to
Externí odkaz:
https://doaj.org/article/7c8f74f5f6264a91800627c3e2512c17
Autor:
Haroon Shaikh, Joern Pezoldt, Zeinab Mokhtari, Juan Gamboa Vargas, Duc-Dung Le, Josefina Peña Mosca, Estibaliz Arellano Viera, Michael A.G. Kern, Caroline Graf, Niklas Beyersdorf, Manfred B. Lutz, Angela Riedel, Maike Büttner-Herold, Alma Zernecke, Hermann Einsele, Antoine-Emmanuel Saliba, Burkhard Ludewig, Jochen Huehn, Andreas Beilhack
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Acute graft versus host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target
Externí odkaz:
https://doaj.org/article/611e9d7a43884ebd9ad1480c9f61f8b7
Autor:
Bernard Ong’ondo Osero, Zama Cele, Raphael Taiwo Aruleba, Rebeng A. Maine, Mumin Ozturk, Manfred B. Lutz, Frank Brombacher, Ramona Hurdayal
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
IL-4 and IL-13 cytokines have been associated with a non-healing phenotype in murine leishmaniasis in L. mexicana -infected BALB/c mice as demonstrated in IL-4−/−, IL-13−/− and IL-4Rα-/- global knockout mouse studies. However, it is unclear
Externí odkaz:
https://doaj.org/article/1e2395cad0bc46f6bdcf17a4c4c03927
Autor:
Anna Sophie Thomann, Theresa Schneider, Laura Cyran, Ina Nathalie Eckert, Andreas Kerstan, Manfred B. Lutz
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cell anergy is a common mechanism of T cell tolerance. However, although anergic T cells are retained for longer time periods in their hosts, they remain functionally passive. Here, we describe the induction of anergic CD4+ T cells in vivo by intra
Externí odkaz:
https://doaj.org/article/de46ae94dfcc43b88d36fb19c27beafa
Autor:
Ina N. Eckert, Eliana Ribechini, Katja J. Jarick, Sandra Strozniak, Sarah J. Potter, Andreas Beilhack, Manfred B. Lutz
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Myeloid-derived suppressor cells (MDSCs) represent a major population controlling T cell immune responses. However, little is known about their molecular requirements for homing and T cell interaction to mediate suppression. Here, we investigated the
Externí odkaz:
https://doaj.org/article/5ba9e7cf80b34ca79fd0e3525c67160a
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
BackgroundAlveolar echinococcosis (AE), caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis, is a chronic zoonosis associated with significant modulation of the host immune response. A role of regulatory T-cells (Tr
Externí odkaz:
https://doaj.org/article/7e5d76bc3f7a4bd398038db59ea732d0
Autor:
Leigh A. Kotzé, Carly Young, Vinzeigh N. Leukes, Vini John, Zhuo Fang, Gerhard Walzl, Manfred B. Lutz, Nelita du Plessis
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth. Ineffective innate and adaptive immune responses
Externí odkaz:
https://doaj.org/article/1a0e3d9e8311438990e96e6f9a8af54f
Autor:
Paloma Riquelme, Jan Haarer, Anja Kammler, Lisa Walter, Stefan Tomiuk, Norbert Ahrens, Anja K. Wege, Ivan Goecze, Daniel Zecher, Bernhard Banas, Rainer Spang, Fred Fändrich, Manfred B. Lutz, Birgit Sawitzki, Hans J. Schlitt, Jordi Ochando, Edward K. Geissler, James A. Hutchinson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs ma
Externí odkaz:
https://doaj.org/article/bde1072b3b4842efb0f1df25fc4a3f9e
Autor:
Eliana Ribechini, James A. Hutchinson, Sabine Hergovits, Marion Heuer, Jörg Lucas, Ulrike Schleicher, Ana-Laura Jordán Garrote, Sarah J. Potter, Paloma Riquelme, Heike Brackmann, Nora Müller, Hartmann Raifer, Ingolf Berberich, Magdalena Huber, Andreas Beilhack, Michael Lohoff, Christian Bogdan, Matthias Eyrich, Heike M. Hermanns, Edward K. Geissler, Manfred B. Lutz
Publikováno v:
Blood Advances, Vol 1, Iss 14, Pp 947-960 (2017)
Abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls proliferation and survival of myeloid cells including monocytes. Here, we describe a time-dependent licensing process driven by GM-CSF in murine Ly6Chigh and human CD14+ mon
Externí odkaz:
https://doaj.org/article/01939da1159e4606bd40390d8e10d0d3