Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mandvi Bharadwaj"'
Autor:
Patricia T. Illing, Andy van Hateren, Rachel Darley, Nathan P. Croft, Nicole A. Mifsud, Samuel King, Lyudmila Kostenko, Mandvi Bharadwaj, James McCluskey, Tim Elliott, Anthony W. Purcell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the
Externí odkaz:
https://doaj.org/article/aa6e9a64a82f4a819e31c997dcdb4c3e
Autor:
Emma J. Grant, Tracy M. Josephs, Liyen Loh, E. Bridie Clemens, Sneha Sant, Mandvi Bharadwaj, Weisan Chen, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact an
Externí odkaz:
https://doaj.org/article/e3208577560a455ba744a1baab24971d
Autor:
Rachel Sacks-Davis, Campbell K Aitken, Peter Higgs, Tim Spelman, Alisa E Pedrana, Scott Bowden, Mandvi Bharadwaj, Usha K Nivarthi, Vijayaprakash Suppiah, Jacob George, Jason Grebely, Heidi E Drummer, Margaret Hellard
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80216 (2013)
UnlabelledHepatitis C virus reinfection and spontaneous clearance of reinfection were examined in a highly characterised cohort of 188 people who inject drugs over a five-year period. Nine confirmed reinfections and 17 possible reinfections were iden
Externí odkaz:
https://doaj.org/article/69d3f6c371274168910dd797fe18d11d
Publikováno v:
BioTechniques, Vol 30, Iss 1, Pp 36-38 (2001)
Externí odkaz:
https://doaj.org/article/6c66d80a129041048831869b877ee30f
Autor:
Nicole A. Mifsud, Rachel Darley, James McCluskey, Tim Elliott, Anthony W. Purcell, Samuel King, Patricia T. Illing, Mandvi Bharadwaj, Nathan P. Croft, Lyudmila Kostenko, Andy van Hateren
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f28c81e86b89bcb2bc4ba51457f636a
https://doi.org/10.3389/fimmu.2021.672737
https://doi.org/10.3389/fimmu.2021.672737
Autor:
Weisan Chen, E.B. Clemens, Emma J. Grant, Katherine Kedzierska, Stephanie Gras, Mandvi Bharadwaj, Tracy M. Josephs, Jamie Rossjohn, Liyen Loh, Sneha Sant
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of the virus due to minimal antibody-mediated immunity. In that case, established CD8+ T-cells can reduce disease severity. However, as mutations occur sp
Publikováno v:
Personalized medicine. 7(5)
Multiple genetic and nongenetic factors can modify the action of a drug, resulting in varied responses to a particular drug across different individuals. Personalized medicine incorporates the comprehensive knowledge of these factors to facilitate th
Autor:
Samantha Lilly Tracy, Mandvi Bharadwaj, Richard Berry, Isabelle S Lucet, Margaret Hellard, D. S. Bowden, Lars Kjer-Nielsen, Jamie Rossjohn, Stephanie Gras, Usha K Nivarthi, Anthony W. Purcell, John J. Miles, James McCluskey
Publikováno v:
The Journal of Immunology. 193:5402-5413
Mutations in T cell epitopes are implicated in hepatitis C virus (HCV) persistence and can impinge on vaccine development. We recently demonstrated a narrow bias in the human TCR repertoire targeted at an immunodominant, but highly mutable, HLA-B*080
Autor:
Mandvi Bharadwaj, Jamie Rossjohn, Margaret Hellard, Tracy M. Josephs, Katherine Kedzierska, Linda Wooldridge, Stephanie Gras, Emma J. Grant, Sophie A. Valkenburg
Publikováno v:
Grant, E J, Josephs, T M, Valkenburg, S A, Wooldridge, L, Hellard, M, Rossjohn, J, Bharadwaj, M, Kedzierska, K & Gras, S 2016, ' Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures ', Journal of Biological Chemistry, vol. 291, no. 47, pp. 24335-24351 . https://doi.org/10.1074/jbc.M116.753988
αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. To provide efficient protective anti-viral immunity, a single TCR ideally needs to cross-react with a multitude of pathogenic epitopes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a66e51aa3df69727739162778e10bcb
https://hdl.handle.net/1983/99f17352-5c12-4c35-846c-b6d8bb8201e1
https://hdl.handle.net/1983/99f17352-5c12-4c35-846c-b6d8bb8201e1
Autor:
V. Suppiah, Jacob Nattermann, Elizabeth E. Powell, Antonina Smedile, M. Michalk, Mandvi Bharadwaj, Sherie Smith, Shona Fletcher, Martin Weltman, Julie R. Jonsson, Elizabeth Snape, David Sheridan, Gregory J. Dore, Patrick McClure, Richard Norris, Helen Barrie, M.L. Abate, David R. Booth, Dianne How-Chow, Thomas Berg, Jacob George, Jason Grebely, G. J. Stewart, Stephen M. Riordan, Margaret Bassendine, Sacha Stelzer-Braid, Golo Ahlenstiel, William L. Irving, Ulrich Spengler, Tobias Mueller, Nicola J. Armstrong, Vincenzo Fragomeli, Barbara Malik, Kate S. O'Connor, Tanya L. Applegate, Gail V. Matthews
Publikováno v:
BASE-Bielefeld Academic Search Engine
IL28B polymorphisms strongly predict spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. A recent study proposed a 32-base pair deletion in the CC-chemokine receptor 5 (CCR5) gene (CCR5-D32) interacting with the IL28B po