The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

Autor: Ashley L. Comes, Darina Czamara, Kristina Adorjan, Heike Anderson-Schmidt, Till F. M. Andlauer, Monika Budde, Katrin Gade, Maria Hake, Janos L. Kalman, Sergi Papiol, Daniela Reich-Erkelenz, Farah Klöhn-Saghatolislam, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Georg Juckel, Max Schmauß, Jörg Zimmermann, Jens Reimer, Eva Reininghaus, Ion-George Anghelescu, Carsten Konrad, Andreas Thiel, Christian Figge, Martin von Hagen, Manfred Koller, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Stephanie H. Witt, Sugirthan Sivalingam, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Jens Wiltfang, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Publikováno v: International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-12 (2020)

Abstract Background Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. Methods We explored the role of DNA methylation in response to recent s

Externí odkaz: https://doaj.org/article/d9a20649518a4c5f8f2c241edc22b781

The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders

Autor: Sebastian Stierl, Andreas Thiel, Fanny Senner, Volker Arolt, Ion-George Anghelescu, Manfred Koller, Eva C. Schulte, Markus M. Noethen, Janos L. Kalman, Daniela Reich-Erkelenz, Markus Jaeger, Here Folkerts, Urs Heilbronner, Bernhard T. Baune, Katrin Gade, Heike Anderson-Schmidt, Ashley L. Comes, Eva Z. Reininghaus, Kristina Adorjan, Georg Juckel, Maria Hake, Stephanie H. Witt, Harald Scherk, Farah Kloehn-Saghatolislam, Till F. M. Andlauer, Sabrina K. Schaupp, Jens Wiltfang, Franziska Degenhardt, Udo Dannlowski, Martin von Hagen, Max Schmauss, Monika Budde, Marcella Rietschel, Andreas J. Forstner, Moritz E. Wigand, Peter Falkai, Christian Figge, Thomas Becker, Carsten Konrad, Carsten Spitzer, Jens Reimer, Joerg Zimmermann, Sergi Papiol, Andreas J. Fallgatter, Detlef E. Dietrich, Vanessa Nieratschker, Thomas G. Schulze

Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019)
Translational Psychiatry 9(1), 210 (2019). doi:10.1038/s41398-019-0547-x
Translational Psychiatry

Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports a genome-wide polygenic score (GPS) for educational attainment (GPSEDU) can be used to explain variability in cognitive performa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b52c5668840b3b39b4ddea741f1c089
http://link.springer.com/article/10.1038/s41398-019-0547-x

An investigation of psychosis subgroups with prognostic validation and exploration of genetic underpinnings: the PsyCourse Study

Autor: Ida Sybille Haußleiter, Sabrina K. Schaupp, Nikola S. Mueller, Eva Z. Reininghaus, Joseph Kambeitz, Sophia Stegmaier, Anne Ruef, Andreas J. Forstner, Markus Jäger, Georg Juckel, Jörg Zimmermann, Jens Reimer, Here Folkerts, Stephanie H. Witt, Katrin Gade, Laura Flatau-Nagel, Alkomiet Hasan, Fabian U. Lang, Harald Scherk, Lana Kambeitz-Ilankovic, Dominic B. Dwyer, Kristina Adorjan, Carsten Konrad, Thomas Becker, Till F. M. Andlauer, Ivan Kondofersky, Volker Arolt, Sergi Papiol, Monika Budde, Farah Klöhn-Saghatolislam, Anna Gryaznova, Daniela Reich-Erkelenz, Markus Reitt, Martin von Hagen, Maria Hake, Janos Kalman, Vanessa Nieratschker, Bernhard T. Baune, Max Schmauß, Christian Figge, Tomoya Yoshida, Ashley L. Comes, Carsten Spitzer, Urs Heilbronner, Linda A. Antonucci, Fanny Senner, Moritz E. Wigand, Jens Wiltfang, Ion-George Anghelescu, Udo Dannlowski, Nikolaos Koutsouleris, Detlef E. Dietrich, Kim Bartholdi, Milena Meyers, Thomas G. Schulze, Barbara Emons, Markus M. Nöthen, Marcella Rietschel, Manfred Koller, Eva C. Schulte, Andreas Thiel, Andreas J. Fallgatter, Peter Falkai, Silke Quast, Heike Anderson-Schmidt, Franziska Degenhardt

