Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Mandi M. Murph"'
Autor:
Mandi M. Murph
Publikováno v:
Cancers, Vol 11, Iss 9, p 1369 (2019)
The revelation that microRNAs (miRNAs) exist within the human genome uncovered an underappreciated mechanism of gene expression. For cells to regulate expression of their genes, miRNA molecules and argonaute proteins bind to mRNAs and interfere with
Externí odkaz:
https://doaj.org/article/9a0a442997c543b1b41b1f4fe5ea6b1e
Publikováno v:
Cancers, Vol 3, Iss 1, Pp 1232-1252 (2011)
Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment ef
Externí odkaz:
https://doaj.org/article/c448802e305341a2a712bd9e6de63a1f
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/7aed9bbfbced4dc8a0094aa7441e004f
Autor:
Molly K. Altman, Duy T. Nguyen, Santosh B. Patel, Jada M. Fambrough, Aaron M. Beedle, William J. Hardman, Mandi M. Murph
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
The regulator of G-protein signaling 5 (RGS5) belongs to a family of GTPase activators that terminate signaling cascades initiated by extracellular mediators and G-protein-coupled receptors. RGS5 has an interesting dual biological role. One functiona
Externí odkaz:
https://doaj.org/article/d24ae6c5e231406faad28ac26d41a8d8
Supplementary Figure 5. miR-122-5p abundance fluctuates in heart tissue, resultant from LPAR3 expression. Tissues were collected from knock-out mice lacking the first exon of the LPAR3 and their wild-type siblings and assessed for miR-122-5p and LPAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d280cb1698094b08319c3b34e89ec02
https://doi.org/10.1158/1541-7786.22515406
https://doi.org/10.1158/1541-7786.22515406
Supplementary Figure 2. Messenger RNA expression differences between cell types. Other mRNAs were assessed to compare relative LPAR3 expression as well as CCNG1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfbd108880d488464eea60a823e6790
https://doi.org/10.1158/1541-7786.22515421
https://doi.org/10.1158/1541-7786.22515421
The lysophosphatidic acid receptor-3 (LPAR3) is a G protein–coupled receptor that mediates viability among malignant cells and aggressiveness among certain tumors. The study's objective was to determine the interplay between LPAR3 and miRNAs to imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401b0680c5513cb45b867cc8a732d6d6
https://doi.org/10.1158/1541-7786.c.6541081
https://doi.org/10.1158/1541-7786.c.6541081
Supplementary Figure 3. Microfluidics visualization of nanoparticles from LPAR3. The movies illustrate the difference between the smaller/almost indiscernible white dots, which are exosome nanoparticles, secreted by cells expressing LPAR3-wt versus t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e95b3abb546c1f361606d3ab15305c
https://doi.org/10.1158/1541-7786.22515415
https://doi.org/10.1158/1541-7786.22515415
Supplementary Figure 4. Comparison of exogenously-added reagents. The qRT-PCR results display the relative abundance of miR-122-5p with no treatment (untreated) versus DharmaFECT alone, miR-122-5p mimic and miR-122-5p antagomir. The latter shows an u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31aa00376f79de8c97f9ee69ba363a47
https://doi.org/10.1158/1541-7786.22515409.v1
https://doi.org/10.1158/1541-7786.22515409.v1