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Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications

Autor: Pinilla I, Maneu V, Campello L, Fernández-Sánchez L, Martínez-Gil N, Kutsyr O, Sánchez-Sáez X, Sánchez-Castillo C, Lax P, Cuenca N

Publikováno v: Antioxidants
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically heterogeneous diseases characterized by the progressive degeneration of the retina, ultimately leading to loss of visual function. Oxidative stress and inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::51f62d9f281cc7bec95241bab0eac3cd
https://pubmed.ncbi.nlm.nih.gov/35739983/

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Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation

Autor: Kutsyr O, Noailles A, Martinez-Gil N, Maestre-Carballa L, Martinez-Garcia M, Maneu V, Cuenca N, Lax P

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal degeneration, we assessed retinal function and morphology, inflammatory state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::efb88e26c188f91cd3eca5d4f5ab1c61
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8299

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Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration

Autor: Kutsyr O, Sánchez-Sáez X, Martínez-Gil N, de Juan E, Lax P, Maneu V, Cuenca N

Publikováno v: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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PURPOSE: Retinitis pigmentosa (RP) is a blinding neurodegenerative disease of the retina that can be affected by many factors. The present study aimed to analyze the effect of different environmental light intensities in rd10 mice retina. METHODS: C5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b378e063886fd1907065a7485d983d9a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441298/

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Interpretation of OCT and OCTA images from a histological approach: Clinical and experimental implications

Autor: Cuenca N, Ortuño-Lizarán I, Sánchez-Sáez X, Kutsyr O, Albertos-Arranz H, Fernández-Sánchez L, Martínez-Gil N, Noailles A, López-Garrido JA, López-Gálvez M, Lax P, Maneu V, Pinilla I

Publikováno v: PROG RETIN EYE RES
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal diseases, thanks to its resolution and its ability to inform of the retinal state in secon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::be472b1a0965320be44d6b6ecdc445bf
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6351

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New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10

Autor: Campello L, Kutsyr O, Noailles A, Michalska P, Fernández-Sánchez L, Martínez-Gil N, Ortuño-Lizarán I, Sánchez-Sáez X, de Juan E, Lax P, León R, García AG, Cuenca N, Maneu V

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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BACKGROUND/AIMS: It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::2d997cca8c6dd1a97b37c6765d818b9e
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6350

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Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms

Autor: Lax P, Ortuño-Lizarán I, Maneu V, Vidal-Sanz M, Cuenca N

Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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Melanopsin-containing retinal ganglion cells (mRGCs) represent a third class of retinal photoreceptors involved in regulating the pupillary light reflex and circadian photoentrainment, among other things. The functional integrity of the circadian sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::46730675d5de0e0c19472c4ca89ef9c8
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6352

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Cannabinoid-mediated retinal rescue correlates with improved circadian parameters in retinal dystrophic rats

Autor: Lax P, Kutsyr O, Esquiva G, Altavilla C, Maneu V, Cuenca N

Publikováno v: EXPERIMENTAL EYE RESEARCH
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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Ocular pathologies and blindness have been linked to circadian disorders. In previous studies, our group has demonstrated that retinitis pigmentosa is associated with degenerative changes in the melanopsin system and weaker circadian patterns. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::9bcc26b55f236a5bfaaed30f82248387
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6310

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The Absence of Toll-Like Receptor 4 Mildly Affects the Structure and Function in the Adult Mouse Retina

Autor: Noailles A, Kutsyr O, Maneu V, Ortuño-Lizarán I, Campello L, de Juan E, Gómez-Vicente V, Cuenca N, Lax P

Publikováno v: FRONTIERS IN CELLULAR NEUROSCIENCE
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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The innate immune Toll-like receptor (TLR) family plays essential roles in cell proliferation, survival and function of the central nervous system. However, the way in which TLRs contribute to the development and maintenance of proper retinal structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::f521f02787d92fe872d2c38ba8cc5d4b
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6354

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