Publikováno v: JAMA Psychiatry

IMPORTANCE: Identifying psychosis subgroups could improve clinical and research precision. Research has focused on symptom subgroups, but there is a need to consider a broader clinical spectrum, disentangle illness trajectories, and investigate genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58172914cc8da702cb90722b53a711e9
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/77096

Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study

Autor: Francis M. Mondimore, Farah Klohn-Sagatholislam, Jana Strohmaier, Jens Wiltfang, Jay Raymond DePaulo, Udo Dannlowski, Markus Jäger, Moritz E. Wigand, Ion Anghelescu, Michael Bauer, Louise Frisén, Ashley L. Comes, Carsten Spitzer, Claire Slaney, Janice M. Fullerton, Giovanni Severino, Janusz K. Rybakowski, Andreas J. Fallgatter, Maria Hake, Martin Alda, Peter R. Schofield, Susanne Bengesser, Nirmala Akula, Stefan Herms, Paul D. Shilling, Franziska Degenhardt, Mazda Adli, Armin Birner, Alexandre Dayer, Cristiana Cruceanu, Fanny Senner, Peter Falkai, Maria Del Zompo, Mark A. Frye, Christian Simhandl, Stéphane Jamain, Andrea Pfennig, Layla Kassem, Sébastien Gard, Heike Anderson-Schmidt, Marion Leboyer, Peter P. Zandi, Susan L. McElroy, Martin Schalling, Sebastian Stierl, Detlef E. Dietrich, Frank Bellivier, Palmiero Monteleone, Sybille Schulz, Caterina Chillotti, Volker Arolt, Michael McCarthy, Alfonso Tortorella, Andreas Thiel, Marcella Rietschel, Kristina Adorjan, Tatyana Shekhtman, Maria Grigoroiu-Serbanescu, Jean-Michel Aubry, Daniela Reich-Erkelenz, Laura Flatau, Markus Reitt, Harald Scherk, Here Folkerts, Julia Veeh, Joanna Hauser, Fernando S. Goes, Philip B. Mitchell, Gustavo Turecki, John R. Kelsoe, Thomas Stamm, Sophia Stegmaier, Georg Juckel, Markus M. Nöthen, Lina Martinsson, Bárbara Arias, Vanessa Nieratschker, Clara Brichant-Petitjean, Antonio Benabarre, Bernhard T. Baune, James B. Potash, Urs Heilbronner, Caroline M. Nievergelt, Raffaella Ardau, Mikael Landén, Pablo Cervantes, Pavla Stopkova, Adam Wright, Tomas Novak, Scott R. Clark, Manfred Koller, Gonzalo Laje, Katrin Gade, Andreas J. Forstner, Sarah Kittel-Schneider, Susan G. Leckband, Sebastian Kliwicki, Guy A. Rouleau, Kim Bartholdi, Martin von Hagen, Per Hoffmann, Eva C. Schulte, Alessio Squassina, Monika Budde, Thomas G. Schulze, Eduard Vieta, Liping Hou, Jörg Zimmermann, Barbara König, Stephan Ripke, Sarah K. Tighe, Jean-Pierre Kahn, Julie Garnham, Piotr M. Czerski, Janos Kalman, Anna Gryaznova, Francis J. McMahon, Mario Maj, Thomas Becker, Thomas Ethofer, Andreas Reif, Carsten Konrad, Mirko Manchia, Lena Backlund, Jens Reimer, Urban Ösby, Esther Jiménez, Abesh Kumar Bhattacharjee, Marina Mitjans, Sergi Papiol, Stephanie H. Witt, Sven Cichon, Bruno Etain, Till F. M. Andlauer, Joanna M. Biernacka, Max Schmauß, Christian Figge, Fabian U. Lang, N. Lackner, Eva Z. Reininghaus, Francesc Colom, Catharina Lavebratt, K Oliver Schubert

Publikováno v: Bipolar Disorders, Vol. 21, No 1 (2019) pp. 68-75
Bipolar Disorders

OBJECTIVES: Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beffbb5325db68f9961edb00d28ef682
https://doi.org/10.1111/bdi.12659

Cover Image, Volume 180B, Number 2, March 2019

Autor: Monika Budde, Heike Anderson‐Schmidt, Katrin Gade, Daniela Reich‐Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn‐Saghatolislam, Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Sabrina K. Schaupp, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion‐George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 180

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::978f495f2ad7986dc4ceb392bd9bab33
https://doi.org/10.1002/ajmg.b.32717