Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Mandy Menzel"'
Autor:
Sofia Malm Tillgren, Juan José Nieto-Fontarigo, Samuel Cerps, Sangeetha Ramu, Mandy Menzel, Irma Mahmutovic Persson, Anja Meissner, Hamid Akbarshahi, Lena Uller
Publikováno v:
Journal of Inflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections. In in vivo mouse mod
Externí odkaz:
https://doaj.org/article/52f5eb48e6b44e03b8521176e6f1d753
Autor:
Mandy Menzel, Hamid Akbarshahi, Irma Mahmutovic Persson, Cecilia Andersson, Manoj Puthia, Lena Uller
Publikováno v:
Journal of Innate Immunity, Pp 1-10 (2021)
Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling is also involved in early activation of IFNβ, which
Externí odkaz:
https://doaj.org/article/79a98467b84a43ebb08acdc717b89b4f
Autor:
Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller, Cecilia K. Andersson
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in t
Externí odkaz:
https://doaj.org/article/abc116dee2964053bb80f7192e788dae
Autor:
Juan José Nieto-Fontarigo, Sofia Tillgren, Samuel Cerps, Asger Sverrild, Morten Hvidtfeldt, Sangeetha Ramu, Mandy Menzel, Adam Frederik Sander, Celeste Porsbjerg, Lena Uller
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundBoth anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cell
Externí odkaz:
https://doaj.org/article/5623b3cb3e854c208eade12876062e25
Autor:
Sangeetha Ramu, Jenny Calvén, Charalambos Michaeloudes, Mandy Menzel, Hamid Akbarshahi, Kian Fan Chung, Lena Uller
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Background Asthma exacerbations are commonly associated with rhinovirus (RV) infection. Interleukin-33 (IL-33) plays an important role during exacerbation by enhancing Type 2 inflammation. Recently we showed that RV infects bronchial smooth muscle ce
Externí odkaz:
https://doaj.org/article/ed0bcaf926eb448ea152c94b0c9fd60b
Autor:
Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi, Lena Uller
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also increase Th2-type cyto
Externí odkaz:
https://doaj.org/article/425beb14ae7746b0933ce43fab573f3f
Autor:
Mandy Menzel, Sangeetha Ramu, Jenny Calvén, Beata Olejnicka, Asger Sverrild, Celeste Porsbjerg, Ellen Tufvesson, Leif Bjermer, Hamid Akbarshahi, Lena Uller
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
COPD and asthma exacerbations are commonly triggered by rhinovirus infection. Potentially promoting exacerbations, impaired anti-viral signaling and attenuated viral clearance have been observed in diseased bronchial epithelium. Oxidative stress is a
Externí odkaz:
https://doaj.org/article/b66dcf06e27540a091d84d2a7e57fc42
Autor:
Mandy Menzel, Hamid Akbarshahi, Irma Mahmutovic Persson, Manoj Puthia, Leif Bjermer, Lena Uller
Publikováno v:
ERJ Open Research, Vol 3, Iss 4 (2017)
Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been imp
Externí odkaz:
https://doaj.org/article/b9aee0db483c4192adb08a0bea1b5043
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e42654 (2012)
Acute lung injury (ALI) is an important cause of mortality in critically ill patients. Acute pancreatitis (AP) is one of the risk factors for developing this syndrome. Among the inflammatory cells, macrophages have a key role in determining the sever
Externí odkaz:
https://doaj.org/article/fd808c38bcec4e1dbb2303e9fd5f1599
Autor:
Christian Woehlk, Sangeetha Ramu, Asger Sverrild, Juan José Nieto-Fontarigo, Sara Vázquez-Mera, Samuel Cerps, Alexis Pulga, Louise Munkholm Andreasson, Lise Lotte Eriksen, Nanna Dyhre-Petersen, Mandy Menzel, Ditte K. Klein, Susanne Hansen, Lena Uller, Celeste Porsbjerg
Publikováno v:
Am J Respir Crit Care Med
RATIONALE: Allergic asthma is linked to impaired bronchial epithelial secretion of IFNs, which may be causally linked to the increased risk of viral exacerbations. We have previously shown that allergen immunotherapy (AIT) effectively reduces asthma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f443babb0b8a170f92c4c29dfdf2bef
https://doi.org/10.1164/rccm.202209-1708oc
https://doi.org/10.1164/rccm.202209-1708oc