Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Manfred, Konrad"'
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154702 (2016)
Choline kinase beta (CKβ) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. CKβ is important for normal mitochondrial function and muscle development as the lack of the ckβ gene in human and mice results in the develop
Externí odkaz:
https://doaj.org/article/be3801881c5d4c2dbe85777ad2721a77
Autor:
Andre G. Skirtach, Manfred Konrad, Anatolii Abalymov, Vsevolod S. Atkin, Bogdan Parakhonskiy, Laura A. E. Van Poelvoorde
Publikováno v:
ACS applied bio materials. 3(5)
Composite bioceramic and hydrogel-based containers harboring alkaline phosphatase are generated through encapsulation of this enzyme by its immobilization into CaCO3-based bioceramic materials in c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cf6b28adbcea5c5303deea862598e8
https://pubmed.ncbi.nlm.nih.gov/35025345
https://pubmed.ncbi.nlm.nih.gov/35025345
Autor:
Louis, Van der Meeren, Jie, Li, Manfred, Konrad, Andre G, Skirtach, Dmitry, Volodkin, Bogdan V, Parakhonskiy
Publikováno v:
Macromolecular bioscience. 20(7)
Encapsulation of enzymes allows to preserve their biological activities in various environmental conditions, such as exposure to elevated temperature or to proteases. This is particularly relevant for in vivo applications, where proteases represent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf49640e8f9470d991795c026ee37c4c
https://pubmed.ncbi.nlm.nih.gov/32484303
https://pubmed.ncbi.nlm.nih.gov/32484303
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12999 (2010)
BackgroundCholine kinase is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine, the major phospholipid in eukaryotic cell membranes. In humans, choline kinase exists as three isoforms (CKα1, α2, and β). Specific inhib
Externí odkaz:
https://doaj.org/article/95288dc810b84d8daa3a664c3698d074
Autor:
David Ban, Manfred Konrad, Marta G. Carneiro, Nazimuddin Khan, Donghan Lee, T. Michael Sabo, Pablo Trigo-Mouriño
Publikováno v:
Biomolecular NMR Assignments. 12:11-14
Human guanylate kinase (hGMPK) is a critical enzyme that, in addition to phosphorylating its physiological substrate (d)GMP, catalyzes the second phosphorylation step in the conversion of anti-viral and anti-cancer nucleoside analogs to their corresp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da992b4fd5ba236986e6d39ff80e59c6
https://doi.org/10.1007/s12104-017-9771-6
https://doi.org/10.1007/s12104-017-9771-6
Autor:
Marta G. Carneiro, Nazimuddin Khan, Levi J. Beverly, T.M. Sabo, William L. Dean, David Ban, Manfred Konrad, John O. Trent, Pablo Trigo-Mouriño, Parag P. Shah, Donghan Lee, Lynn DeLeeuw
Publikováno v:
J Biol Chem
Human guanylate kinase (hGMPK) is the only known enzyme responsible for cellular GDP production, making it essential for cellular viability and proliferation. Moreover, hGMPK has been assigned a critical role in metabolic activation of antiviral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543cd0aa8ce6d22bc91963cf5715c9f6
https://europepmc.org/articles/PMC6682748/
https://europepmc.org/articles/PMC6682748/
We investigated melting transitions in biological membranes in their native state that include their membrane proteins. These membranes originated from \textit{E. coli}, \textit{B. subtilis}, lung surfactant and nerve tissue from the spinal cord of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232ffbefb67c5730aae26959f77ef440
Autor:
Christos S. Karamitros, Manfred Konrad
Publikováno v:
ACS Chemical Biology
Immunogenicity is one of the most common complications occurring during therapy making use of protein drugs of nonhuman origin. A notable example of such a case is bacterial l-asparaginases (L-ASNases) used for the treatment of acute lymphoblastic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b98549978e6dd6a8df90d96f0791622
https://doi.org/10.1021/acschembio.6b00283
https://doi.org/10.1021/acschembio.6b00283
Autor:
Jie Li, Bogdan Parakhonskiy, Manfred Konrad, Dmitry Volodkin, Andre G. Skirtach, Louis Van der Meeren
Publikováno v:
Macromolecular Bioscience. 20:2000081
Encapsulation of enzymes allows to preserve their biological activities in various environmental conditions, such as exposure to elevated temperature or to proteases. This is particularly relevant for in vivo applications, where proteases represent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ae26a30dc62421cbd70d16ca6069dc
https://doi.org/10.1002/mabi.202000081
https://doi.org/10.1002/mabi.202000081
Autor:
Delphine C, Douillet, Benoît, Pinson, Johanna, Ceschin, Hans C, Hürlimann, Christelle, Saint-Marc, Damien, Laporte, Stéphane, Claverol, Manfred, Konrad, Marc, Bonneu, Bertrand, Daignan-Fornier
Publikováno v:
The Journal of biological chemistry. 294(3)
5-Aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR, or acadesine) is a precursor of the monophosphate derivative 5-amino-4-imidazole carboxamide ribonucleoside 5′-phosphate (ZMP), an intermediate in de novo purine biosynthesis. AICAR prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ace5c414032fc143f3f909e3a9bbe8f5
https://pubmed.ncbi.nlm.nih.gov/30478173
https://pubmed.ncbi.nlm.nih.gov/30478173