Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maneesh Gujrati"'
Autor:
Scott M. Welford, Zheng-Rong Lu, Rebecca Schur, Maneesh Gujrati, Eli E. Bar, Raffaella Spina, Jun Lu, Junran Zhang, Vinay Pasupuleti, Yuji Seo, Bradley M. Wright, Adina Brett-Morris
Supplementary table and figures 1-3. Table 1: combined list of screen data identifying 10 genes that commonly sensitize cells to radiation when knocked down. S1: Western blot confirming knockdown of SAT1. S2: Expression of SAT1 in control and shSAT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90da0dc0de212e9e5c9791811a629fd8
https://doi.org/10.1158/0008-5472.22404219
https://doi.org/10.1158/0008-5472.22404219
Autor:
Zheng-Rong Lu, Anthony S. Malamas, Amita M. Vaidya, Margaret A. Mack, Maneesh Gujrati, Dayton Snyder
Publikováno v:
Advanced Healthcare Materials. 5:2882-2895
RNAi-mediated knockdown of oncogenes associated with drug resistance can potentially enhance the efficacy of chemotherapy. Here, we have designed and developed targeted dual pH-sensitive lipid-siRNA self-assembly nanoparticles, RGD-PEG(HZ)-ECO/siRNA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f930ecbb0ec12883f28b5aaa3cf33f
https://doi.org/10.1002/adhm.201600677
https://doi.org/10.1002/adhm.201600677
Publikováno v:
Molecular Pharmaceutics. 13:2497-2506
Stabilization of hypoxia inducible factor 1α (HIF-1α), a biomarker of hypoxia, in hypoxic tumors mediates a variety of downstream genes promoting tumor angiogenesis and cancer cell survival as well as invasion, and compromising therapeutic outcome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f2b8306908a52a332cc0195f6d82a1
https://doi.org/10.1021/acs.molpharmaceut.6b00227
https://doi.org/10.1021/acs.molpharmaceut.6b00227
Autor:
Hiroshi Maeno, Maneesh Gujrati, Krzysztof Palczewski, Tadao Maeda, Akiko Maeda, Zheng-Rong Lu, Da Sun, Rebecca M. Schur
Publikováno v:
Macromolecular Bioscience. 15:1663-1672
Development of safe and effective gene delivery systems is essential in treating ocular genetic disorders. A hybrid nonviral system composed of a multifunctional lipid ECO and a G4 nanoglobule was designed for efficient gene delivery into RPE cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c096ad990411cdc7b749181fe30f7a
https://doi.org/10.1002/mabi.201500192
https://doi.org/10.1002/mabi.201500192
Publikováno v:
Cancer Research. 75:2316-2325
Metastatic breast cancer is the second leading cause of cancer-related deaths among women. Triple-negative breast cancer (TNBC) is a highly aggressive subcategory of breast cancer and currently lacks well-defined molecular targets for effective targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fcacc1239d05989178edcb41a4a4cd
https://doi.org/10.1158/0008-5472.can-14-3485
https://doi.org/10.1158/0008-5472.can-14-3485
Autor:
Adina Brett-Morris, Vinay Pasupuleti, Junran Zhang, Bradley M. Wright, Maneesh Gujrati, Raffaella Spina, Scott M. Welford, Zheng-Rong Lu, Eli E. Bar, Jun Lu, Rebecca M. Schur, Yuji Seo
Publikováno v:
Cancer Research. 74:6925-6934
Glioblastoma multiforme (GBM) is the most common and severe form of brain cancer. The median survival time of patients is approximately 12 months due to poor responses to surgery and chemoradiation. To understand the mechanisms involved in radioresis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbae46e1657fc094a8c816ff52502194
https://doi.org/10.1158/0008-5472.can-14-1249
https://doi.org/10.1158/0008-5472.can-14-1249
Publikováno v:
Bioconjugate chemistry. 27(1)
