Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Autor: Nicholas A Kennedy, Graham A Heap, Harry D Green, Benjamin Hamilton, Claire Bewshea, Gareth J Walker, Amanda Thomas, Rachel Nice, Mandy H Perry, Sonia Bouri, Neil Chanchlani, Neel M Heerasing, Peter Hendy, Simeng Lin, Daniel R Gaya, J R Fraser Cummings, Christian P Selinger, Charlie W Lees, Ailsa L Hart, Miles Parkes, Shaji Sebastian, John C Mansfield, Peter M Irving, James Lindsay, Richard K Russell, Timothy J McDonald, Dermot McGovern, James R Goodhand, Tariq Ahmad, Vinod Patel, Zia Mazhar, Rebecca Saich, Ben Colleypriest, Tony C Tham, Tariq H Iqbal, Vishal Kaushik, Senthil Murugesan, Salil Singh, Sean Weaver, Cathryn Preston, Assad Butt, Melissa Smith, Dharamveer Basude, Amanda Beale, Sarah Langlands, Natalie Direkze, Franco Torrente, Juan De La Revella Negro, Chris Ewen MacDonald, Stephen M Evans, Anton V J Gunasekera, Alka Thakur, David Elphick, Achuth Shenoy, Chuka U Nwokolo, Anjan Dhar, Andrew T Cole, Anurag Agrawal, Stephen Bridger, Julie Doherty, Sheldon C Cooper, Shanika de Silva, Craig Mowat, Phillip Mayhead, Charlie Lees, Gareth Jones, James W Hart, Lisa Gervais, Paul Dunckley, Tariq Mahmood, Paul J R Banim, Sunil Sonwalkar, Deb Ghosh, Rosemary H Phillips, Amer Azaz, Richard Shenderey, Lawrence Armstrong, Claire Bell, Radhakrishnan Hariraj, Helen Matthews, Hasnain Jafferbhoy, Veena Zamvar, John S De Caestecker, Anne Willmott, Richard Miller, Palani Sathish Babu, Christos Tzivinikos, Stuart L Bloom, Guy Chung-Faye, Nicholas M Croft, John ME Fell, Marcus Harbord, Ailsa Hart, Ben Hope, James O Lindsay, Joel E Mawdsley, Alistair McNair, Kevin J Monahan, Charles D Murray, Timothy Orchard, Thankam Paul, Richard Pollok, Neil Shah, Matt W Johnson, Anita Modi, Kasamu Dawa Kabiru, B K Baburajan, Bim Bhaduri, Andrew Adebayo Fagbemi, Scott Levison, Jimmy K Limdi, Gill Watts, Stephen Foley, Arvind Ramadas, George MacFaul, John Mansfield, Leonie Grellier, Mary-Anne Morris, Mark Tremelling, Chris Hawkey, Sian Kirkham, Charles PJ Charlton, Astor Rodrigues, Alison Simmons, Stephen J Lewis, Jonathon Snook, Mark Tighe, Patrick M Goggin, Aminda N De Silva, Simon Lal, Mark S Smith, Simon Panter, Suranga Dharmisari, Martyn Carter, David Watts, Zahid Mahmood, Bruce McLain, Sandip Sen, Anna J Pigott, David Hobday, Emma Wesley, Richard Johnston, Cathryn Edwards, John Beckly, Deven Vani, Subramaniam Ramakrishnan, Rakesh Chaudhary, Nigel J Trudgill, Rachel Cooney, Andy Bell, Neeraj Prasad, John N Gordon, Matthew J Brookes, Andy Li, Stephen Gore

Publikováno v: The Lancet Gastroenterology & Hepatology. 4:341-353

BACKGROUND: Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cf9cdaaf826d8961db6241a4505d59
https://doi.org/10.1016/s2468-1253(19)30012-3

P118 Positivity thresholds of total infliximab and adalimumab anti-drug antibody assays and impact in clinical practice

Autor: Neil Chanchlani, Claire Gordon, Tariq Ahmad, Simeng Lin, Timothy J. McDonald, James R Goodhand, Rachel Nice, Nicholas A. Kennedy, Desmond Chee, Mandy H Perry, Benjamin Hamilton, Harry D Green, Claire Bewshea

Publikováno v: Posters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d6f987dd2a26d92929e758839ea1815
https://doi.org/10.1136/gutjnl-2020-bsgcampus.193

