Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Manel Cascalló"'
1
Akademický článek
Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors
Autor: Gabriel Capellá, Francisco X Real, Marta Gil-Martin, Rocio Garcia-Carbonero, Rafael Moreno, Ramon Alemany, Martí Farrera-Sal, Ramon Salazar, Teresa Macarulla, Jaime Martinez de Villarreal, Natalia del Pozo, Carmen Guillén-Ponce, Miriam Bazan-Peregrino, Rafael Álvarez, Ana Mato-Berciano, Emma Blasi, Carmen Blasco, Manel Cascallo, Maria C Riesco-Martinez, Helena Verdaguer, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Noemí Vidal
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral spread and facilitate chemotherapy and immune cells extravasation into
Externí odkaz: https://doaj.org/article/f20744c4524742ac8290f86ad68345d4
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3
Akademický článek
Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.
Autor: Beatriz Vera, Naiara Martínez-Vélez, Enric Xipell, Arlet Acanda de la Rocha, Ana Patiño-García, Javier Saez-Castresana, Marisol Gonzalez-Huarriz, Manel Cascallo, Ramón Alemany, Marta M Alonso
Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147211 (2016)
Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this stud
Externí odkaz: https://doaj.org/article/006f976004c545e6875fcc24e4b6ba37
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5
Data from Safety and Efficacy of VCN-01, an Oncolytic Adenovirus Combining Fiber HSG-Binding Domain Replacement with RGD and Hyaluronidase Expression
Autor: Ramon Alemany, Manel Cascalló, Miriam Bazan-Peregrino, Rafael Moreno, Juan J. Rojas, Marta Giménez-Alejandre, Alba Rodríguez-García
Purpose: Tumor targeting upon intravenous administration and subsequent intratumoral virus dissemination are key features to improve oncolytic adenovirus therapy. VCN-01 is a novel oncolytic adenovirus that combines selective replication conditional
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a35e965c7d65ec524f1380a698c1d0
https://doi.org/10.1158/1078-0432.c.6524102.v1
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8
Adenovirus-mediated gene transfer to tumor cells
Autor: Manel, Cascalló, Ramon, Alemany
Publikováno v: Methods in molecular biology (Clifton, N.J.). 246
Cell transduction in vitro is only the first step toward proving that a genetherapy vector can be useful to treat tumors. However, tumor targeting in vivo is now the milestone for gene therapy to succeed against disseminated cancer. Therefore, most v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43c5e6ce84dd485afa3eee2bdc96e36f
https://pubmed.ncbi.nlm.nih.gov/14970588
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9
Ras-dependent oncolysis with an adenovirus VAI mutant
Autor: Manel, Cascalló, Gabriel, Capellà, Adela, Mazo, Ramon, Alemany
Publikováno v: Cancer research. 63(17)
Adenovirus synthesize proteins that interact with oncogene and tumor suppressor gene products to set the cell for virus replication. Mutant viruses defective in these functions replicate selectively in cancer cells and represent new tools to treat ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cccc041ed5dc8de204b8b7f5b264b6aa
https://pubmed.ncbi.nlm.nih.gov/14500393
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