Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

Autor: Katy Billot, Mandy M. Smith, Rose Pitstick, Jagesh V. Shah, Kate Zhang, George A. Carlson, Laurent Meijer, Hervé Husson, Laurie A. Smith, Oxana Ibraghimov-Beskrovnaya, Monica Lane, Nikolay O. Bukanov, Steven R. Ledbetter, Ryan J. Russo, Sarah Moreno, David R. Beier, Mikhail Sergeev

Publikováno v: Human Molecular Genetics

Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation of fluid-filled kidney cysts and progression to end-stage renal disease. A mechanistic understanding of cystogenesis is crucial for the development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73419f470c354fca553c1926c6b7b4fa
https://doi.org/10.1093/hmg/ddw093

Identification of Factors Regulating Poly(A) Tail Synthesis and Maturation

Autor: Mandy M. Smith, David A. Mangus, Allan Jacobson, Jennifer M. McSweeney

Publikováno v: Molecular and Cellular Biology. 24:4196-4206

Posttranscriptional maturation of the 3' end of eukaryotic pre-mRNAs occurs as a three-step pathway involving site-specific cleavage, polymerization of a poly(A) tail, and trimming of the newly synthesized tail to its mature length. While most of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bdbae18318e728e62c7a4129b3f4e8
https://doi.org/10.1128/mcb.24.10.4196-4206.2004

Glomerulopathy in the KK.Cg-Ay/J Mouse Reflects the Pathology of Diabetic Nephropathy

Autor: Mandy M. Smith, Steven R. Ledbetter, Cynthia Arbeeny, John Lydon, William Weber, Lucy Phillips, Stefan Wawersik, Stephen J. O'Brien, Colleen Maloney, Hong Ling

Publikováno v: Journal of Diabetes Research, Vol 2013 (2013)
Journal of Diabetes Research

The KK.Cg-A (y) /J (KK-A (y) ) mouse strain is a previously described model of type 2 diabetes with renal impairment. In the present study, female KK-A (y) mice received an elevated fat content diet (24% of calories), and a cohort was uninephrectomiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ad957be06ade526c2c448044443901
https://doaj.org/article/f3db8fd35b12472690d08ded295794ac

Quality standards for the management of alcohol-related liver disease: consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology ARLD special interest group.

Autor: Parker R; Leeds Liver Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK richardparker@nhs.net.; Leeds Institute of Medical Research at St James's University Hospital, University of Leeds, Leeds, UK., Allison M; Cambridge Liver Unit, Addenbrooke's Hospital, Cambridge, UK., Anderson S; Angus Integrated Drug and Alcohol Recovery Service (AIDARS), Ninewells Hospital and Medical School, Dundee, UK., Aspinall R; Gastroenterology & Hepatology, Portsmouth Hospitals NHS Trust, Portsmouth, UK., Bardell S; Birmingham Liver Services Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Bains V; Liver Transplant Unit, King's College Hospital NHS Foundation Trust, London, UK., Buchanan R; Faculty of Medicine, University of Southampton, Southampton, UK., Corless L; Department of Gastroenterology, Hepatology and Endoscopy, Hull University Teaching Hospitals NHS Trust, Hull, UK., Davidson I; NHS Fife Addiction Services, NHS Fife, Kirkcaldy, UK., Dundas P; Peter Brunt Centre, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK., Fernandez J; Alcohol and Drug Liaison, Royal Free London NHS Foundation Trust, London, UK., Forrest E; Dept of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK., Forster E; Leeds Liver Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Freshwater D; Birmingham Liver Services Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Gailer R; Islington Primary Care Federation, London, UK., Goldin R; Department of Digestive Diseases, Department of Medicine, Imperial College London, London, UK., Hebditch V; British Liver Trust, Ringwood, UK., Hood S; Digestive Diseases Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Jones A; Pharmacy, Barts and The London NHS Trust, London, UK., Lavers V; Independent researcher, Plymouth, UK., Lindsay D; Alcohol Care Team, East Lancashire Hospitals NHS Trust, Blackburn, UK., Maurice J; Gastroenterology and hepatology, North Bristol NHS Trust, Westbury on Trym, UK., McDonagh J; Birmingham Liver Services Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Morgan S; Hampstead Group Practice, London, UK., Nurun T; Department of Gastroenterology, Hepatology and Endoscopy, Hull University Teaching Hospitals NHS Trust, Hull, UK., Oldroyd C; Cambridge Liver Unit, Addenbrooke's Hospital, Cambridge, UK., Oxley E; St Martins Practice, Leeds, UK., Pannifex S; Hepatology, St George's Healthcare NHS Trust, London, UK., Parsons G; Hepatology, Plymouth Hospitals NHS Trust, Plymouth, UK., Phillips T; Faculty of Health Sciences, University of Hull, Hull, UK., Rainford N; Liver Transplant Unit, King's College Hospital NHS Foundation Trust, London, UK., Rajoriya N; Birmingham Liver Services Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Richardson P; Gastroenterology and Hepatology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK., Ryan J; Sheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London, UK., Sayer J; Gastroenterology, Doncaster and Bassetlaw Hospitals NHS Foundation Trust, Doncaster, UK., Smith M; Alcohol care team, Southport and Ormskirk Hospital NHS Trust, Southport, UK., Srivastava A; Gastroenterology and hepatology, North Bristol NHS Trust, Westbury on Trym, UK., Stennett E; Gastroenterology, Guy's and St Thomas' Hospitals NHS Trust, London, UK., Towey J; Birmingham Liver Services Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Vaziri R; Humankind, Durham, UK., Webzell I; Liver Transplant Unit, King's College Hospital NHS Foundation Trust, London, UK., Wellstead A; Gastroenterology, University Hospitals Dorset NHS Foundation Trust, Poole, UK., Dhanda A; Faculty of health, University of Plymouth, Plymouth, UK., Masson S; Liver unit, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.

Publikováno v: BMJ open gastroenterology [BMJ Open Gastroenterol] 2023 Oct; Vol. 10 (1).

Protective socks for people with diabetes: a systematic review and narrative analysis.

Autor: Otter SJ; School of Rehabilitation & Occupation Studies, AUT University, North Shore Campus, Private Bag 92006, Auckland, 1142 New Zealand., Rome K; School of Rehabilitation & Occupation Studies, AUT University, North Shore Campus, Private Bag 92006, Auckland, 1142 New Zealand., Ihaka B; School of Rehabilitation & Occupation Studies, AUT University, North Shore Campus, Private Bag 92006, Auckland, 1142 New Zealand., South A; School of Rehabilitation & Occupation Studies, AUT University, North Shore Campus, Private Bag 92006, Auckland, 1142 New Zealand., Smith M; Fashion Design, School of Art & Design, AUT University, WW Building, 9 Mount Street, 1010 Private Bag 92006, Auckland, 1142 New Zealand., Gupta A; Textile and Design Laboratory, AUT University, WW Building, 9 Mount Street, 1010 Private Bag 92006, Auckland, 1142 New Zealand., Joseph F; Textile and Design Laboratory, AUT University, WW Building, 9 Mount Street, 1010 Private Bag 92006, Auckland, 1142 New Zealand., Heslop P; Textile and Design Laboratory, AUT University, WW Building, 9 Mount Street, 1010 Private Bag 92006, Auckland, 1142 New Zealand.

Publikováno v: Journal of foot and ankle research [J Foot Ankle Res] 2015 Mar 27; Vol. 8, pp. 9. Date of Electronic Publication: 2015 Mar 27 (Print Publication: 2015).