Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mandy L. McCracken"'
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volum
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volum
Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal model
Publikováno v:
Alcoholism: Clinical and Experimental Research. 37:2002-2010
Although ethanol (EtOH) is a prevalently used drug, the sites and mechanisms of action by which it produces its intoxicating effects are not thoroughly understood. One widely accepted idea is that EtOH acts at protein targets in the body. Among the s
Autor:
Mandy L. McCracken, Giorgio Gorini, Lindsay M. McCracken, R. Dayne Mayfield, James R. Trudell, R. Adron Harris
Publikováno v:
Frontiers in Molecular Neuroscience
Glycine receptors (GlyRs) mediate inhibitory neurotransmission and are targets for alcohols and anesthetics in brain. GlyR transmembrane (TM) domains contain critical residues for alcohol/anesthetic action: amino acid A288 in TM3 forms crosslinks wit
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:600-606
Alcohols and inhaled anesthetics enhance the function of GABA(A) receptors containing α, β, and γ subunits. Molecular analysis has focused on the role of the α subunits; however, there is evidence that the β subunits may also be important. The g
Autor:
Irene Oh, R. A. Harris, Mandy L. McCracken, Cecilia M. Borghese, M. S. Fanselow, Edmond I. Eger, David F. Werner, J. M. Sonner, Neil L. Harrison, Sangeetha Iyer, F. Jia, Vinuta Rau, A. Swihart, Gregg E. Homanics
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:134-144
The mechanism by which the inhaled anesthetic isoflurane produces amnesia and immobility is not understood. Isoflurane modulates GABA(A) receptors (GABA(A)-Rs) in a manner that makes them plausible targets. We asked whether GABA(A)-R α2 subunits con
Drugs of abuse represent a spectrum of chemically diverse compounds that are used via various routes of drug administration depending on the drug and its preparation. Although the exact molecular mechanisms by which these agents act to produce their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa79f42fe87a143daddba19a3435842
https://doi.org/10.1093/oxfordhb/9780199381678.013.010
https://doi.org/10.1093/oxfordhb/9780199381678.013.010
Autor:
A. Swihart, Gregg E. Homanics, Cecilia M. Borghese, C. R. Geil, David F. Werner, Sangeetha Iyer, Mandy L. McCracken, Jillian M. Benavidez, Neil L. Harrison, R. A. Harris, Elizabeth A. Osterndorff-Kahanek, Yuri A. Blednov
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 336(1)
GABA type A receptors (GABA A -Rs) are potential targets of ethanol. However, there are multiple subtypes of this receptor, and, thus far, individual subunits have not been definitively linked with specific ethanol behavioral actions. Interestingly,