Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Mandy G Katz-Jaffe"'
Autor:
Michelle M Denomme, Jason C Parks, Blair R McCallie, Nathan I McCubbin, William B Schoolcraft, Mandy G Katz-Jaffe
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229904 (2020)
The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction
Externí odkaz:
https://doaj.org/article/a1477e38a2ec4f6b94cee179f4435a45
Autor:
Blair R McCallie, Jason C Parks, Alyssa L Patton, Darren K Griffin, William B Schoolcraft, Mandy G Katz-Jaffe
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159507 (2016)
DNA methylation is a key epigenetic mechanism responsible for gene regulation, chromatin remodeling, and genome stability, playing a fundamental role during embryonic development. The aim of this study was to determine if these epigenetic marks are a
Externí odkaz:
https://doaj.org/article/5dc619ac19e843a4ac456a16e160cc73
Autor:
Michelle M Denomme, Blair R McCallie, Jason C Parks, William B Schoolcraft, Mandy G Katz-Jaffe
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156980 (2016)
Epigenetic mechanisms such as DNA methylation regulate genomic imprinting and account for the distinct non-equivalence of the parental genomes in the embryo. Chromosomal aneuploidy, a major cause of infertility, distorts this highly regulated dispari
Externí odkaz:
https://doaj.org/article/3cbe2b76598a47b99220f53810d8f2ac
Autor:
Michelle M. Denomme, Blair R. McCallie, Mary E. Haywood, Jason C. Parks, William B. Schoolcraft, Mandy G. Katz-Jaffe
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Background Advanced paternal age (APA) is associated with adverse outcomes to offspring health, including increased risk for neurodevelopmental disorders. The aim of this study was to investigate the methylome and transcriptome of the first
Externí odkaz:
https://doaj.org/article/ab129e965f4a4f02bf55ec054ab6a50f
Publikováno v:
Reproductive BioMedicine Online. 44:858-865
What is the reproductive potential of embryos that achieve blastulation on day 7 followed by preimplantation genetic testing for aneuploidies (PGT-A) for infertility patients with slow embryo development?This was a retrospective cohort study in a pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e8afd6b3f1dd4c2e9f62f602b97a95
https://doi.org/10.1016/j.rbmo.2021.08.027
https://doi.org/10.1016/j.rbmo.2021.08.027
Autor:
Mandy G. Katz-Jaffe, Sydney L. Lane, Jason C. Parks, Blair R. McCallie, Rachel Makloski, William B. Schoolcraft
Publikováno v:
Life, Vol 10, Iss 11, p 250 (2020)
Advanced maternal age (AMA) is associated with reduced fertility due in part to diminished ovarian follicle quantity, inferior oocyte quality, chromosome aneuploidy, and lower implantation rates. Ovarian aging is accompanied by increased oxidative st
Externí odkaz:
https://doaj.org/article/404e113f06cb4a65a84f0027d3f5d4dd
Autor:
William B. Schoolcraft, Mary E. Haywood, Michelle M. Denomme, Mandy G. Katz-Jaffe, Blair R. McCallie
Publikováno v:
Fertility and Sterility. 116:309-318
Objective To evaluate the epigenetic consequence of a prolonged disease state of infertility in euploid blastocysts. Design Methylome analysis as well as targeted imprinted methylation and expression analysis on individual human euploid blastocysts e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f29901417beb6314a5a19693b2c82c
https://doi.org/10.1016/j.fertnstert.2021.01.040
https://doi.org/10.1016/j.fertnstert.2021.01.040
Autor:
William B. Schoolcraft, Taylor Pini, Sydney L. Lane, Mandy G. Katz-Jaffe, Mary E. Haywood, Blair R. McCallie
Publikováno v:
F&S Science. 2:153-163
Objective To investigate how endogenously elevated DNA fragmentation alters the human sperm proteome, and whether this fragmentation contributes to genomic deletions. Design Research study. Setting Commercial fertility clinic. Patient(s) Men with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6f8fa939e399633cddd81758c362f2
https://doi.org/10.1016/j.xfss.2021.03.001
https://doi.org/10.1016/j.xfss.2021.03.001
Autor:
Rachel Makloski, Jason C. Parks, Michelle M Denomme, Darren K. Griffin, Mandy G. Katz-Jaffe, Mary E. Haywood, William B. Schoolcraft, Blair R. McCallie
Publikováno v:
J Assist Reprod Genet
PURPOSE: To investigate the biological networks associated with DOR in young women and the subsequent molecular impact on preimplantation embryos. METHODS: Whole peripheral blood was collected from patients: young women presenting with diminished ova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0c28a899ce0c4e09c679391e0bf5c3
https://doi.org/10.1007/s10815-021-02155-8
https://doi.org/10.1007/s10815-021-02155-8
Autor:
Jason C. Parks, Kirk C. Hansen, Monika Dzieciatkowska, William B. Schoolcraft, Mandy G. Katz-Jaffe, J Russ, Taylor Pini
Publikováno v:
J Assist Reprod Genet
PURPOSE: In men, obesity may lead to poor semen parameters and reduced fertility. However, the causative links between obesity and male infertility are not totally clear, particularly on a molecular level. As such, we investigated how obesity modifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e5adbcfa4d0ddd4e92d18e7aaee42a
https://doi.org/10.1007/s10815-020-01707-8
https://doi.org/10.1007/s10815-020-01707-8