Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Manesh Nautiyal"'
Autor:
Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Eveline Lescrinier, Jef Rozenski, Sergei V. Strelkov, Stephen D. Weeks, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 25, Iss 20, p 4751 (2020)
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazo
Externí odkaz:
https://doaj.org/article/1539736222b44698a5e71c211dda45c2
Autor:
Manesh Nautiyal, Bharat Gadakh, Steff De Graef, Luping Pang, Masroor Khan, Yi Xun, Jef Rozenski, Arthur Van Aerschot
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 180 (2019)
Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore new or existing targets/co
Externí odkaz:
https://doaj.org/article/ad75fea30d8442fb823e1cc75a1150a8
Autor:
Arthur Van Aerschot, Steff De Graef, Sergei V. Strelkov, Manesh Nautiyal, Jef Rozenski, Stephen D. Weeks, L. Pang, Wim M. De Borggraeve, Dries De Ruysscher
Publikováno v:
European Journal of Medicinal Chemistry. 174:252-264
The superfamily of adenylate-forming enzymes all share a common chemistry. They activate a carboxylate group, on a specific substrate, by catalyzing the formation of a high energy mixed phosphoanhydride-linked nucleoside intermediate. Members of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813f06cb5f8df483d30f678a84e36d3b
https://doi.org/10.1016/j.ejmech.2019.04.045
https://doi.org/10.1016/j.ejmech.2019.04.045
Autor:
Bao-Le Zhang, Stephen D. Weeks, Arthur Van Aerschot, Manesh Nautiyal, Steff De Graef, Sergei V. Strelkov, L. Pang, Eveline Lescrinier, Jef Rozenski, Bharat Gadakh
Publikováno v:
Molecules, Vol 25, Iss 4751, p 4751 (2020)
Molecules
Volume 25
Issue 20
'Molecules ', vol: 25, pages: 4751-1-4751-24 (2020)
Molecules
Volume 25
Issue 20
'Molecules ', vol: 25, pages: 4751-1-4751-24 (2020)
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fddd7749abe64e3120aeb6bdb0194a3
https://www.mdpi.com/1420-3049/25/20/4751
https://www.mdpi.com/1420-3049/25/20/4751
Autor:
Eveline Lescrinier, Dries De Ruysscher, Jef Rozenski, Charles-Alexandre Mattelaer, Sergei V. Strelkov, Arthur Van Aerschot, Stephen D. Weeks, Manesh Nautiyal, Steff De Graef, L. Pang
Publikováno v:
Bioorganicmedicinal chemistry. 28(15)
Antimicrobial resistance is considered as one of the major threats for the near future as the lack of effective treatments for various infections would cause more deaths than cancer by 2050. The development of new antibacterial drugs is considered as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a437580e7e380f3754a2b2ab4f86ba4
https://pubmed.ncbi.nlm.nih.gov/32631562
https://pubmed.ncbi.nlm.nih.gov/32631562
Autor:
Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Valentina Zorzini, Anastassios Economou, Sergei V. Strelkov, Arthur Van Aerschot, Stephen D. Weeks
Publikováno v:
ACS chemical biology. 15(2)
The pyrimidine-containing Trojan horse antibiotics albomycin and a recently discovered cytidine-containing microcin C analog target the class II seryl- and aspartyl-tRNA synthetases (serRS and aspRS), respectively. The active components of these comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b352969edef6bb86343c25556f068bec
https://pubmed.ncbi.nlm.nih.gov/31869198
https://pubmed.ncbi.nlm.nih.gov/31869198
Autor:
Yi Xun, Jef Rozenski, Arthur Van Aerschot, Bharat Gadakh, Manesh Nautiyal, L. Pang, Masroor Khan, Steff De Graef
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 180 (2019)
Antibiotics
Volume 8
Issue 4
Antibiotics
Volume 8
Issue 4
Emerging antibiotic resistance in pathogenic bacteria and reduction of compounds in the existing antibiotics discovery pipeline is the most critical concern for healthcare professionals. A potential solution aims to explore new or existing targets/co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d66d7fa721a9393ac321620b96e00e
https://www.mdpi.com/2079-6382/8/4/180
https://www.mdpi.com/2079-6382/8/4/180
Autor:
A. Van Aerschot, L. Pang, Sergei V. Strelkov, Stephen D. Weeks, Manesh Nautiyal, Bharat Gadakh, S. De Graef
Aminoacyl-tRNA synthetases (aaRSs) catalyse the ATP-dependent coupling of an amino acid to its cognate tRNA. Being vital for protein translation aaRSs are considered a promising target for the development of novel antimicrobial agents. 5'-O-(N-aminoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e526bdc75a4163d3763a8037a1fb80
https://lirias.kuleuven.be/handle/123456789/639961
https://lirias.kuleuven.be/handle/123456789/639961
Autor:
L. Pang, Steff De Graef, Bharat Gadakh, Manesh Nautiyal, Sergei V. Strelkov, Lieve Van Mellaert, Arthur Van Aerschot, Matheus Froeyen, Bao-Le Zhang, Stephen D. Weeks
Publikováno v:
European journal of medicinal chemistry. 148
Aminoacyl-tRNA synthetases (aaRSs) are enzymes that precisely attach an amino acid to its cognate tRNA. This process, which is essential for protein translation, is considered a viable target for the development of novel antimicrobial agents, provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306c57154c2998055c8d07c925cf7294
https://pubmed.ncbi.nlm.nih.gov/29477072
https://pubmed.ncbi.nlm.nih.gov/29477072
Autor:
Himanshu Sharma, Legesse Adane, Asit K. Chakraborti, Sahaj Pancholia, Manesh Nautiyal, Prahlad K. Meena, Pradeep S. Jadhavar, Dinesh Kumar
Publikováno v:
RSC Advances. 5:30819-30825
Simple, convenient, and green synthetic protocols have been developed for the one pot synthesis of 2,3-disubstituted quinazolin-4(3H)-ones and 2-styryl-3-substituted quinazolin-4(3H)-ones under catalyst and solvent free conditions. The multicomponent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2123013dec3bc6169dadc92bab78f01
https://doi.org/10.1039/c5ra03888j
https://doi.org/10.1039/c5ra03888j