Výsledky vyhledávání - "Maneth Gravell"

RNase inhibition of human immunodeficiency virus infection of H9 cells

Autor: Rebecca S. Hamilton, Richard J. Youle, Kuslima Shogen, Dianne L. Newton, You-Neng Wu, Stanislaw M. Mikulski, Maneth Gravell, Giuseppe D'Alessio

Publikováno v: Proceedings of the National Academy of Sciences. 91:6012-6016

Onconase and bovine seminal RNase, two members of the RNase A superfamily, inhibit human immunodeficiency virus type 1 replication in H9 leukemia cells 90-99.9% over a 4-day incubation at concentrations not toxic to uninfected H9 cells. Two other mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2942f734fa68a0e1e34d39daa92b7ce4
https://doi.org/10.1073/pnas.91.13.6012

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HLA-DR expression in macaque neuroendothelial cells in vitro and during SIV encephalitis

Autor: David Huddleston, Rebecca S. Hamilton, Gary Stone, Debra Riding In, Mark A. Beilke, Maneth Gravell, Clarence J. Gibbs, Wayne Nusbaum, Elaine K. Jordan, Gene Brashears

Publikováno v: Journal of Neuroimmunology. 33:129-143

HLA-DR expression in neuroendothelial cells (NEC) was studied during the course of SIV encephalitis in rhesus monkeys. HLA-DR determinants were detected on NEC in monkeys with SIV encephalitis, but not in control animals. In situ hybridization with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c32bfea05dc6d10bf0c9ef7de054a8a
https://doi.org/10.1016/0165-5728(91)90057-e

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Molecular Characterization of Simian Lentiviruses From East African Green Monkeys

Autor: Jonathan S. Allan, Maneth Gravell, William T. London, Philip R. Johnson, Anders Fomsgaard, Vanessa M. Hirsch

Publikováno v: Journal of Medical Primatology. 19:295-303

Asymptomatic infection with simian lentiviruses (also called simian immunodeficiency viruses, or SIV) is common among feral African green monkeys. To characterize the range of SIV genetic diversity among infected African green monkeys, we have determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fb0eae32064e56573c83a1b15ebe93e
https://doi.org/10.1111/j.1600-0684.1990.tb00436.x

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Transduction of motor neurons and muscle fibers by intramuscular injection of HIV-1-based vectors pseudotyped with select rabies virus glycoproteins

Autor: Maneth Gravell, Michael J. O'Donovan, Manfred Schubert, George Z. Mentis, Rebecca S. Hamilton, Neil A. Shneider

Publikováno v: Journal of neuroscience methods. 157(2)

For studies of motor neuron function or for therapeutic purposes, novel pseudotype HIV-1-based vectors were developed that are capable of expressing transgenes in motor neurons following injection into mouse hind limb muscles. To specifically target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc29cafdb182be7a7fe9cdf0b928c2f
https://pubmed.ncbi.nlm.nih.gov/16725205

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A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

Autor: Harish C. Pant, Manfred Schubert, Ya-Li Zheng, Niranjana D. Amin, Rebecca S. Hamilton, Wayne Albers, Maneth Gravell, Philip Grant, Sashi Kesavapany

The extracellular aggregation of amyloid beta (Abeta) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD). Cdk5 phosphorylates tau a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce101710e0e8f4f0d07d46ffee45790b
https://europepmc.org/articles/PMC544899/

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Comparison of Antibody Titers Determined by Hemagglutination Inhibition and Enzyme Immunoassay for JC Virus and BK Virus

Autor: R. S. Hamilton, Eugene O. Major, Maneth Gravell

A comparison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (HI) and enzyme immunoassay (EIA) with 114 human plasma samples. Antibody titers to JCV or BKV determined by HI were lower than those determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a6bf7a423f89b53b465fe14c99125a
https://europepmc.org/articles/PMC86031/

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Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys

Autor: D. Carleton Gajdusek, Clarence J. Gibbs, John R. Moffett, Chettemgere N S Venkateshan, Maneth Gravell, Rekha Narayanan, Aryan M A Namboodiri, Karen Blinder

Publikováno v: Journal of neurovirology. 2(6)

Quinolinate (QUIN), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that is thought to act through the NMD A receptor system, was localized in cultured peripheral blood monocytes/macrophages from SIV-infected monkeys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4615b97ef1b041d97f99b65586d32a7
https://pubmed.ncbi.nlm.nih.gov/8972426

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Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease

Autor: You-Neng Wu, Wojciech Ardelt, Shailendra K. Saxena, Maneth Gravell, Stanislaw M. Mikulski, Kuslima Shogen, Richard J. Youle

Publikováno v: The Journal of biological chemistry. 271(34)

Ribonucleases appear to have physiologic roles in host defense against cancer, viruses, and other parasites. Previously it was shown that select ribonucleases added to cells concurrently with virions blocked human immunodeficiency virus, type I (HIV-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8b736d7c5466c0bff7cc5c335b6356
https://pubmed.ncbi.nlm.nih.gov/8702832

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