A Novel Cytotoxic Mechanism for Triple-Negative Breast Cancer Cells Induced by the Type II Heat-Labile Enterotoxin LT-IIc through Ganglioside Ligation.

Autor: King-Lyons ND; Department of Microbiology and Immunology, The Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA., Bhati AS; Department of Microbiology and Immunology, The Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA., Hu JC; The Witebsky Center for Microbiology and Immunology, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.; Department of Medicine, Division of Infectious Disease, The Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.; VA Western New York Healthcare System, Buffalo, NY 14215, USA., Mandell LM; Department of Microbiology and Immunology, The Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA., Shenoy GN; Department of Microbiology and Immunology, The Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.; The Witebsky Center for Microbiology and Immunology, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA., Willison HJ; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Connell TD; Department of Microbiology and Immunology, The Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.; The Witebsky Center for Microbiology and Immunology, The University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.

Publikováno v: Toxins [Toxins (Basel)] 2024 Jul 11; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 11.

LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity.

Autor: Greene CJ; The Witebsky Center for Microbial Pathogenesis and Immunology, The University at Buffalo, Buffalo, New York, United States of America., Chadwick CM, Mandell LM, Hu JC, O'Hara JM, Brey RN 3rd, Mantis NJ, Connell TD

Publikováno v: PloS one [PLoS One] 2013 Aug 02; Vol. 8 (8), pp. e69678. Date of Electronic Publication: 2013 Aug 02 (Print Publication: 2013).

LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb.

Autor: Nawar HF; The Witebsky Center for Microbial Pathogenesis and Immunology, Department of Microbiology & Immunology, The University at Buffalo, The State University of New York at Buffalo, Buffalo, NY 14214, USA., Greene CJ, Lee CH, Mandell LM, Hajishengallis G, Connell TD

Publikováno v: Vaccine [Vaccine] 2011 Jan 17; Vol. 29 (4), pp. 721-7. Date of Electronic Publication: 2010 Nov 21.