Výsledky vyhledávání - "Mandeep Pinky Gaidhu"

Chronic AICAR-induced AMP-kinase activation regulates adipocyte lipolysis in a time-dependent and fat depot-specific manner in rats

Autor: Rolando B. Ceddia, Mandeep Pinky Gaidhu, George Bikopoulos

Publikováno v: American Journal of Physiology-Cell Physiology. 303:C1192-C1197

This study investigated the effects of chronic in vivo AMP-kinase activation with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) on lipolysis in subcutaneous inguinal, epididymal, and retroperitoneal fat pads. Male Wistar rats received

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ba40b851123d5f2feb94dbfe657ca0
https://doi.org/10.1152/ajpcell.00159.2012

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The Role of Adenosine Monophosphate Kinase in Remodeling White Adipose Tissue Metabolism

Autor: Mandeep Pinky Gaidhu, Rolando B. Ceddia

Publikováno v: Exercise and Sport Sciences Reviews. 39:102-108

Recent evidence indicates that the enzyme adenosine monophosphate (AMP) kinase exerts important fat-reducing effects in the adipose tissue, which has created great interest in this enzyme as a potential target for obesity treatment. This review summa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf228424b9bae9ce3c8d44a88e7cebd
https://doi.org/10.1097/jes.0b013e31820ac03e

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Disruption of AMPKα1 Signaling Prevents AICAR-Induced Inhibition of AS160/TBC1D4 Phosphorylation and Glucose Uptake in Primary Rat Adipocytes

Autor: Mandeep Pinky Gaidhu, Fawad Noor, Rolando B. Ceddia, Robert L. S. Perry

Publikováno v: Molecular Endocrinology. 24:1434-1440

The aim of this study was to investigate the molecular mechanisms by which AMP-kinase (AMPK) activation inhibits basal and insulin-stimulated glucose uptake in primary adipocytes. Rat epididymal adipocytes were exposed to 5-aminoimidazole-4-carboxami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed384bc87f52d602f0a963eff3310a0
https://doi.org/10.1210/me.2009-0502

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Remodeling glucose and lipid metabolism through AMPK activation: relevance for treating obesity and Type 2 diabetes

Autor: Rolando B. Ceddia, Mandeep Pinky Gaidhu

Publikováno v: Clinical Lipidology. 4:465-477

In recent years, AMP-activated protein kinase (AMPK) has emerged as a potential target for physiological and pharmacologic treatment of several metabolic disorders. AMPK is a heterotrimeric enzyme that has been proposed to function as a ‘fuel gauge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b90f9a862887eda3a478b4dc757a75dd
https://doi.org/10.2217/clp.09.30

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Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR-induced AMPK Activation

Autor: Rolando B. Ceddia, Mandeep Pinky Gaidhu, Nicole M. Anthony

Publikováno v: Obesity. 17:1312-1317

This study investigated the role of adenosine monophosphate-activated protein kinase (AMPK) in the regulation of lipolysis in visceral (VC) and subcutaneous (SC) rat adipocytes and the molecular mechanisms involved in this process. VC (epididymal and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eed27cbc0fda52071e14e1bec81fc6a
https://doi.org/10.1038/oby.2008.645

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Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells

Autor: S. Habib, Mandy So, Michael U. Musheev, M. Mirpourian, Rolando B. Ceddia, Aurelio da Silva Pimenta, Sergiu Fediuc, Rui Curi, Mandeep Pinky Gaidhu

Publikováno v: Journal of Cellular Physiology. 217:478-485

The aim of this study was to investigate the chronic effects of palmitate on fatty acid (FA) oxidation, AMPK/ACC phosphorylation/activation, intracellular lipid accumulation, and the molecular mechanisms involved in these processes in skeletal muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1fc03e4ff5d19ede6904195387cbc3
https://doi.org/10.1002/jcp.21520

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Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity

Autor: Andrea Frontini, Saverio Cinti, Steven Hung, Kathryn E. Pistor, Mandeep Pinky Gaidhu, Rolando B. Ceddia

Publikováno v: Journal of Lipid Research, Vol 52, Iss 9, Pp 1702-1711 (2011)

This study investigated the effect of chronic AMP-kinase (AMPK) activation with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) on white adipose tissue (WAT) metabolism and the implications for visceral (VC) and subcutaneous (SC) adiposi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5b51a061ef7a6f02dc792a730e331e
https://pubmed.ncbi.nlm.nih.gov/21737753

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Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK

Autor: Mandeep Pinky Gaidhu, Thomas J. Hawke, Rolando B. Ceddia, Prital Patel, Nicole M. Anthony

Publikováno v: American journal of physiology. Cell physiology. 298(4)

This study investigated the molecular mechanisms by which a high-fat diet (HFD) dysregulates lipolysis and lipid metabolism in mouse epididymal (visceral, VC) and inguinal (subcutaneous, SC) adipocytes. Eight-weeks of HFD feeding increased adipose tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b322f58a717cd63d9baefd9ec223bfe
https://pubmed.ncbi.nlm.nih.gov/20107043

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