Zobrazeno 1 - 10
of 1 110
pro vyhledávání: '"Manel, Esteller"'
Autor:
Sandhya Malla, Kanchan Kumari, Carlos A. García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T. T. Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem
Externí odkaz:
https://doaj.org/article/2d6f847ecfc84532b688deb0fc0250d8
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-8 (2024)
ABSTRACTThe identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology. One of
Externí odkaz:
https://doaj.org/article/4ea947f99ba944dcb9cfb48246e9d20d
Autor:
Laura Lorenzo-Sanz, Marta Lopez-Cerda, Victoria da Silva-Diz, Marta H. Artés, Sandra Llop, Rosa M. Penin, Josep Oriol Bermejo, Eva Gonzalez-Suarez, Manel Esteller, Francesc Viñals, Enrique Espinosa, Marc Oliva, Josep M. Piulats, Juan Martin-Liberal, Purificación Muñoz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients remain unresponsive or develop resistance. Here, we show that, during
Externí odkaz:
https://doaj.org/article/6c15c4009def405287d24b7b6ae51b70
Autor:
Joan Jiménez-Balado, Isabel Fernández-Pérez, Cristina Gallego-Fábrega, Uxue Lazcano, Carolina Soriano-Tárraga, Marta Vallverdú-Prats, Marina Mola-Caminal, Lucía Rey-Álvarez, Adrià Macias-Gómez, Antoni Suárez-Pérez, Eva Giralt-Steinhauer, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Ángel Ois, Manel Esteller, Jaume Roquer, Israel Fernández-Cadenas, Jordi Jiménez-Conde
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background and aims Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals that may be attributed to genetics and epigenetics, including
Externí odkaz:
https://doaj.org/article/3f0b1b34c1ca432b9a498408bb37c80e
Autor:
Roshana Thambyrajah, Maria Maqueda, Muhammad Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Recent findings suggest that Hematopoietic Stem Cells (HSC) and progenitors arise simultaneously and independently of each other already in the embryonic aorta-gonad mesonephros region, but it is still unknown how their different features ar
Externí odkaz:
https://doaj.org/article/e2c4801c11ca4edbbdc98a6129f4d110
Autor:
Roshana Thambyrajah, Maria Maqueda, Wen Hao Neo, Kathleen Imbach, Yolanda Guillén, Daniela Grases, Zaki Fadlullah, Stefano Gambera, Francesca Matteini, Xiaonan Wang, Fernando J. Calero-Nieto, Manel Esteller, Maria Carolina Florian, Eduard Porta, Rui Benedito, Berthold Göttgens, Georges Lacaud, Lluis Espinosa, Anna Bigas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic clusters (IAHC) along with hematopoietic progenitors (HPC). The signal
Externí odkaz:
https://doaj.org/article/89ff244b2ed24e0cb8b752459be716ea
Autor:
Alberto Ayllon-Hermida, Marc Nicolau-Fernandez, Ane M. Larrinaga, Iris Aparici-Herraiz, Elisabet Tintó-Font, Oriol Llorà-Batlle, Agnes Orban, María Fernanda Yasnot, Mariona Graupera, Manel Esteller, Jean Popovici, Alfred Cortés, Hernando A. del Portillo, Carmen Fernandez-Becerra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Recent studies indicate that human spleen contains over 95% of the total parasite biomass during chronic asymptomatic infections caused by Plasmodium vivax. Previous studies have demonstrated that extracellular vesicles (EVs) secreted from infected r
Externí odkaz:
https://doaj.org/article/4c0c66b50a03457bb1b958779ad6f4d4
Autor:
Pere Llinàs-Arias, Miquel Ensenyat-Méndez, Javier I. J. Orozco, Sandra Íñiguez-Muñoz, Betsy Valdez, Chuan Wang, Anja Mezger, Eunkyoung Choi, Yan Zhou Tran, Liqun Yao, Franziska Bonath, Remi-André Olsen, Mattias Ormestad, Manel Esteller, Mathieu Lupien, Diego M. Marzese
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Objectives Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Unlike other breast cancer subtypes, the scarcity of specific therapies and greater frequencies of distant metastase
Externí odkaz:
https://doaj.org/article/ae6de6960e06403498b0edcc6089e71b
Autor:
Pere Llinàs-Arias, Miquel Ensenyat-Mendez, Sandra Íñiguez-Muñoz, Javier I. J. Orozco, Betsy Valdez, Matthew P. Salomon, Chikako Matsuba, Maria Solivellas-Pieras, Andrés F. Bedoya-López, Borja Sesé, Anja Mezger, Mattias Ormestad, Fernando Unzueta, Siri H. Strand, Alexander D. Boiko, E Shelley Hwang, Javier Cortés, Maggie L. DiNome, Manel Esteller, Mathieu Lupien, Diego M. Marzese
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (M
Externí odkaz:
https://doaj.org/article/b71cb755354f404e9aa916bdd4c51c9e
Autor:
María Gallardo-Gómez, Mar Rodríguez-Girondo, Núria Planell, Sebastian Moran, Luis Bujanda, Ane Etxart, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Manel Esteller, Joaquín Cubiella, David Gómez-Cabrero, Loretta De Chiara
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. A blood test may imp
Externí odkaz:
https://doaj.org/article/30aa5504516a4b318ec2757d888d1389