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

Autor: Petra J. M. Elders, Ana Viñuela, Roderick C. Slieker, Søren Brunak, Anitra D.M. Koopman, Torben Hansen, Femke Rutters, Martin Ridderstråle, Trynke Hoekstra, Andrea Mari, Bernd Jablonka, Ewan R. Pearson, Oluf Pedersen, Jurek Adamski, Tarja Kokkola, Giel Nijpels, Morgan Obura, Markku Laakso, Tue H. Hansen, Anubha Mahajan, Mandy H Perry, Leen M 't Hart, Hartmut Ruetten, Robert W. Koivula, Giuseppe N. Giordano, Azra Kurbasic, Jochen M. Schwenk, Emmanouil T. Dermitzakis, Mark I. McCarthy, Ian M Forgie, Timothy J. McDonald, Harriet Teare, Mark Walker, Federico De Masi, Alison Heggie, Paul W. Franks, Joline W.J. Beulens, Imre Pavo

Publikováno v: PLoS ONE
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, Hart, L M T, Rutters, F & for the IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, 15(11). PUBLIC LIBRARY SCIENCE
Obura, M, Beulens, J W J, Nijpels, G, Elders, P & IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11 November, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, 15(11 November):e0242360. Public Library of Science
PLoS ONE, 15(11):e0242360. Public Library of Science
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, de Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, Hart, L M T & Rutters, F 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLOS ONE, vol. 15, no. 11 November, e0242360 . https://doi.org/10.1371/journal.pone.0242360
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, 't Hart, L M, Rutters, F & IMI-DIRECT consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLOS ONE, vol. 15, no. 11, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, Vol 15, Iss 11, p e0242360 (2020)
IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11, e0242360, pp. e0242360 . https://doi.org/10.1371/journal.pone.0242360

Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0eb744952c11d1cf500b80544acb7a9
https://pubmed.ncbi.nlm.nih.gov/33253307

EDTA improves stability of whole blood C-peptide and insulin to over 24 hours at room temperature.

Autor: Timothy J McDonald, Mandy H Perry, Roy W A Peake, Nicola J Pullan, John O'Connor, Beverley M Shields, Beatrice A Knight, Andrew T Hattersley

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42084 (2012)

IntroductionC-peptide and insulin measurements in blood provide useful information regarding endogenous insulin secretion. Conflicting evidence on sample stability and handling procedures continue to limit the widespread clinical use of these tests.

Externí odkaz: https://doaj.org/article/8f95a3fc35aa459da00b865c69b7cac0

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Autor: Azra Kurbasic, Femke Rutters, Markku Laakso, Joline W.J. Beulens, Caroline Brorsson, Mark Walker, Tarja Kokkola, Emmanouil T. Dermitzakis, Gary Frost, Andrew T. Hattersley, Hartmut Ruetten, Søren Brunak, Simone P. Rauh, Federico De Masi, Ramneek Gupta, Imre Pavo, Christopher J. Groves, Jerzy Adamski, Andrea Tura, Bernd Jablonka, Alison Heggie, Tue H. Hansen, Ana Viñuela, Martin Ridderstråle, Andrea Mari, Jane Kaye, Henrik Vestergaard, Robert W. Koivula, Kristine H. Allin, Harriet Teare, Michelle Hudson, Thomas E. White, Jochen M. Schwenk, Mark I. McCarthy, Maritta Siloaho, Mandy H Perry, Ewan R. Pearson, Oluf Pedersen, Ian M Forgie, Timothy J. McDonald, Soren Brage, Anubha Mahajan, E. Louise Thomas, Paul W. Franks, Anitra D.M. Koopman, Philippe Froguel, Torben Hansen, Jimmy D. Bell, Giuseppe N. Giordano, Adem Y. Dawed

Publikováno v: Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S R, Brorsson, C A, Dawed, A Y, de Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S R, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & IMI DIRECT Consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S, Brorsson, C A, Dawed, A Y, De Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & IMI-DIRECT consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes : descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Diabetologia
Diabetologia, Vol. 62, No 9 (2019) pp. 1601-1615
Diabetologia, 62(9), 1601-1615. Springer Verlag
Diabetologia 62, 1601-1615 (2019)
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S, Brorsson, C A, Dawed, A Y, De Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & the IMI-DIRECT consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1

Aims/hypothesis Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 and 48 months of follow-up)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fc5bd3c22959b53a248befc4dd035d
https://research.vumc.nl/en/publications/5fde05e6-dbb5-4b2a-b5e2-07f7e0521b01