Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Kelsey B. Bennion, Danya Liu, Abdelhameed S. Dawood, Megan M. Wyatt, Katie L. Alexander, Mohamed S. Abdel-Hakeem, Chrystal M. Paulos, Mandy L. Ford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The regulatory circuits dictating CD8+ T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report that tumor-infiltrating antigen-specific PD-1+ TCF-1− CD8+ T cells express the immunosupp
Externí odkaz:
https://doaj.org/article/ac5c51a14c4148dcaf211da0aa6ca675
Autor:
Jerome C. Anyalebechi, Yini Sun, Carolyn Davis, Maylene E. Wagener, Zhe Liang, Eileen M. Burd, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionA hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered on memory T cells during sepsis. We recently showed that treatment with
Externí odkaz:
https://doaj.org/article/429754ade8b144558594280f7c10d7ec
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionChronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell dysregulation within the adaptive immune system that has yet to be fully characterize
Externí odkaz:
https://doaj.org/article/373c77ea86584b28ad0dc557309905b3
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionCostimulation blockade targeting the CD28 pathway provides improved long-term renal allograft survival compared to calcineurin inhibitors but may be limited as CTLA-4-Ig (abatacept, belatacept) blocks both CD28 costimulation and CTLA-4 co
Externí odkaz:
https://doaj.org/article/6008c15a83eb49fe9b3460d521d029c6
Autor:
Nathan J. Klingensmith, Katherine T. Fay, David A. Swift, Julia M.R. Bazzano, John D. Lyons, Ching-wen Chen, Mei Meng, Kimberly M. Ramonell, Zhe Liang, Eileen M. Burd, Charles A. Parkos, Mandy L. Ford, Craig M. Coopersmith
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Expression of the tight junction–associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A –/– mice have increased gut permeability, yet parad
Externí odkaz:
https://doaj.org/article/fbfc530dda6d4b10a3967d7271e7af69
Autor:
Wenxiao Zhang, Jerome C. Anyalebechi, Kimberly M. Ramonell, Ching-wen Chen, Jianfeng Xie, Zhe Liang, Deena B. Chihade, Shunsuke Otani, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cancer are 10 ti
Externí odkaz:
https://doaj.org/article/e3b4a1216da947ec9e12320f24aaca42
Autor:
Yini Sun, Jerome C. Anyalebechi, He Sun, Tetsuya Yumoto, Ming Xue, Danya Liu, Zhe Liang, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating seps
Externí odkaz:
https://doaj.org/article/bf61aeac8d834d7fb9df755708167ceb
Autor:
Kristen N. Morrow, Zhe Liang, Ming Xue, Deena B. Chihade, Yini Sun, Ching-wen Chen, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102093- (2021)
Summary: Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to
Externí odkaz:
https://doaj.org/article/524248f651ff43ee98c877f6217ef49e
Autor:
Clara R. Farley, Anna B. Morris, Marvi Tariq, Kelsey B. Bennion, Sayalee Potdar, Ragini Kudchadkar, Michael C. Lowe, Mandy L. Ford
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
In the setting of cancer, T cells upregulate coinhibitory molecules that attenuate TCR signaling and lead to the loss of proliferative capacity and effector function. Checkpoint inhibitors currently in clinical use have dramatically improved mortalit
Externí odkaz:
https://doaj.org/article/f591a64e71054e5e8edf9829dfcf3161
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells
Externí odkaz:
https://doaj.org/article/1a5aef8a6d3e40728c42ca16369a7239