Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Mandar V. Kulkarni"'
1
Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LC–MS/MS
Autor: Alexandra N Tichy, David R. Peaper, Mandar V. Kulkarni, Michael E. Hodsdon, Michael Jarvis, Thomas S. Murray
Publikováno v: Bioanalysis. 5:147-157
Background: Bacteria are increasingly resistant to antibiotics used to treat life-threatening infections in critically ill patients. The carbapenems represent the last line of defense against Gram-negative rods that are increasingly resistant to all
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c62128df07941f55671f8f6efe42fe
https://doi.org/10.4155/bio.12.310
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2
Use of imipenem to detect KPC, NDM, OXA, IMP, and VIM carbapenemase activity from gram-negative rods in 75 minutes using liquid chromatography-tandem mass spectrometry
Autor: A. N. Zurita, J. S. Pyka, Mandar V. Kulkarni, David R. Peaper, T. S. Murray, Michael E. Hodsdon
Publikováno v: Journal of clinical microbiology. 52(7)
Resistance to extended-spectrum β-lactam antibiotics has led to a greater reliance upon carbapenems, but the expression of carbapenemases threatens to limit the utility of these drugs. Current methods to detect carbapenemase activity are suboptimal,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf94e3ddb7051aecb650ad7a81b9a0d4
https://pubmed.ncbi.nlm.nih.gov/24789180
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4
Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation
Autor: Naomi E. Chayen, David G. Myszka, Mandar V. Kulkarni, M. Cristina Tettamanzi, Camille Keeler, Michael E. Hodsdon, Elias Lolis, James W. Murphy
Publikováno v: The Journal of biological chemistry. 285(49)
Human prolactin (hPRL), a member of the family of hematopoietic cytokines, functions as both an endocrine hormone and autocrine/paracrine growth factor. We have previously demonstrated that recognition of the hPRL·receptor depends strongly on soluti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0457dd3620f3f9bebb1bb0c9e43d0775
https://pubmed.ncbi.nlm.nih.gov/20889499
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5
N-Myc is a downstream target of RET signaling and is required for transcriptional regulation of p18(Ink4c) by the transforming mutant RET(C634R)
Autor: David S. Franklin, Mandar V. Kulkarni
Publikováno v: Molecular oncology. 5(1)
Inherited activating mutations in RET predispose humans to Multiple Endocrine Neoplasia type-2 (MEN2). The MEN2A-specific mutation RETC634R, RET2A, has been shown to simultaneously downregulate the CDKIs p18 and p27, and upregulate cyclin D1. Importa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4bf636e0b90310eaa87812892e95d5
https://pubmed.ncbi.nlm.nih.gov/21112821
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6
Simultaneous downregulation of CDK inhibitors p18(Ink4c) and p27(Kip1) is required for MEN2A-RET-mediated mitogenesis
Autor: P P Joshi, B K Yu, Mandar V. Kulkarni, D L Norton, D S Franklin, Jwm Hoppener, K R Smith, W van Veelen
Publikováno v: Oncogene. 26(4)
Multiple endocrine neoplasia type 2A (MEN2A) is predisposed by mutations in the RET proto-oncogene. Low expression of the cyclin-dependent kinase inhibitor (CDKI) p27(Kip1) is present in thyroid tumors, and recent evidence demonstrates p27 downregula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8a61da6c0adff64e5e32f6f23c88f3
https://pubmed.ncbi.nlm.nih.gov/16953232
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Plný text Recenzováno Digitální knihovna AV ČR
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