The regulation of dendritic cell maturation and survival by tumour necrosis factor receptors 1 and 2

Autor: Maney, Nicola Jayne

Dendritic cells (DC) are potent antigen presenting cells which have been implicated in a number of autoimmune diseases. Tumour necrosis factor (TNF) is a key mediator of inflammatory diseases such as rheumatoid arthritis (RA) and plays a central role

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658350

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming

Autor: Cooles, Faye, Tarn, Jessica, Lendrem, Dennis, Naamane, Najib, Lin, Chung Ma, Millar, Ben, Maney, Nicola, Anderson, Amy, Thalayasingam, Nishanthi, Diboll, Julie, Bondet, Vincent, Duffy, Darragh, Barnes, Michael, Smith, Graham, Ng, Sandra, Watson, David, Henkin, Rafael, Cope, Andrew, Reynard, Louise, Pratt, Arthur, Isaacs, John

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, In press, ⟨10.1136/annrheumdis-2022-222370⟩
Cooles, F A H, Tarn, J, Lendrem, D W, Naamane, N, Lin, C M A, Millar, B, Maney, N J, Anderson, A E, Thalayasingam, N, Diboll, J, Bondet, V, Duffy, D, Barnes, M R, Smith, G R, Ng, S, Watson, D, Henkin, R, Cope, A P, Reynard, L N, Pratt, A G & Isaacs, J D 2022, ' Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming ', Annals of the rheumatic diseases, vol. 81, no. 9, heartjnl-2022-222370, pp. 1214-1223 . https://doi.org/10.1136/annrheumdis-2022-222370
Ann Rheum Dis

ObjectivesAn interferon (IFN) gene signature (IGS) is present in approximately 50% of early, treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively impact initial response to treatment. We wished to validate this ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecfeba33e2085ceadcfd3a0dc4f6ae0
https://hal.science/hal-03699421/file/annrheumdis-2022-222370.full.pdf

Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis

Autor: Anderson, Amy E., Maney, Nicola J., Nair, Nisha, Lendrem, Dennis W., Skelton, Andrew J., Diboll, Julie, Brown, Philip M., Smith, Graham R., Carmody, Ruaidhrí J., Barton, Anne, Isaacs, John D., Pratt, Arthur G.

Publikováno v: Anderson, A E, Maney, N J, Nair, N, Lendrem, D W, Skelton, A J, Diboll, J, Brown, P M, Smith, G R, Carmody, R J, Barton, A, Isaacs, J D & Pratt, A G 2019, ' Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis ', Rheumatology (United Kingdom), vol. 58, no. 7, pp. 1250-1258 . https://doi.org/10.1093/rheumatology/kez003

Objectives. Dysregulated signal transduction and activator of transcription-3 (STAT3) signalling in CD4+ T cells has been proposed as an early pathophysiological event in RA. We sought further evidence for this observation, and to determine its clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::7e470bd26c98607cbea81e9dbe8af306
https://doi.org/10.1093/rheumatology/kez003

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Autor: Ridgley, Laura A., Anderson, Amy E., Maney, Nicola J., Naamane, Najib, Skelton, Andrew J., Lawson, Catherine A., Emery, Paul, Isaacs, John D., Carmody, Ruaidhrí J., Pratt, Arthur G.

Publikováno v: Frontiers in Immunology; 7/3/2019, p1-11, 11p

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