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Akademický článek

In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast

Autor: Manel Ouji, Thibaud Reyser, Yoshiki Yamaryo-Botté, Michel Nguyen, David Rengel, Axelle Dutreuil, Marlène Marcellin, Odile Burlet-Schiltz, Jean-Michel Augereau, Michael K. Riscoe, Lucie Paloque, Cyrille Botté, Françoise Benoit-Vical

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 26, Iss , Pp 100565- (2024)

Emergence and spread of parasite resistance to artemisinins, the first-line antimalarial therapy, threaten the malaria eradication policy. To identify therapeutic targets to eliminate artemisinin-resistant parasites, the functioning of the apicoplast

Externí odkaz: https://doaj.org/article/b391844e85f845208759c016652562e2

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Akademický článek

Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites

Autor: Manel Ouji, Guillaume Barnoin, Álvaro Fernández Álvarez, Jean-Michel Augereau, Catherine Hemmert, Françoise Benoit-Vical, Heinz Gornitzka

Publikováno v: Molecules, Vol 25, Iss 12, p 2817 (2020)

The emergence of Plasmodium falciparum parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health. Therefore, the development of new antimalarial drugs or combi

Externí odkaz: https://doaj.org/article/c69d09a16117434d96bdd6baaccbf70d

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Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites

Autor: Manel Ouji, Tony Jimenez, Michel Nguyen, Céline Deraeve, Romain Mustière, Jean-Michel Augereau, Françoise Benoit-Vical

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 39, pp.127884. ⟨10.1016/j.bmcl.2021.127884⟩

International audience; Malaria is still considered as the major parasitic disease and the development of artemisinin resistance does not improve this alarming situation. Based on the recent identification of relevant malaria targets in the artemisin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41abaf98c1f240b14d8cd6d9df99d65a
https://pubmed.ncbi.nlm.nih.gov/33636304

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Identification of compounds active against quiescent artemisinin-resistant Plasmodium falciparum parasites via the quiescent-stage survival assay (QSA)

Autor: Sandie Menard, Manel Ouji, Michel Nguyen, Lucie Paloque, Thibaud Reyser, Françoise Benoit-Vical, Jean-Michel Augereau, Benoit Witkowski

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2020, 75 (10), pp.2826-2834. ⟨10.1093/jac/dkaa250⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, 75 (10), pp.2826-2834. ⟨10.1093/jac/dkaa250⟩

Background Quiescence is an unconventional mechanism of Plasmodium survival, mediating artemisinin resistance. This phenomenon increases the risk of clinical failures following artemisinin-based combination therapies (ACTs) by slowing parasite cleara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d00ca64d1f8b1d141200844be9fd630
https://hal.science/hal-02948398/document

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Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination

Autor: Lucie Paloque, Françoise Benoit-Vical, Jean-Michel Augereau, Manel Ouji

Publikováno v: Parasite
Parasite, EDP Sciences, 2018, 25, pp.24. ⟨10.1051/parasite/2018021⟩
Parasite, 2018, 25, pp.24. ⟨10.1051/parasite/2018021⟩
Parasite, Vol 25, p 24 (2018)

The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin derivative with a partner drug, in the treatment of uncomplicated malaria has largely been responsible for the significant reduction in malaria-related mortality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ffa78b4b994ba225fd758bd51014bc
https://hal.archives-ouvertes.fr/hal-01963526/file/parasite180024.pdf

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Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism

Autor: Françoise Benoit-Vical, Anne Robert, Jean-Michel Augereau, Manel Ouji, Joël Lelièvre, Lucie Paloque, Didier Menard, Tanila Ben Haddou, Frédéric Ariey, Bernard Meunier, Benoit Witkowski

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2018, 73 (2), pp.395-403. ⟨10.1093/jac/dkx412⟩

International audience; Background: Owing to the emergence of multiresistant Plasmodium falciparum parasites in Southeast Asia, along with the impressive decrease in the efficacy of the endoperoxide compound artemisinin and of artemisinin-based combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcffc96275d39a357cd070ca1b81f4e
https://pubmed.ncbi.nlm.nih.gov/29177421

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