Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mandy Lawson"'
Autor:
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROT
Externí odkaz:
https://doaj.org/article/ec006f9560824ea494be6041bb1eeb60
Autor:
Larissa Carnevalli, Susana Ros, Jelena Urosevic, Natalie Cureton, Sophie Darcy, Mandy Lawson, Stuart Williamson, Pablo Morentin Gutierrez, Azadeh Bashi, Jennifer Moss, Christopher Morrow, Barry Simon, Teresa Klinowska
Publikováno v:
Cancer Research. 83:PD10-04
Next-generation oral selective estrogen receptor degraders (ngSERDs) are aiming to become the backbone endocrine therapy (ET) for patients with estrogen receptor positive (ER+) breast cancer (BC) by achieving greater ER signaling blockade than curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8282daf36c5d38b3097f50ee2a0db98
https://doi.org/10.1158/1538-7445.sabcs22-pd10-04
https://doi.org/10.1158/1538-7445.sabcs22-pd10-04
Autor:
James S. Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J. Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R. J. Davey, David I. Fisher, Eric T. Gangl, Tyler Grebe, Ryan D. Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J. Hughes, Thomas A. Hunt, Tony Johnson, Stefan L. Kavanagh, Teresa C. M. Klinowska, Carrie J. B. Larner, Mandy Lawson, Andrew S. Lister, David Longmire, Stacey Marden, Thomas M. McGuire, Caroline McMillan, Lindsay McMurray, Christopher J. Morrow, J. Willem M. Nissink, Thomas A. Moss, Daniel H. O’Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J. Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Publikováno v:
Journal of Medicinal Chemistry. 66:2918-2945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ec7d4c4fb73ee3f4aed9c21a77b1bf
https://doi.org/10.1021/acs.jmedchem.2c01964
https://doi.org/10.1021/acs.jmedchem.2c01964
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
Supplementary Figure S1. Vistusertib (AZD2014) causes a decrease in RB phosphorylation in the absence of cell cycle arrest. Supplementary Figure S2. Different mTOR inhibitors in combination with palbociclib cause a decrease in cell viability. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2971446864fbedb32439af08aab612
https://doi.org/10.1158/1535-7163.22510243
https://doi.org/10.1158/1535-7163.22510243
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
The cyclin dependent kinase (CDK)–retinoblastoma (RB)–E2F pathway plays a critical role in the control of cell cycle in estrogen receptor–positive (ER+) breast cancer. Small-molecule inhibitors of CDK4/6 have shown promise in this tumor type in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a430fac5fb19944258d4dc125065e6b
https://doi.org/10.1158/1535-7163.c.6539551.v1
https://doi.org/10.1158/1535-7163.c.6539551.v1
Autor:
Simon T. Barry, Stephen Green, Marie Cumberbatch, Emily Foster, Elizabeth A. Harrington, Barry R. Davies, Mandy Lawson, Steve Powell, Lara Ward, Stephen R. Wedge, Lillian Castriotta, Celina D'Cruz, Donald Ogilvie, Paul D. Smith, Martina Fitzek, Bernard Barlaam, Claire Crafter, Hannah Dry, Rebecca Ellston, Carol Lenaghan, Cath Trigwell, Lyndsey Hanson, Sabina Cosulich, Urs Hancox
Supplementary Materials text. Supplementary text to support supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc9bdcf5800ec6832230c58fa50deb2
https://doi.org/10.1158/1535-7163.22502410.v1
https://doi.org/10.1158/1535-7163.22502410.v1
Autor:
Sarat Chandarlapaty, José Baselga, Geoffrey Greene, John A. Katzenellenbogen, Sean Fanning, Zhiqiang Li, Sharmeen Uddin, Teresa S. Martin, Kathryn E. Carlson, Elisa De Stanchina, Wai Lin Wong, Christopher Morrow, Joanne Wilson, Aaron Smith, Anne Marie Mazzola, Anne U. Goeppert, Mandy Lawson, Pedram Razavi, Hazel Weir, Weiyi Toy
Supplementary Figures 1 - 8, Tables 1 - 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dff68a706294f698444df25bf64477e
https://doi.org/10.1158/2159-8290.22531658
https://doi.org/10.1158/2159-8290.22531658
Autor:
Simon T. Barry, Stephen Green, Marie Cumberbatch, Emily Foster, Elizabeth A. Harrington, Barry R. Davies, Mandy Lawson, Steve Powell, Lara Ward, Stephen R. Wedge, Lillian Castriotta, Celina D'Cruz, Donald Ogilvie, Paul D. Smith, Martina Fitzek, Bernard Barlaam, Claire Crafter, Hannah Dry, Rebecca Ellston, Carol Lenaghan, Cath Trigwell, Lyndsey Hanson, Sabina Cosulich, Urs Hancox
Supplementary Tables 1-3 and Figure 1-7. Supp Table 1 Summary of cell line origins and verification. Supp Table 2 Summary of antibodies used in all experimental analysis Supp Fig 1 AZD8186 inhibits PI3K pathway in PTEN null but not PTEN WT PIKC3A MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1480195d4ae54dd467c3ee5679efbedf
https://doi.org/10.1158/1535-7163.22502407.v1
https://doi.org/10.1158/1535-7163.22502407.v1
Autor:
Sarat Chandarlapaty, José Baselga, Geoffrey Greene, John A. Katzenellenbogen, Sean Fanning, Zhiqiang Li, Sharmeen Uddin, Teresa S. Martin, Kathryn E. Carlson, Elisa De Stanchina, Wai Lin Wong, Christopher Morrow, Joanne Wilson, Aaron Smith, Anne Marie Mazzola, Anne U. Goeppert, Mandy Lawson, Pedram Razavi, Hazel Weir, Weiyi Toy
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f9ecf550815949a98ad6508793ed05
https://doi.org/10.1158/2159-8290.22531655
https://doi.org/10.1158/2159-8290.22531655
Autor:
Chris De Savi, Celina D'Cruz, Anne Marie Mazzola, Ermira Pazolli, Brendon Ladd, Graham Richmond, Claire Sadler, Steve Powell, Rachel Rowlinson, Zena Wilson, Graeme E. Walker, Gareth Davies, Michael Tonge, Stuart E. Pearson, Richard A. Norman, Thomas Moss, Philip MacFaul, Galith Karoutchi, Lyman J.L. Feron, Craig S. Donald, Michael Hulse, Peter Ballard, Camila de Almeida, Jon O. Curwen, Rowena J. Callis, David Buttar, Alfred A. Rabow, Mandy Lawson, Robert H. Bradbury, Hazel M. Weir
Legends for Supplementary Figures 1 - 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2ea8b1988f522a97b4476bc1bfb489
https://doi.org/10.1158/0008-5472.22409537.v1
https://doi.org/10.1158/0008-5472.22409537.v1