Výsledky vyhledávání - "Mandy Garnett"

Supplementary Figure and Movie Legends from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Autor: Steven Grant, Robert Z. Orlowski, Paul Dent, Dustin G. Larsen, Justin D. Richey, Gary L. Simmons, Florence Su, Daniella M. Schwartz, Mandy Garnett, Lora B. Kramer, Li Wang, Jennifer Myers, Xin-Yan Pei, Yun Dai, Shuang Chen

PDF file - 85K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b95c930bd4607e2d664f2c8f6c7e08
https://doi.org/10.1158/0008-5472.22395365

Zobrazit plný text záznamu

Supplementary Figure 2 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

PDF file - 140K, FP/obatoclax down-regulates Bcl-xL, but not Bcl-2, which plays a partial role in this regimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5b7a35837c00f7327a90838e024f7d
https://doi.org/10.1158/0008-5472.22395371

Zobrazit plný text záznamu

Supplementary Methods from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

PDF file - 108K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f8211d59cca7077480689266c9c4ab
https://doi.org/10.1158/0008-5472.22395362.v1

Zobrazit plný text záznamu

Supplementary Video 4 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

MOV file - 3MB, Video for the mice receiving both flavopiridol and obatolcax (day 120 after tumor cell injection via tail vein)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff609d4fdc6cb684c95ac668627eec1
https://doi.org/10.1158/0008-5472.22395350.v1

Zobrazit plný text záznamu

Supplementary Figure 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

PDF file - 104K, FP/obatoclax induces dose-dependent mitochondrial injury and cell death in MM cells, accompanied by down-regulation of Mcl-1 protein and mRNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8c586b81a1419cf2b0e104dbc01bfc
https://doi.org/10.1158/0008-5472.22395374.v1

Zobrazit plný text záznamu

Supplementary Video 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

MOV file - 2.5MB, Video for the mice receiving vehicle (day 80 after tumor cell injection via tail vein)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e4c6dbf2aa83639efc35ea222dc30f
https://doi.org/10.1158/0008-5472.22395359.v1

Zobrazit plný text záznamu

Supplementary Video 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

MOV file - 9.5MB, Video for the mice receiving obatolcax (day 120 after tumor cell injection via tail vein)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfc392acb5e803a2a295929374be450
https://doi.org/10.1158/0008-5472.22395353

Zobrazit plný text záznamu

CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Autor: Gary Lee Simmons, Paul Dent, Lora Kramer, Dustin Larsen, Justin D. Richey, Xin Yan Pei, Yun Dai, Mandy Garnett, Li Wang, Steven Grant, Daniella M. Schwartz, Jennifer Myers, Florence Su, Shuang Chen, Robert Z. Orlowski

Publikováno v: Cancer Research. 72:4225-4237

BH3 mimetic drugs induce cell death by antagonizing the activity of antiapoptotic Bcl-2 family proteins. Cyclin-dependent kinase (CDK) inhibitors that function as transcriptional repressors downregulate the Bcl-2 family member Mcl-1 and increase the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1baeb2c0747252c521a206864e666d5a
https://doi.org/10.1158/0008-5472.can-12-1118

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání