Výsledky vyhledávání - "Maneesh R Pingle"

Akademický článek

A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus.

Autor: Sanchita Das, Mark S Rundell, Aashiq H Mirza, Maneesh R Pingle, Kristi Shigyo, Aura R Garrison, Jason Paragas, Scott K Smith, Victoria A Olson, Davise H Larone, Eric D Spitzer, Francis Barany, Linnie M Golightly

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138484 (2015)

CDC designated category A infectious agents pose a major risk to national security and require special action for public health preparedness. They include viruses that cause viral hemorrhagic fever (VHF) syndrome as well as variola virus, the agent o

Externí odkaz: https://doaj.org/article/637abd023bcc47b6a5f64bb0e9ac9439

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Abstract B43: Reversible linkage of two distinct small molecule inhibitors of MYC generates a more potent and selective dimeric inhibitor that is active in cancer cell lines over-expressing MYC

Autor: Francis Barany, Yue Peng, Douglas S. Werner, Suzanne Russo, Lee D. Arnold, Earl W. May, Jutta Wanner, Darlene Romashko, Stuart Thomson, Donald E. Bergstrom, Kenneth W. Foreman, Ryan Schulz, Maneesh R Pingle

Publikováno v: Molecular Cancer Research. 13:B43-B43

Up to 70% of all human cancers have deregulated or elevated levels of MYC, making MYC a high profile cancer drug target. The disordered structure of the MYC protein has made identifying small molecule inhibitors of this target very challenging, howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa59aa2a9f7b3df0374c1440ed252477
https://doi.org/10.1158/1557-3125.myc15-b43

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Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Autor: Earl W. May, Douglas S. Werner, Francis Barany, Stuart Thomson, Yue Peng, Ryan Schulz, Kenneth W. Foreman, Lee D. Arnold, Donald E. Bergstrom, Darlene Romashko, Suzanne Russo, Maneesh R Pingle, Jutta Wanner

Publikováno v: PLoS ONE
Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications
PLoS ONE, Vol 10, Iss 4, p e0121793 (2015)

We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules.We synthesized two directed libraries of monomers, each comprised of a ligan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d8836f56302ebec21c1ca2b44180a7
https://doi.org/10.1371/journal.pone.0121793

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