RNA interference (RNAi) represents a powerful modality for human disease therapy that can regulate gene expression signature using small interfering RNA (siRNA). Successful delivery of siRNA into the cytoplasm of target cells is imperative for effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776207a6864ed063d7acf45b6e60cece
https://pubmed.ncbi.nlm.nih.gov/26629982
https://pubmed.ncbi.nlm.nih.gov/26629982
Autor:
Da, Sun, Hiroshi, Maeno, Maneesh, Gujrati, Rebecca, Schur, Akiko, Maeda, Tadao, Maeda, Krzysztof, Palczewski, Zheng-Rong, Lu
Publikováno v:
Macromolecular bioscience. 15(12)
Gene therapy is a promising approach to treat genetic diseases. Development of gene delivery systems with high efficiency and low toxicity is a high priority in clinical application of gene therapy. In this work, we designed and evaluated a hybrid no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1c61654f99703fcc01cd933f043c553
https://pubmed.ncbi.nlm.nih.gov/26271011
https://pubmed.ncbi.nlm.nih.gov/26271011
Autor:
Jennifer E. Adair, Jahangir Ahmed, Ghassan Alusi, Doron Amit, Scott J. Antonia, Dominick L. Auci, David A. August, Rutger K. Balvers, Lajos Baranyi, Brian C. Beard, Sebastian Brennig, Elizabeth K. Broussard, Paul D. Bryson, Andrew P. Byrnes, Denise L. Cecil, Tim Chan, Charlie Comins, Christiaan R. de Vries, Robert S. DiPaola, Clemens M.F. Dirven, Mary L. Disis, Boro Dropulic, Heather Embree, Michael W. Epperly, Juan Fueyo, Toshiyoshi Fujiwara, Hua Fung, Emmanuel Gabriel, Vidya Ganapath, Stanton L. Gerson, Steven Gill, Michal Gilon, Joe Goldufsky, Candelaria Gomez-Manzano, Jennifer Rubin Grandis, Joel S. Greenberger, John W. Greiner, Maneesh Gujrati, James L. Gulley, Amin Hajitou, Kevin J. Harrington, Arash Hatefi, Loree C. Heller, Richard Heller, Akseli Hemminki, Otto Hemminki, Ronald B. Herberman, Daniel Herendeen, Abraham Hochberg, James W. Hodge, Gregory E. Holt, Ying Huang, Insoo Hyun, Hong Jiang, Shunsuke Kagawa, Zahra Karjoo, Howard Kaufman, Chien-Chih Ke, Hans-Peter Kiem, Jonathan Kimmelman, Sarah R. Klein, Shinji Kuroda, Seong Young Kwon, Nico Lachmann, Hermann Lage, Martine L.M. Lamfers, Edmund C. Lattime, Nicholas R. Lemoine, Jonathan Lewis, John B. Liao, Steven K. Libutti, Yuan Lin, Ren-Shyan Liu, Zheng-Rong Lu, Ravi A. Madan, Imad Matouk, Alan Melcher, Andrew D. Miller, Jung-Joon Min, Thomas Moritz, James J. Mulé, Atsushi Natsume, Nastasia Nianiaris, Michael I. Nishimura, Claudia Palena, Hardev Pandha, Jessica Pastoriza, Mary C. Pinder-Schenck, Sujan Piya, Elizabeth Poplin, John A. Puskas, Thomas Quinn, Ankit Rao, Jane S. Reese, Kate Relph, Juan J. Rojas, Yvonne Saenger, Jeffrey Schlom, Kevin Shannon, Shawna A. Shirley, Guy R. Simpson, Shanthi Sivendran, Vladimir Slepushkin, Sirirurg Songsivilai, Neil Steven, Sufi Mary Thomas, Steve H. Thorne, Kwong-Yok Tsang, Takashi Tsujiuchi, Toshihiko Wakabayashi, Pin Wang, Xinxin Wang, Yaohe Wang, Robert E. Weiss, Edward White, Yohsuke Yagawa, Teerapong Yata, Ming Yuan, Ziqiang Yuan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9859ecd7a8906dc1395cd68c9b25af0d
https://doi.org/10.1016/b978-0-12-394295-1.00046-9
https://doi.org/10.1016/b978-0-12-394295-1.00046-9
Autor:
Maneesh Gujrati, Zheng-Rong Lu
RNA interference is a promising therapeutic modality to treat various cancers by specifically silencing the expression of cancer-related genes. Effective gene silencing requires specific delivery of small interfering RNA (siRNA) into target tissue an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9ceeb68049f8b82ade7a6005badfd2
https://doi.org/10.1016/b978-0-12-394295-1.00004-4
https://doi.org/10.1016/b978-0-12-394295-1.00004-4