Výsledky vyhledávání - "Mandy, Donaldson"

Combination of Peptide YY3–36with GLP-17–36 amideCauses an Increase in First-Phase Insulin Secretion after IV Glucose

Autor: Ian F. Godsland, Ali Alsafi, Rachel C. Troke, Victoria Salem, Mandy Donaldson, Mohammad A. Ghatei, Kevin C.R. Baynes, James Minnion, Benjamin C. T. Field, Stephen R. Bloom, Tricia Tan, Akila De Silva, Shivani Misra

Publikováno v: E2324
E2317
The Journal of Clinical Endocrinology and Metabolism

Context: The combination of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) has been proposed as a potential treatment for diabetes and obesity. However, the combined effects of these hormones, PYY3–36 and GLP-17–36 amide, on glucose homeost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe56a1fdcfc9ad8d07f1dc825216219a
https://doi.org/10.1210/jc.2014-2143

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Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception

Autor: Laura Owen, Luna Samanta, Olayiwola Oduwole, Ilpo Huhtaniemi, Nicholas E. M. Wood, Brian G. Keevil, Natalia Vydra, Mandy Donaldson, Kikkeri N. Naresh

Publikováno v: The FASEB Journal

Testosterone (T), alone or in combina- tion with progestin, provides a promising approach to hormonal male contraception. Its principle relies on enhanced negative feedback of exogenous T to sup- press gonadotropins, thereby blocking the testicular T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c500dcc158b87d7e2778e903b1c85fa3
http://europepmc.org/articles/PMC4376501

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Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism

Autor: Ben Jones, Jaimini Cegla, Niamh M. Martin, Richard Chapman, Anthony P. Goldstone, Deborah Papadoulou, Lata Seyani, Karim Meeran, Mandy Donaldson, Katie Wynne, Tricia Tan

Publikováno v: Clinical Endocrinology. 78:738-742

SummaryObjective The insulin tolerance test (ITT) is contraindicated in a proportion of patients with suspected ACTH deficiency. The aim of this study was to investigate the diagnostic accuracy of the glucagon stress test (GST) compared with the over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209fef34fca94eb608852270f2592b47
https://doi.org/10.1111/cen.12043

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Associations of serum 25-hydroxyvitamin D with circulating PTH, phosphate and calcium in patients with primary hyperparathyroidism

Autor: Karim Meeran, Mandy Donaldson, Manish Modi, Waljit S. Dhillo, Fausto Palazzo, Channa N. Jayasena, Akila De Silva

Publikováno v: Clinical Endocrinology. 78:838-843

Background Despite NIH clinical recommendations, many clinicians are reluctant to replace vitamin D in patients with hypercalcaemia with primary hyperparathyroidism (PHP) due to concerns over aggravating hypercalcaemia. Furthermore, the optimum level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7eef657cad337a323ec602b9b6e9fb
https://doi.org/10.1111/cen.12062

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The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly

Autor: Alexander N Comninos, Waljit S. Dhillo, Holly Clarke, Channa N. Jayasena, Karim Meeran, Mandy Donaldson

Publikováno v: Clinical Endocrinology. 75:220-225

Background Acromegaly is characterized by the hypersecretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). This leads to an increased cardiovascular, cerebrovascular and metabolic morbidity resulting in excess mortality. There is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf9fefe0cac6b90c84f53a6e11cf66c7
https://doi.org/10.1111/j.1365-2265.2011.04019.x

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Utility of the urine calcium-to-creatinine ratio to diagnose primary hyperparathyroidism in asymptomatic hypercalcaemic patients with vitamin D deficiency

Autor: Channa N. Jayasena, Mohammad Mahmud, Fausto Palazzo, Mandy Donaldson, Karim Meeran, Waljit S. Dhillo

Publikováno v: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 48:126-129

Background Primary hyperparathyroidism (PHP) is the most common cause of hypercalcaemia, and often requires surgical treatment. Familial hypocalciuric hypercalcaemia (FHH) has similar biochemical features to PHP, but requires no treatment. The most c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e97150e41d818a6a209952820fa661
https://doi.org/10.1258/acb.2010.010202

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Dexamethasone-Suppressed Corticotrophin-Releasing Hormone–Stimulation Test Does Not Reliably Diagnose or Predict Recurrence of Cushing Disease

Autor: Niamh M. Martin, Waljit S. Dhillo, Karim Meeran, Mandy Donaldson, Victoria Salem

Publikováno v: Clinical Chemistry. 56:1031-1034

First-line treatment for Cushing disease is surgical removal of the adrenocorticotrophin-secreting pituitary tumor. Because of the high risk of relapse, it is essential that patients receive long-term postoperative follow-up for disease recurrence th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1a8cd7e3eaa0d1930935810d7f5908
https://doi.org/10.1373/clinchem.2010.143263

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The Relationship Between Androgens and Arterial Stiffness in Older Men

Autor: Mandy Donaldson, F. Dockery, Christopher J. Bulpitt, Sarojani Fernandez, Chakravarthi Rajkumar

Publikováno v: Journal of the American Geriatrics Society. 51:1627-1632

Objectives: To assess the relationship between endogenous androgen levels and arterial stiffness in older men. Design: A retrospective, cross-sectional study. Setting: A London hospital-based, clinical research unit for the elderly. Participants: Fif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::538ba5da75cd211a30233ab25f906dcd
https://doi.org/10.1046/j.1532-5415.2003.51515.x

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Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia

Autor: Sanjiv Agarwal, Chakravarthi Rajkumar, F. Dockery, Christopher J. Bulpitt, Mandy Donaldson

Publikováno v: Clinical Science. 104:195-201

The role of androgens in cardiovascular disease is uncertain. We aimed to determine the vascular effects of androgen suppression in men with prostate cancer. Arterial stiffness (or 'compliance') was measured in 16 men (71+/-9 years, mean+/-S.D.) prio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849958c533ca5833a8ebcc9938d9990b
https://doi.org/10.1042/cs1040195

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Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF

Autor: Sappho Michael, Robert Winston, A. Ravhon, Geoff Trew, Mandy Donaldson, Stuart Lavery, Raul Margara

Publikováno v: Human Reproduction. 15:2297-2301

The study was designed to examine whether dynamic measurements of inhibin B and oestradiol following single administration of buserelin acetate were correlated with the ovarian response to stimulation in IVF. A total of 37 patients undergoing IVF tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8c1a174a9c60e75dab1d3006f8feae
https://doi.org/10.1093/humrep/15.11.2297

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