Endothelial EphB4 maintains vascular integrity and transport function in adult heart.

Autor: Luxán G; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Stewen J; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Díaz N; Regulatory Genomics Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Kato K; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Maney SK; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Aravamudhan A; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Berkenfeld F; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Nagelmann N; Department of Clinical Radiology, University Hospital Münster, Münster, Germany., Drexler HC; Bioanalytical Mass Spectrometry Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Zeuschner D; Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Faber C; Department of Clinical Radiology, University Hospital Münster, Münster, Germany., Schillers H; Institute for Physiology II, University of Münster, Münster, Germany., Hermann S; European Institute for Molecular Imaging, University of Münster, Münster, Germany., Wiseman J; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Vaquerizas JM; Regulatory Genomics Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Pitulescu ME; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Adams RH; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Faculty of Medicine, University of Münster, Münster, Germany.

Publikováno v: ELife [Elife] 2019 Nov 29; Vol. 8. Date of Electronic Publication: 2019 Nov 29.

Tumor Necrosis Factor-Mediated Survival of CD169 ⁺ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

Autor: Shinde PV; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Xu HC; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Maney SK; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Kloetgen A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.; Computational Biology of Infection Research, Helmholtz Center for Infection Research, Braunschweig, Germany., Namineni S; Institute of Virology, TU Munich, Munich, Germany.; Institute of Molecular Immunology, Technische Universität Munich and Helmholtz Zentrum Munich, Munich, Germany., Zhuang Y; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Honke N; Department of Rheumatology, Hiller Research Center Rheumatology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Shaabani N; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA., Bellora N; Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales (IPATEC), Universidad Nacional del Comahue-CONICET, Bariloche, Argentina., Doerrenberg M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany., Trilling M; Institute for Virology of the University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Pozdeev VI; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., van Rooijen N; Department of Cell Biology, Vrije University Medical Center, Amsterdam, Netherlands., Scheu S; Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Pfeffer K; Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Crocker PR; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Tanaka M; Laboratory of Immune Regulation, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Duggimpudi S; Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany., Knolle P; Institute of Molecular Immunology, Technische Universität Munich and Helmholtz Zentrum Munich, Munich, Germany., Heikenwalder M; Institute of Virology, TU Munich, Munich, Germany.; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ruland J; Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Center for Infection Research (DZIF), partner site Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany., Mak TW; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Brenner D; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.; Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark., Pandyra AA; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Hoell JI; Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany., Häussinger D; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Lang KS; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Lang PA; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany langp@uni-duesseldorf.de.

Publikováno v: Journal of virology [J Virol] 2018 Jan 17; Vol. 92 (3). Date of Electronic Publication: 2018 Jan 17 (Print Publication: 2018).

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Autor: Maney SK; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., McIlwain DR; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA., Polz R; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Pandyra AA; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Sundaram B; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Wolff D; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Ohishi K; Department of Pathology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan., Maretzky T; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA., Brooke MA; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK., Evers A; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA., Vasudevan AA; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Aghaeepour N; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA., Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany., Münk C; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Häussinger D; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Mak TW; Campell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada., Nolan GP; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA., Kelsell DP; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK., Blobel CP; Department of Pathology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Departments of Medicine and of Physiology, Biophysics and Systems Biology, Weill Medical College of Cornell University, New York, NY 10021, USA., Lang KS; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Lang PA; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. philipp.lang@med.uni-duesseldorf.de.

Publikováno v: Science signaling [Sci Signal] 2015 Nov 03; Vol. 8 (401), pp. ra109. Date of Electronic Publication: 2015 Nov 03.

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Autor: Khairnar V; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Duhan V; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Maney SK; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Honke N; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Shaabani N; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Pandyra AA; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Seifert M; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstrasse 173, Essen 45122, Germany., Pozdeev V; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Xu HC; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Sharma P; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Baldin F; Clinic for Primary Immunodeficiency, Medical Outpatient Unit and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel 4031, Switzerland., Marquardsen F; Clinic for Primary Immunodeficiency, Medical Outpatient Unit and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel 4031, Switzerland., Merches K; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Department of Physiology I, University of Tuebingen, Gmelinstrasse 5, Tuebingen 72076, Germany., Lang E; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Kirschning C; Institute of Medical Microbiology, Faculty of Medicine, University Hospital Essen, Hufelandstrasse 55, Essen 45122, Germany., Westendorf AM; Institute of Medical Microbiology, Faculty of Medicine, University Hospital Essen, Hufelandstrasse 55, Essen 45122, Germany., Häussinger D; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany., Lang F; Department of Physiology I, University of Tuebingen, Gmelinstrasse 5, Tuebingen 72076, Germany., Dittmer U; Institute of Virology, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Küppers R; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstrasse 173, Essen 45122, Germany., Recher M; Clinic for Primary Immunodeficiency, Medical Outpatient Unit and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel 4031, Switzerland., Hardt C; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Scheffrahn I; Clinic of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Beauchemin N; Rosalind and Morris Goodman Cancer Centre, Departments of Biochemistry, Medicine and Oncology, McIntyre Medical Science Building, Montreal, Quebec, Canada H3G 1Y6., Göthert JR; Department of Hematology, West German Cancer Center (WTZ), University Hospital Essen, Hufelandstrasse 55, Essen 45147, Germany., Singer BB; Institute of Anatomy, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany., Lang PA; 1] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany [2] Department of Molecular Medicine II, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany., Lang KS; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.

Publikováno v: Nature communications [Nat Commun] 2015 Feb 18; Vol. 6, pp. 6217. Date of Electronic Publication: 2015 Feb 18.

Tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether isolated from Njavara (Oryza sativa L. var. Njavara), induce apoptosis in multiple tumor cells by mitochondrial pathway.

Autor: Mohanlal S; Chemical Sciences and Technology Division, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, Industrial Estate P. O., Thiruvananthapuram, 695019, Kerala, India., Maney SK, Santhoshkumar TR, Jayalekshmy A

Publikováno v: Journal of natural medicines [J Nat Med] 2013 Jul; Vol. 67 (3), pp. 528-33. Date of Electronic Publication: 2012 Oct 09.