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Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis

Autor: Anderson, Amy E., Maney, Nicola J., Nair, Nisha, Lendrem, Dennis W., Skelton, Andrew J., Diboll, Julie, Brown, Philip M., Smith, Graham R., Carmody, Ruaidhrí J., Barton, Anne, Isaacs, John D., Pratt, Arthur G.

Publikováno v: Anderson, A E, Maney, N J, Nair, N, Lendrem, D W, Skelton, A J, Diboll, J, Brown, P M, Smith, G R, Carmody, R J, Barton, A, Isaacs, J D & Pratt, A G 2019, ' Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis ', Rheumatology (United Kingdom), vol. 58, no. 7, pp. 1250-1258 . https://doi.org/10.1093/rheumatology/kez003

Objectives. Dysregulated signal transduction and activator of transcription-3 (STAT3) signalling in CD4+ T cells has been proposed as an early pathophysiological event in RA. We sought further evidence for this observation, and to determine its clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::7e470bd26c98607cbea81e9dbe8af306
https://doi.org/10.1093/rheumatology/kez003

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Autor: Ridgley, Laura A., Anderson, Amy E., Maney, Nicola J., Naamane, Najib, Skelton, Andrew J., Lawson, Catherine A., Emery, Paul, Isaacs, John D., Carmody, Ruaidhrí J., Pratt, Arthur G.

Publikováno v: Frontiers in Immunology; 7/3/2019, p1-11, 11p

Dendritic cell maturation and survival are differentially regulated by TNF receptors 1 and 21

Autor: Maney, Nicola J., Reynolds, Gary, Krippner-Heidenreich, Anja, Hilkens, Catharien M.U.

The capacity of dendritic cells (DC) to regulate adaptive immunity is controlled by their maturation state and lifespan. Although TNF is a well-known maturation and survival factor for DC, the role of the two TNFR, TNFR1 and TNFR2, in mediating these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::569383e67e6543c62651a642de67b937
https://europepmc.org/articles/PMC4896387/

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