Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mandy Cromwell"'
Autor:
Adelfa E. Serrano, Jeffrey D. Dvorin, Emily R. Derbyshire, Clary B. Clish, Ralph Mazitschek, Carolyn K. Dong, Jon Clardy, Robert H. Barker, Jose F. Garcia-Bustos, Manoj T. Duraisingh, Vishal Patel, Maria Jose Lafuente, Leila S. Ross, Joseph F. Cortese, Bradley I. Coleman, Sameer Urgaonkar, Mandy Cromwell, Francisco-Javier Gamo, Dyann F. Wirth
Publikováno v:
Chemistry & Biology. 18(12):1602-1610
SummaryHere we report the discovery of tetracyclic benzothiazepines (BTZs) as highly potent and selective antimalarials along with the identification of the Plasmodium falciparum cytochrome bc1 complex as the primary functional target of this novel c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781ccfc6a4bade67f88cb5588a0f8690
Autor:
Ralph Mazitschek, Mandy Cromwell, Adelfa E. Serrano, Robert H. Barker, Dyann F. Wirth, Joseph F. Cortese, Jon Clardy, Sameer Urgaonkar
Publikováno v:
Org Lett
[Image: see text] The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27d5b014078d1049c7b42e5c9fb7815
https://doi.org/10.1021/ol101566h
https://doi.org/10.1021/ol101566h
Autor:
Christopher M. Treleaven, James Dodge, S. Pablo Sardi, Lamya S. Shihabuddin, Seng H. Cheng, Joshua Pacheco, Wei-Lien Chuang, Channa Bao, Richard L. Sidman, Samantha Cooper, Marissa Abraham, Mandy Cromwell
Recent genetic evidence suggests that aberrant glycosphingolipid metabolism plays an important role in several neuromuscular diseases including hereditary spastic paraplegia, hereditary sensory neuropathy type 1, and non-5q spinal muscular atrophy. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c464ef2f5054108bce69eea643407dc5
https://europepmc.org/articles/PMC4491749/
https://europepmc.org/articles/PMC4491749/
Autor:
Christopher M. Treleaven, Catherine Viel, Hyejung Park, Mandy Cromwell, James Dodge, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin, John P. Leonard, John Marshall, Jennifer Clarke, Bing Wang
Publikováno v:
Molecular Genetics and Metabolism. 117:S102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc00c3e3efe611cca771524e4272353
https://doi.org/10.1016/j.ymgme.2015.12.427
https://doi.org/10.1016/j.ymgme.2015.12.427
Autor:
John P. Leonard, Scott D. Bercury, Matthew DeRiso, Ronald K. Scheule, Mandy Cromwell, Diane Copeland, Seng H. Cheng, Mario A. Cabrera-Salazar, John Lydon, Nilesh Pande, Lingyun Li, William Weber
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43310 (2012)
PLoS ONE
PLoS ONE
Neuropathic Gaucher disease (nGD), also known as type 2 or type 3 Gaucher disease, is caused by a deficiency of the enzyme glucocerebrosidase (GC). This deficiency impairs the degradation of glucosylceramide (GluCer) and glucosylsphingosine (GluSph),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bf8054956df5589c662d09e1803e97
http://europepmc.org/articles/PMC3422338?pdf=render
http://europepmc.org/articles/PMC3422338?pdf=render
Autor:
Jose E. Guerrero-Bravo, Santiago Ferrer, Thomas O'Shea, Chris J. Janse, Noemi Magan, Keila N. Crespo-Llado, María Belén Jiménez-Díaz, Shahid M. Khan, Robert H. Barker, Jeffrey D. Klinger, Erin Tyndall, Ralph Mazitschek, Dyann F. Wirth, Amar Bir Singh Sidhu, Bradley I. Coleman, Vanesa Gomez, Jon Clardy, Manoj T. Duraisingh, Edmund Sybertz, Roger C. Wiegand, Cassandra Celatka, Iñigo Angulo-Barturen, Mark Bree, Sameer Urgaonkar, Mikaela Levine, Hanlan Liu, Mandy Cromwell, Adelfa E. Serrano, Ian Bathurst, Petros Papastogiannidis, Edward R. Lee, María Santos Martínez, Benito Munoz, Sergio Wittlin, Jing-wen Lin, Joseph F. Cortese, Renato Skerlj
Publikováno v:
Antimicrobial Agents and Chemotherapy, 55(6), 2612-2622
This study characterizes aminoindole molecules that are analogs of Genz-644442. Genz-644442 was identified as a hit in a screen of ∼70,000 compounds in the Broad Institute's small-molecule library and the ICCB-L compound collection at Harvard Medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fbde66a506d81a8bd5720aa4a9d64d
https://doi.org/10.1128/aac.01714-10
https://doi.org/10.1128/aac.01714-10
Autor:
Dyann F. Wirth, Joseph F. Cortese, Robert H. Barker, Mandy Cromwell, Jon Clardy, Sameer Urgaonkar, Adelfa E. Serrano, Ralph Mazitschek
Publikováno v:
ChemInform. 42
The target compounds are prepared from isatins in two steps by using tert-butyldimethylsilyl amine as an ammonia equivalent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::912e420743a84db77e33aadc8fc3f968
https://doi.org/10.1002/chin.201103112
https://doi.org/10.1002/chin.201103112